(4-Amino-phenyl)-methyl-carbamic acid tert-butyl ester
- Product Name
- (4-Amino-phenyl)-methyl-carbamic acid tert-butyl ester
- CAS No.
- 1092522-02-5
- Chemical Name
- (4-Amino-phenyl)-methyl-carbamic acid tert-butyl ester
- Synonyms
- N1-Boc-N1-methyl-1,4-benzenediamine;tert-Butyl (4-aminophenyl)(methyl)carbamate;tert-Butyl N-(4-aminophenyl)-N-methylcarbamate;(4-Amino-phenyl)-methyl-carbamic acid tert-butyl ester;Carbamic acid, N-(4-aminophenyl)-N-methyl-, 1,1-dimethylethyl ester
- CBNumber
- CB92728583
- Molecular Formula
- C12H18N2O2
- Formula Weight
- 222.28
- MOL File
- 1092522-02-5.mol
(4-Amino-phenyl)-methyl-carbamic acid tert-butyl ester Property
- Boiling point:
- 346.5±25.0 °C(Predicted)
- Density
- 1.115±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 5.31±0.10(Predicted)
- Appearance
- Light yellow to yellow Solid
Safety
- HS Code
- 2934208090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A635038
- Product name
- (4-Amino-phenyl)-methyl-carbamicAcidtert-ButylEster
- Packaging
- 100mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- 8738AH
- Product name
- (4-Amino-phenyl)-methyl-carbamicacidtert-butylester
- Packaging
- 250mg
- Price
- $162
- Updated
- 2021/12/16
- Product number
- OR346359
- Product name
- (4-Amino-phenyl)-methyl-carbamic acid tert-butyl ester
- Packaging
- 1g
- Price
- $246
- Updated
- 2021/12/16
- Product number
- 8738AH
- Product name
- (4-Amino-phenyl)-methyl-carbamicacidtert-butylester
- Packaging
- 1g
- Price
- $281
- Updated
- 2021/12/16
- Product number
- 130061
- Product name
- (4-Amino-phenyl)-methyl-carbamicacidtert-butylester
- Purity
- 95%+
- Packaging
- 1g
- Price
- $450
- Updated
- 2021/12/16
(4-Amino-phenyl)-methyl-carbamic acid tert-butyl ester Chemical Properties,Usage,Production
Synthesis
474020-88-7
1092522-02-5
The general procedure for the synthesis of tert-butyl (4-aminophenyl)methylcarbamate from tert-butyl methyl(4-nitrophenyl)carbamate was as follows: to a mixed solution of THF/MeOH/H2O (150 mL/40 mL/80 mL) containing methyl tert-butyl(4-nitrophenyl)carbamate (8.3 g, 32.9 mmol) was added iron powder (9.4 g), 168 mmol, and ammonium chloride (18 g, 337 mmol), in sequence. (168 mmol) and ammonium chloride (18 g, 337 mmol). The reaction mixture was heated and stirred at 50 °C for 4 h under nitrogen protection. After completion of the reaction, it was cooled to room temperature and filtered through a diatomaceous earth pad to remove solid impurities. The filtrate was extracted with ethyl acetate (100 mL x 3), and the organic phases were combined, washed sequentially with water and saturated saline, and dried over anhydrous sodium sulfate. The organic phase was concentrated under reduced pressure to afford the target product tert-butyl (4-aminophenyl)methylcarbamate (7.3 g, 100% yield) as a yellow solid. The product was analyzed by LC-MS (ESI) with m/z (M + 1) of 223.
References
[1] Patent: US2013/197014, 2013, A1. Location in patent: Paragraph 0734; 0735
[2] Bioorganic and Medicinal Chemistry, 2008, vol. 16, # 23, p. 10034 - 10042
[3] Patent: EP2409977, 2012, A1. Location in patent: Page/Page column 124
[4] ACS Medicinal Chemistry Letters, 2015, vol. 6, # 2, p. 112 - 116
[5] Patent: , 2016, . Location in patent: Paragraph 0039; 0077; 0078; 0079
(4-Amino-phenyl)-methyl-carbamic acid tert-butyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
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