1-Lauryl-2-pyrrolidone
- Product Name
- 1-Lauryl-2-pyrrolidone
- CAS No.
- 2687-96-9
- Chemical Name
- 1-Lauryl-2-pyrrolidone
- Synonyms
- 1-DODECYL-2-PYRROLIDINONE;LAURYL PYRROLIDONE;N-DODECYL-2-PYRROLIDONE;Creastar Au-Ex;Sulfadone LP-300;N-Laurylpyrrolidone;N-DODECYLPYRROLIDONE;1-dodecylpyrrolidone;1-Lauryl-2-pyrrolido;1-Lauryl-2-pyrrolidone
- CBNumber
- CB4358536
- Molecular Formula
- C16H31NO
- Formula Weight
- 253.42
- MOL File
- 2687-96-9.mol
1-Lauryl-2-pyrrolidone Property
- Melting point:
- 4°C
- Boiling point:
- 202-205 °C11 mm Hg(lit.)
- Density
- 0.89 g/mL at 25 °C(lit.)
- vapor pressure
- 0.002Pa at 25℃
- refractive index
- n20/D 1.466(lit.)
- Flash point:
- >230 °F
- storage temp.
- Sealed in dry,Room Temperature
- form
- viscous liquid
- pka
- -0.43±0.20(Predicted)
- Appearance
- Colorless to light yellow Liquid
- Water Solubility
- 51.7mg/L at 20℃
- InChIKey
- NJPQAIBZIHNJDO-UHFFFAOYSA-N
- LogP
- 4.03 at 21℃
- CAS DataBase Reference
- 2687-96-9(CAS DataBase Reference)
- EPA Substance Registry System
- N-Lauryl-2-pyrrolidone (2687-96-9)
Safety
- Hazard Codes
- C,N
- Risk Statements
- 34-43-50/53
- Safety Statements
- 26-36/37/39-45-60-61
- RIDADR
- UN 3267 8/PG 3
- WGK Germany
- 2
- RTECS
- UY5768000
- HazardClass
- 8
- PackingGroup
- III
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
H317May cause an allergic skin reaction
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P272Contaminated work clothing should not be allowed out of the workplace.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 335673
- Product name
- 1-Dodecyl-2-pyrrolidinone
- Purity
- 99%
- Packaging
- 250ml
- Price
- $79.54
- Updated
- 2025/07/31
- Product number
- D494573
- Product name
- 1-Dodecyl-2-pyrrolidinone
- Packaging
- 2mL
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 099851
- Product name
- 1-Dodecylpyrrolidin-2-one
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $167
- Updated
- 2021/12/16
- Product number
- 099851
- Product name
- 1-Dodecylpyrrolidin-2-one
- Purity
- 95+%
- Packaging
- 1g
- Price
- $370
- Updated
- 2021/12/16
- Product number
- 099851
- Product name
- 1-Dodecylpyrrolidin-2-one
- Purity
- 95+%
- Packaging
- 5g
- Price
- $1040
- Updated
- 2021/12/16
1-Lauryl-2-pyrrolidone Chemical Properties,Usage,Production
Chemical Properties
Colorless transparent liquid
Uses
1-Dodecyl-2-pyrrolidinone was used in the preparation of few-layered flakes of molybdenum disulfide (MoS2) via liquid phase exfoliation of bulk MoS2 powder.
Definition
ChEBI: 1-dodecylpyrrolidin-2-one is pyrrolidin-2-one substituted at nitrogen by an n-dodecyl group. It has a role as an epitope.
General Description
1-Dodecyl-2-pyrrolidinone is an N-alkyl lactam and its reduction with LiH3BNMe2 to the corresponding amine has been reported. It is a potential melatonin-specific chemical penetration enhancer.
Flammability and Explosibility
Non flammable
Synthesis
616-45-5
143-15-7
2687-96-9
Step A: Tetrabutylammonium bromide (950 mg, 3 mmol, 0.05 eq.) and powdered potassium hydroxide (23.1 g, 411 mmol, 7 eq.) were sequentially added to a toluene (60 mL) solution of 2-pyrrolidone (5.00 g, 58.8 mmol) under stirring conditions. Subsequently, a toluene solution of bromododecane (18.5 mL, 76.4 mmol, 1.3 eq.) was added to the mixture. The reaction mixture was heated to 50 °C and stirred at this temperature overnight. The progress of the reaction was monitored by thin layer chromatography (TLC) using a solvent mixture of ethyl acetate and cyclohexane (4:1, v/v) as the unfolding agent and phosphomolybdic acid as the color developer until the complete disappearance of 2-pyrrolidone. After completion of the reaction, the mixture was cooled to room temperature, 60 mL of water was added and stirring was continued for 15 min. The aqueous and organic phases were separated and the aqueous phase was extracted once with diethyl ether (60 mL). The organic phase was combined, dried with anhydrous sodium sulfate, filtered and concentrated. The product was purified by vacuum distillation (146 °C, 0.5 mbar) to afford N-dodecylpyrrolidin-2-one in 80% yield. The structure of the product was characterized by 1H NMR and 13C NMR: 1H NMR (400 MHz, CDCl3) δ (ppm): 0.88 (t, 3H, J = 7.0 Hz, CH3); 1.25-1.31 (m, 18H, CH2); 1.47-1.54 (m, 2H, Alk-CH2-CH2-N); 1.97- 2.05 (m, 2H, CO-CH2-CH2-CH2-N); 2.38 (t, 2H, J = 8.0 Hz, CO-CH2-CH2-CH2-N); 3.26 (t, 2H, J = 7.5 Hz, Alk-CH2-CH2-N); 3.37 (t, 2H, J = 7.0 Hz, CO-CH2-CH2-CH2- N).13C NMR (100 MHz, CDCl3) δ (ppm): 14.3 (CH3); 18.1 (CO-CH2-CH2-CH2-N); 22.9; 27.0 (CH2alk); 27.5 (Alk-CH2-CH2-N); 29.5; 29.7; 29.8; 29.9 (CH2alk); 31.3 (CO-CH2-CH2-CH2-N); 32.1 (CH2alk); 42.7 (Alk-CH2-CH2-N); 47.2 (CO-CH2-CH2-CH2-N); 174.9 (CO).
References
[1] Patent: US2015/133688, 2015, A1. Location in patent: Page/Page column
1-Lauryl-2-pyrrolidone Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-Lauryl-2-pyrrolidone manufacturers
- Product
- 1-Lauryl-2-pyrrolidone 2687-96-9
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100 mt
- Release date
- 2024-11-11
- Product
- 1-dodecyl-2-pyrrolidinone 2687-96-9
- Price
- US $0.00/kg
- Min. Order
- 20kg
- Purity
- 99%
- Supply Ability
- 20 tons
- Release date
- 2025-03-24
- Product
- Lauryl Pyrrolidone 2687-96-9
- Price
- US $8.70/KG
- Min. Order
- 10KG
- Purity
- 99.5% min
- Supply Ability
- 10000kg
- Release date
- 2024-08-21