ChemicalBook > CAS DataBase List > 2-TERT-BUTOXYCARBONYLAMINOTHIAZOLE-4-CARBOXYLIC ACID METHYL ESTER

2-TERT-BUTOXYCARBONYLAMINOTHIAZOLE-4-CARBOXYLIC ACID METHYL ESTER

Product Name: 2-TERT-BUTOXYCARBONYLAMINOTHIAZOLE-4-CARBOXYLIC ACID METHYL ESTER
CAS No.: 850429-62-8
Chemical Name: 2-TERT-BUTOXYCARBONYLAMINOTHIAZOLE-4-CARBOXYLIC ACID METHYL ESTER
Synonyms: Methyl 2-amino-1;METHYL 2-(BOC-AMINO)THIAZOLE-4-CARBOXYLATE;METHYL 2-(BOC-AMINO)-4-THIAZOLECARBOXYLATE;N-BOC-METHYL 2-AMINO-1,3-THIAZOLE-4-CARBOXYLATE;BOC-2-AMINO-4-THIAZOLE-CARBOXYLIC ACID METHYL ESTER;METHYL 2-(TERT-BUTOXYCARBONYLAMINO)THIAZOLE-4-CARBOXYLATE;METHYL 2-AMINO-1,3-THIAZOLE-4-CARBOXYLATE, N-BOC PROTECTED;Methyl 2-amino-1,3-thiazole-4-carboxylate, 2-BOC protected;Methyl 2-amino-1,3-thiazole-4-carboxylate, 2-BOC protected 98%;Methyl 2-amino-1,3-thiazole-4-carboxylate, N-BOC protected 98%
CBNumber: CB4362193
Molecular Formula: C10H14N2O4S
Formula Weight: 258.29
MOL File: 850429-62-8.mol

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2-TERT-BUTOXYCARBONYLAMINOTHIAZOLE-4-CARBOXYLIC ACID METHYL ESTER Property

Melting point:: 156-160
storage temp.: 2-8°C
Appearance: White to off-white Solid
InChI: InChI=1S/C10H14N2O4S/c1-10(2,3)16-9(14)12-8-11-6(5-17-8)7(13)15-4/h5H,1-4H3,(H,11,12,14)
InChIKey: VLJAUDDGOCGHFB-UHFFFAOYSA-N
SMILES: S1C=C(C(OC)=O)N=C1NC(OC(C)(C)C)=O

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Safety

Hazard Codes: Xi
Hazard Note: Irritant
HS Code: 2934100090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: B657045
Product name: N-BocMethyl2-Aminothioazole-4-carboxylate
Packaging: 1g
Price: $145
Updated: 2021/12/16

Matrix Scientific

Product number: 071913
Product name: Methyl 2-Boc-aminothiazole-4-carboxylate
Purity: 95+%
Packaging: 1g
Price: $32
Updated: 2021/12/16

SynQuest Laboratories

Product number: 8H70-1-Z2
Product name: Methyl 2-amino-1,3-thiazole-4-carboxylate, 2-Boc protected
Purity: 98%
Packaging: 1g
Price: $35
Updated: 2021/12/16

SynQuest Laboratories

Product number: 8H70-1-Z2
Product name: Methyl 2-amino-1,3-thiazole-4-carboxylate, 2-Boc protected
Purity: 98%
Packaging: 5G
Price: $65
Updated: 2021/12/16

ChemScene

Product number: CS-0045352
Product name: Methyl2-Boc-aminothiazole-4-carboxylate
Purity: 96.18%
Packaging: 10g
Price: $72
Updated: 2021/12/16

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2-TERT-BUTOXYCARBONYLAMINOTHIAZOLE-4-CARBOXYLIC ACID METHYL ESTER Chemical Properties,Usage,Production

Uses

N-Boc Methyl 2-Aminothioazole-4-carboxylate a thiazolopyrimidinone derivative used as a modulator of NMDA receptor activity. Also a potential antiviral agent.

Synthesis

118452-04-3

24424-99-5

850429-62-8

General procedure for the synthesis of methyl 2-(Boc-amino)thiazole-4-carboxylate from methyl 2-aminothiazole-4-carboxylate and di-tert-butyl dicarbonate: to a 1:1 dichloromethane/tetrahydrofuran (200mL) solution containing methyl 2-aminothiazole-4-carboxylate (10.0g, 63.22mmol, prepared as described in Example 3, Step 2), was added di-tert-butyl dicarbonate butyl ester (15.2 g, 69.64 mmol) and 4-(dimethylamino)pyridine (1.5 g, 12.30 mmol). The reaction mixture was stirred at room temperature overnight. After completion of the reaction, the mixture was partitioned between ethyl acetate and 10% w/v citric acid aqueous solution. The organic layer was separated, washed sequentially with water and brine, and then dried over anhydrous sodium sulfate. The solvent was removed by concentration under reduced pressure and the crude product was purified by silica gel column chromatography to afford methyl 2-(tert-butoxycarbonylamino)thiazole-4-carboxylate as an oil (15.5 g, 95% yield) using 2:3 ethyl acetate/hexane as eluent.

References

[1] Patent: US2006/63814, 2006, A1. Location in patent: Page/Page column 61
[2] Patent: WO2015/52226, 2015, A1. Location in patent: Paragraph 0487
[3] Patent: WO2014/37480, 2014, A1. Location in patent: Page/Page column 125; 126

2-TERT-BUTOXYCARBONYLAMINOTHIAZOLE-4-CARBOXYLIC ACID METHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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2-TERT-BUTOXYCARBONYLAMINOTHIAZOLE-4-CARBOXYLIC ACID METHYL ESTER Suppliers

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850429-62-8, 2-TERT-BUTOXYCARBONYLAMINOTHIAZOLE-4-CARBOXYLIC ACID METHYL ESTERRelated Search:

5-BROMO-2-TERT-BUTOXYCARBONYLAMINOTHIAZOLE-4-CARBOXYLIC ACID METHYL ESTER, 95+% 2-TERT-BUTOXYCARBONYLAMINO-THIAZOLE-4-CARBOXYLIC ACID ETHYL ESTER 5-BROMO-2-TERT-BUTOXYCARBONYLAMINOTHIAZOLE-4-CARBOXYLIC ACID METHYL ESTER BOC-2-AMINO-4-THIAZOLE-CARBOXYLIC ACID 2-TERT-BUTOXYCARBONYLAMINOTHIAZOLE-4-CARBOXYLIC ACID METHYL ESTER (4-FORMYLTHIAZOL-2-YL)CARBAMIC ACID TERT-BUTYL ESTER tert-butyl (4-(ethoxycarbonyl)thiazol-2-yl)methylcarbamate (4-Hydroxymethylthiazol-2-yl)carbamic acid tert-butyl ester

2-TERT-BUTOXYCARBONYLAMINOTHIAZOLE-4-CARBOXYLIC ACID METHYL ESTER

METHYL 2-(TERT-BUTOXYCARBONYLAMINO)THIAZOLE-4-CARBOXYLATE

METHYL 2-AMINO-1,3-THIAZOLE-4-CARBOXYLATE, N-BOC PROTECTED

METHYL 2-(BOC-AMINO)-4-THIAZOLECARBOXYLATE

METHYL 2-(BOC-AMINO)THIAZOLE-4-CARBOXYLATE

BOC-2-AMINO-4-THIAZOLE-CARBOXYLIC ACID METHYL ESTER

Methyl 2-amino-1,3-thiazole-4-carboxylate, N-BOC protected 98%

N-BOC-METHYL 2-AMINO-1,3-THIAZOLE-4-CARBOXYLATE

Methyl 2-{[(tert-butoxy)carbonyl]aMino}-1,3-thiazole-4-carboxylate

2-[(tert-Butoxycarbonyl)amino]-4-(methoxycarbonyl)-1,3-thiazole, Methyl 2-[(tert-butoxycarbonyl)amino]-1,3-thiazole-4-carboxylate

Methyl 2-amino-1,3-thiazole-4-carboxylate, 2-BOC protected 98%

Methyl 2-amino-1

Methyl 2-amino-1,3-thiazole-4-carboxylate, 2-BOC protected

2-[[(2-methylpropan-2-yl)oxy-oxomethyl]amino]-4-thiazolecarboxylic acid methyl ester

4-Thiazolecarboxylic acid, 2-[[(1,1-dimethylethoxy)carbonyl]amino]-, methyl ester

methyl 2-[(tert-butoxycarbonyl)amino]-1,3-thiazole-4-carboxy...

850429-62-8

blocks

Carboxes

Thiazoles