(4-Amino-phenyl)-methyl-carbamic acid tert-butyl ester

Product Name: (4-Amino-phenyl)-methyl-carbamic acid tert-butyl ester
CAS No.: 1092522-02-5
Chemical Name: (4-Amino-phenyl)-methyl-carbamic acid tert-butyl ester
Synonyms: N1-Boc-N1-methyl-1,4-benzenediamine;tert-Butyl (4-aminophenyl)(methyl)carbamate;tert-Butyl N-(4-aminophenyl)-N-methylcarbamate;(4-Amino-phenyl)-methyl-carbamic acid tert-butyl ester;Carbamic acid, N-(4-aminophenyl)-N-methyl-, 1,1-dimethylethyl ester
CBNumber: CB92728583
Molecular Formula: C12H18N2O2
Formula Weight: 222.28
MOL File: 1092522-02-5.mol

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(4-Amino-phenyl)-methyl-carbamic acid tert-butyl ester Property

Boiling point:: 346.5±25.0 °C(Predicted)
Density: 1.115±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 5.31±0.10(Predicted)
Appearance: Light yellow to yellow Solid

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Safety

HS Code: 2934208090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: A635038
Product name: (4-Amino-phenyl)-methyl-carbamicAcidtert-ButylEster
Packaging: 100mg
Price: $65
Updated: 2021/12/16

AK Scientific

Product number: 8738AH
Product name: (4-Amino-phenyl)-methyl-carbamicacidtert-butylester
Packaging: 250mg
Price: $162
Updated: 2021/12/16

Apolloscientific

Product number: OR346359
Product name: (4-Amino-phenyl)-methyl-carbamic acid tert-butyl ester
Packaging: 1g
Price: $246
Updated: 2021/12/16

AK Scientific

Product number: 8738AH
Product name: (4-Amino-phenyl)-methyl-carbamicacidtert-butylester
Packaging: 1g
Price: $281
Updated: 2021/12/16

Matrix Scientific

Product number: 130061
Product name: (4-Amino-phenyl)-methyl-carbamicacidtert-butylester
Purity: 95%+
Packaging: 1g
Price: $450
Updated: 2021/12/16

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(4-Amino-phenyl)-methyl-carbamic acid tert-butyl ester Chemical Properties,Usage,Production

Synthesis

474020-88-7

1092522-02-5

The general procedure for the synthesis of tert-butyl (4-aminophenyl)methylcarbamate from tert-butyl methyl(4-nitrophenyl)carbamate was as follows: to a mixed solution of THF/MeOH/H2O (150 mL/40 mL/80 mL) containing methyl tert-butyl(4-nitrophenyl)carbamate (8.3 g, 32.9 mmol) was added iron powder (9.4 g), 168 mmol, and ammonium chloride (18 g, 337 mmol), in sequence. (168 mmol) and ammonium chloride (18 g, 337 mmol). The reaction mixture was heated and stirred at 50 °C for 4 h under nitrogen protection. After completion of the reaction, it was cooled to room temperature and filtered through a diatomaceous earth pad to remove solid impurities. The filtrate was extracted with ethyl acetate (100 mL x 3), and the organic phases were combined, washed sequentially with water and saturated saline, and dried over anhydrous sodium sulfate. The organic phase was concentrated under reduced pressure to afford the target product tert-butyl (4-aminophenyl)methylcarbamate (7.3 g, 100% yield) as a yellow solid. The product was analyzed by LC-MS (ESI) with m/z (M + 1) of 223.

References

[1] Patent: US2013/197014, 2013, A1. Location in patent: Paragraph 0734; 0735
[2] Bioorganic and Medicinal Chemistry, 2008, vol. 16, # 23, p. 10034 - 10042
[3] Patent: EP2409977, 2012, A1. Location in patent: Page/Page column 124
[4] ACS Medicinal Chemistry Letters, 2015, vol. 6, # 2, p. 112 - 116
[5] Patent: , 2016, . Location in patent: Paragraph 0039; 0077; 0078; 0079

(4-Amino-phenyl)-methyl-carbamic acid tert-butyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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(4-Amino-phenyl)-methyl-carbamic acid tert-butyl ester Suppliers

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