tert-butyl (4-(ethoxycarbonyl)thiazol-2-yl)methylcarbamate

Product Name: tert-butyl (4-(ethoxycarbonyl)thiazol-2-yl)methylcarbamate
CAS No.: 96929-05-4
Chemical Name: tert-butyl (4-(ethoxycarbonyl)thiazol-2-yl)methylcarbamate
Synonyms: 5-(2-furyl)-1h-indazole;Ethyl 2-(Boc-aminomethyl)thiazole-4-carboxylate;tert-butyl (4-(ethoxycarbonyl)thiazol-2-yl)methylcarbamate;Ethyl 2-((tert-butoxycarbonyl)-methyl)thiazole-4-carboxylate;Ethyl 2-((tert-butoxycarbonylamino)methyl)thiazole-4-carboxylate;ethyl 2-[N-(tert-butoxycarbonyl)aminomethyl]thiazole-4-carboxylate;ethyl 2-{[(tert-butoxycarbonyl)aMino]Methyl}-1,3-thiazole-4-carboxylate;2-(((tert-butoxycarbonyl)amino)methyl)-5-ethylthiazole-4-carboxylic acid;2-(tert-Butoxycarbonylamino-methyl)-thiazole-4-carboxylic acid ethyl ester;Ethyl 2-[[(2-methylpropan-2-yl)oxycarbonylamino]methyl]-1,3-thiazole-4-carboxylate
CBNumber: CB81562396
Molecular Formula: C12H18N2O4S
Formula Weight: 286.35
MOL File: 96929-05-4.mol

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tert-butyl (4-(ethoxycarbonyl)thiazol-2-yl)methylcarbamate Property

Melting point:: 100-102 °C
Boiling point:: 401.4±25.0 °C(Predicted)
Density: 1.204±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 10.92±0.46(Predicted)
Appearance: White to off-white Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Ark Pharm

Product number: P000232090
Product name: Ethyl 2-(((tert-butoxycarbonyl)amino)methyl)thiazole-4-carboxylate
Purity: 98%
Packaging: 1g
Price: $138
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0384407
Product name: ETHYL-2-((TERT-BUTOXYCARBONYLAMINO)METHYL)THIAZOLE-4-CARBOXYLATE
Purity: 95.00%
Packaging: 5MG
Price: $496.32
Updated: 2021/12/16

Ark Pharm

Product number: P000232090
Product name: Ethyl 2-(((tert-butoxycarbonyl)amino)methyl)thiazole-4-carboxylate
Purity: 98%
Packaging: 5g
Price: $547
Updated: 2021/12/16

AK Scientific

Product number: W9818
Product name: Ethyl2-(Boc-aminomethyl)thiazole-4-carboxylate
Packaging: 5g
Price: $676
Updated: 2021/12/16

Ark Pharm

Product number: P000232090
Product name: Ethyl 2-(((tert-butoxycarbonyl)amino)methyl)thiazole-4-carboxylate
Purity: 98%
Packaging: 250mg
Price: $56
Updated: 2021/12/16

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tert-butyl (4-(ethoxycarbonyl)thiazol-2-yl)methylcarbamate Chemical Properties,Usage,Production

Synthesis

70-23-5

89226-13-1

96929-05-4

Method A: 24.6 mmol of ethyl 3-bromopyruvate was slowly added to a 47 mL solution of isopropanol containing 5.0 g (24.2 mmol) of tert-butyl (2-amino-2-thioethyl)carbamate at 20-25 °C. The reaction mixture was stirred continuously at this temperature for 5 hours. Subsequently, 24.0 mmol of a 20% aqueous sodium hydroxide solution was added to the reaction system. Upon completion of the reaction, the organic phase was separated by extraction using methyl tert-butyl ether. The organic phase was washed sequentially with water and saturated sodium chloride solution and dried over anhydrous sodium sulfate. The solvent was removed by distillation under reduced pressure to give 6.2 g of ethyl 2-((tert-butoxycarbonylamino)methyl)thiazole-4-carboxylate in 89.6% yield. The product was characterized by 1H-NMR (DMSO-d6, ppm): 8.41 (s, 1H, Ar-H), 7.86 (t, br, NH), 4.41 (d, 2H, CH2), 4.30 (q, 2H, CH2), 1.40 (s, 9H, tert-butyl), 1.30 (t, 3H, CH3).

References

[1] Tetrahedron, 1988, vol. 44, # 18, p. 5833 - 5844
[2] Synlett, 2008, # 15, p. 2379 - 2383
[3] Patent: US6642388, 2003, B1. Location in patent: Page/Page column 9
[4] Tetrahedron, 2018, vol. 74, # 5, p. 549 - 555
[5] Patent: CN103601742, 2016, B. Location in patent: Paragraph 0124-0126

tert-butyl (4-(ethoxycarbonyl)thiazol-2-yl)methylcarbamate Preparation Products And Raw materials

Raw materials

Preparation Products

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tert-butyl (4-(ethoxycarbonyl)thiazol-2-yl)methylcarbamate Suppliers

China 70 Germany 2 India 2 United States 11 Global 85

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View Lastest Price from tert-butyl (4-(ethoxycarbonyl)thiazol-2-yl)methylcarbamate manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: Ethyl 2-((tert-butoxycarbonylamino)methyl)thiazole-4-carboxylate 96929-05-4
Price: US $2.20-8.80/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-06-17

Career Henan Chemical Co

Product: tert-butyl (4-(ethoxycarbonyl)thiazol-2-yl)methylcarbamate 96929-05-4
Price: US $1.00/g
Min. Order: 1g
Purity: 98%min
Supply Ability: G/KG/T
Release date: 2019-12-20

96929-05-4, tert-butyl (4-(ethoxycarbonyl)thiazol-2-yl)methylcarbamateRelated Search:

tert-butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoromethyl)benzylcarbamate (4-Amino-phenyl)-methyl-carbamic acid tert-butyl ester Carbamic acid, N-(4-formyl-3-hydroxyphenyl)-, 1,1-dimethylethyl ester (4-OXO-4-PHENYL-BUTYL)-CARBAMIC ACID TERT-BUTYL ESTER tert-Butyl (4-bromo-7-fluorobenzo[d]thiazol-2-yl)carbamate [4-(6-FORMYLPYRIDIN-2-YL)PHENYL]CARBAMIC ACID TERT-BUTYL ESTER Carbamic acid, N-[4-(difluoromethyl)-2-thiazolyl]-, 1,1-dimethylethyl ester (5-AMINO-2-METHYL-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER (4-FORMYLTHIAZOL-2-YL)CARBAMIC ACID TERT-BUTYL ESTER 4-Thiazolecarboxylicacid,2-(aminomethyl)-,ethylester(9CI) (4-Hydroxymethylthiazol-2-yl)carbamic acid tert-butyl ester tert-butyl (4-(ethoxycarbonyl)thiazol-2-yl)methylcarbamate BOC-2-AMINO-4-THIAZOLE-CARBOXYLIC ACID 2-TERT-BUTOXYCARBONYLAMINOTHIAZOLE-4-CARBOXYLIC ACID METHYL ESTER 2-[[(TERT-BUTOXYCARBONYL)AMINO]METHYL]THIAZOLE-4-CARBOXYLIC ACID

tert-butyl (4-(ethoxycarbonyl)thiazol-2-yl)methylcarbamate

Ethyl 2-(Boc-aminomethyl)thiazole-4-carboxylate

Ethyl 2-((tert-butoxycarbonylamino)methyl)thiazole-4-carboxylate

Ethyl 2-((tert-butoxycarbonyl)-methyl)thiazole-4-carboxylate

ethyl 2-{[(tert-butoxycarbonyl)aMino]Methyl}-1,3-thiazole-4-carboxylate

ethyl 2-[N-(tert-butoxycarbonyl)aminomethyl]thiazole-4-carboxylate

5-(2-furyl)-1h-indazole

2-(((tert-butoxycarbonyl)amino)methyl)-5-ethylthiazole-4-carboxylic acid

2-(tert-Butoxycarbonylamino-methyl)-thiazole-4-carboxylic acid ethyl ester

Ethyl 2-[[(2-methylpropan-2-yl)oxycarbonylamino]methyl]-1,3-thiazole-4-carboxylate

4-Thiazolecarboxylic acid, 2-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-, ethyl ester

96929-05-4

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