Phentolamine hydrochloride

Product Name: Phentolamine hydrochloride
CAS No.: 73-05-2
Chemical Name: Phentolamine hydrochloride
Synonyms: c-7337;phentolaminechloride;Regitine hydrochloride;PHENTOLAMINE HYDROCHLORIDE;Phentolamine Hydrochloride (300 mg);Phentolamine hydrochloride USP/EP/BP;Phentolamine Hydrochloride (1529005);Phentolamine hydrochloride, Non-selective alpha antagonist;2-[N-(M-HYDROXYPHENYL)-P-TOLUIDINOMETHYL]IMIDAZOLINE HYDROCHLORIDE;m-(n-(2-imidazolin-2-ylmethyl)-p-toluidino)-phenomonohydrochloride
CBNumber: CB4358864
Molecular Formula: C17H20ClN3O
Formula Weight: 317.81
MOL File: 73-05-2.mol

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Phentolamine hydrochloride Property

Melting point:: >230 (dec.)°C
storage temp.: -20°C Freezer
solubility: methanol: 10 mg/mL, clear, colorless
form: powder
color: white to off-white
Merck: 13,7348
BRN: 3764617
CAS DataBase Reference: 73-05-2

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Safety

Hazard Codes: Xn,C
Risk Statements: 22-34
Safety Statements: 22-24/25-45-36/37/39-27-26
RIDADR: 3249
WGK Germany: 3
RTECS: SL0701000
F: 3-10
HazardClass: 6.1(b)
PackingGroup: III
Toxicity: LD50 in rats (mg/kg): 75 i.v.; 275 s.c.; 1250 orally (Meier)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: P7547
Product name: Phentolamine hydrochloride
Purity: ≥98% (TLC), powder
Packaging: 100mg
Price: $106
Updated: 2024/03/01

Sigma-Aldrich

Product number: P7547
Product name: Phentolamine hydrochloride
Purity: ≥98% (TLC), powder
Packaging: 500mg
Price: $164
Updated: 2024/03/01

TRC

Product number: P302550
Product name: Phentolamine hydrochloride
Packaging: 500mg
Price: $240
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FP26895
Product name: Phentolamine hydrochloride
Packaging: 250mg
Price: $250
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FP26895
Product name: Phentolamine hydrochloride
Packaging: 500mg
Price: $400
Updated: 2021/12/16

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Phentolamine hydrochloride Chemical Properties,Usage,Production

Chemical Properties

Phentolamine hydrochloride is Tan Solid

Originator

Regitine, Ciba, US ,1952

Uses

Phentolamine Hydrochloride ia an adrenergic blocking agent. An antihypertensive. Used for the treatment of pheochromocytoma.

Uses

anesthetic (local); inhibitor of DRG IA/Kv4.2 current

Uses

Phentolamine hydrochloride is an adrenergic blocking agent. An antihypertensive. Used for the treatment of pheochromocytoma.

Manufacturing Process

199.24 parts of N-(p-methylphenyl)-m'-hydroxyphenylamine and 77.52 parts of 2-chloromethylimidazoline hydrochloride are heated for sixteen hours in an oil bath having a temperature of 150°C, while stirring and introducing a current of nitrogen. The viscous contents of the flask are then cooled to about 100°C, mixed with 400 parts by volume of hot water, and stirred for a short time.
After further cooling to about 60°C, 200 parts by volume of water and 500 parts by volume of ethyl acetate at 60°C are added, and the aqueous layer is separated. The excess of starting material may be recovered from the ethyl acetate.
The aqueous portion is chilled in a cooling chamber at -10°C, whereupon the hydrochloride of 2-[N-(p-methylphenyl)-N-(m'-hydroxyphenyl)-aminomethyl]imidazoline crystallizes. Upon being concentrated and cooled the mother liquor yields a further quantity of the hydrochloride. The combined quantities of hydrochloride are treated with a small quantity of cold water, dried with care, and washed with ethyl acetate. The product is then crystallized from a mixture of alcohol and ethyl acetate, and there is obtained a hydrochloride melting at 239°-240°C.

brand name

Regitine Hydrochloride (Ciba-Geigy).

Therapeutic Function

Adrenergic blocker

Biochem/physiol Actions

α-adrenoceptor antagonist; peripheral vasodilator.

Phentolamine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Phentolamine hydrochloride Suppliers

Canada 1 China 47 France 1 Germany 1 India 2 Switzerland 1 United Kingdom 4 United States 17 Global 74

Alfa Chemistry

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LKT Laboratories, Inc.

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View Lastest Price from Phentolamine hydrochloride manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: PhentolaMine Hydrochloride 73-05-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20T
Release date: 2020-05-11

Dideu Industries Group Limited

Product: Phentolamine hydrochloride 73-05-2
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons min
Release date: 2021-08-12

73-05-2, Phentolamine hydrochlorideRelated Search:

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PHENTOLAMINE HYDROCHLORIDE

2-[N-(3-HYDROXYPHENYL)-4-TOLUIDINOMETHYL]-2-IMIDAZOLIDINE HYDROCHLORIDE

2-[N-(M-HYDROXYPHENYL)-P-TOLUIDINOMETHYL]IMIDAZOLINE HYDROCHLORIDE

3-(((4,5-dihydro-1h-imidazol-2-yl)methyl)(4-methylphenyl)amino)phenolhydroch

3-(((4,5-dihydro-1h-imidazol-2-yl)methyl)(4-methylphenyl)amino)-phenomonoh

c-7337

m-(n-(2-imidazolin-2-ylmethyl)-p-toluidino)-phenomonohydrochloride

phentolaminechloride

2-[n-(3-hydroxyphenyl)-p-toluidinomethyl]-2-imidazolidine hydrochloride

3-[4,5-Dihydro-1H-imidazol-2-ylmethyl-(4-methylphenyl)amino]phenol hydrochloride

Regitine hydrochloride

3-[[(4,5-Dihydro-1H-imidazol-2-yl)-methyl](4-methylphenyl)-amino]-phenol monohydrochloride

Phentolamine Hydrochloride (300 mg)

Phentolamine hydrochloride USP/EP/BP

Phentolamine Hydrochloride (1529005)

3-(((4,5-Dihydro-1H-imidazol-2-yl)methyl)(p-tolyl)amino)phenol hydrochloride

Phenol,3-[[(4,5-dihydro-1H-imidazol-2-yl)methyl](4-methylphenyl)amino]-, hydrochloride(1:1)

Phentolamine hydrochloride, Non-selective alpha antagonist

73-05-2

C17H19N2OHCl

C17H19N3OHCl

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