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tert-butyl (4-(ethoxycarbonyl)thiazol-2-yl)methylcarbamate

Product Name
tert-butyl (4-(ethoxycarbonyl)thiazol-2-yl)methylcarbamate
CAS No.
96929-05-4
Chemical Name
tert-butyl (4-(ethoxycarbonyl)thiazol-2-yl)methylcarbamate
Synonyms
5-(2-furyl)-1h-indazole;Ethyl 2-(Boc-aminomethyl)thiazole-4-carboxylate;tert-butyl (4-(ethoxycarbonyl)thiazol-2-yl)methylcarbamate;Ethyl 2-((tert-butoxycarbonyl)-methyl)thiazole-4-carboxylate;Ethyl 2-((tert-butoxycarbonylamino)methyl)thiazole-4-carboxylate;ethyl 2-[N-(tert-butoxycarbonyl)aminomethyl]thiazole-4-carboxylate;ethyl 2-{[(tert-butoxycarbonyl)aMino]Methyl}-1,3-thiazole-4-carboxylate;2-(((tert-butoxycarbonyl)amino)methyl)-5-ethylthiazole-4-carboxylic acid;2-(tert-Butoxycarbonylamino-methyl)-thiazole-4-carboxylic acid ethyl ester;Ethyl 2-[[(2-methylpropan-2-yl)oxycarbonylamino]methyl]-1,3-thiazole-4-carboxylate
CBNumber
CB81562396
Molecular Formula
C12H18N2O4S
Formula Weight
286.35
MOL File
96929-05-4.mol
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tert-butyl (4-(ethoxycarbonyl)thiazol-2-yl)methylcarbamate Property

Melting point:
100-102 °C
Boiling point:
401.4±25.0 °C(Predicted)
Density 
1.204±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
pka
10.92±0.46(Predicted)
Appearance
White to off-white Solid
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Ark Pharm
Product number
P000232090
Product name
Ethyl 2-(((tert-butoxycarbonyl)amino)methyl)thiazole-4-carboxylate
Purity
98%
Packaging
1g
Price
$138
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0384407
Product name
ETHYL-2-((TERT-BUTOXYCARBONYLAMINO)METHYL)THIAZOLE-4-CARBOXYLATE
Purity
95.00%
Packaging
5MG
Price
$496.32
Updated
2021/12/16
Ark Pharm
Product number
P000232090
Product name
Ethyl 2-(((tert-butoxycarbonyl)amino)methyl)thiazole-4-carboxylate
Purity
98%
Packaging
5g
Price
$547
Updated
2021/12/16
AK Scientific
Product number
W9818
Product name
Ethyl2-(Boc-aminomethyl)thiazole-4-carboxylate
Packaging
5g
Price
$676
Updated
2021/12/16
Ark Pharm
Product number
P000232090
Product name
Ethyl 2-(((tert-butoxycarbonyl)amino)methyl)thiazole-4-carboxylate
Purity
98%
Packaging
250mg
Price
$56
Updated
2021/12/16
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tert-butyl (4-(ethoxycarbonyl)thiazol-2-yl)methylcarbamate Chemical Properties,Usage,Production

Synthesis

70-23-5

89226-13-1

96929-05-4

Method A: 24.6 mmol of ethyl 3-bromopyruvate was slowly added to a 47 mL solution of isopropanol containing 5.0 g (24.2 mmol) of tert-butyl (2-amino-2-thioethyl)carbamate at 20-25 °C. The reaction mixture was stirred continuously at this temperature for 5 hours. Subsequently, 24.0 mmol of a 20% aqueous sodium hydroxide solution was added to the reaction system. Upon completion of the reaction, the organic phase was separated by extraction using methyl tert-butyl ether. The organic phase was washed sequentially with water and saturated sodium chloride solution and dried over anhydrous sodium sulfate. The solvent was removed by distillation under reduced pressure to give 6.2 g of ethyl 2-((tert-butoxycarbonylamino)methyl)thiazole-4-carboxylate in 89.6% yield. The product was characterized by 1H-NMR (DMSO-d6, ppm): 8.41 (s, 1H, Ar-H), 7.86 (t, br, NH), 4.41 (d, 2H, CH2), 4.30 (q, 2H, CH2), 1.40 (s, 9H, tert-butyl), 1.30 (t, 3H, CH3).

References

[1] Tetrahedron, 1988, vol. 44, # 18, p. 5833 - 5844
[2] Synlett, 2008, # 15, p. 2379 - 2383
[3] Patent: US6642388, 2003, B1. Location in patent: Page/Page column 9
[4] Tetrahedron, 2018, vol. 74, # 5, p. 549 - 555
[5] Patent: CN103601742, 2016, B. Location in patent: Paragraph 0124-0126

tert-butyl (4-(ethoxycarbonyl)thiazol-2-yl)methylcarbamate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from tert-butyl (4-(ethoxycarbonyl)thiazol-2-yl)methylcarbamate manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
Ethyl 2-((tert-butoxycarbonylamino)methyl)thiazole-4-carboxylate 96929-05-4
Price
US $2.20-8.80/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2025-06-17
Career Henan Chemical Co
Product
tert-butyl (4-(ethoxycarbonyl)thiazol-2-yl)methylcarbamate 96929-05-4
Price
US $1.00/g
Min. Order
1g
Purity
98%min
Supply Ability
G/KG/T
Release date
2019-12-20

96929-05-4, tert-butyl (4-(ethoxycarbonyl)thiazol-2-yl)methylcarbamateRelated Search:

tert-butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoromethyl)benzylcarbamate (4-Amino-phenyl)-methyl-carbamic acid tert-butyl ester Carbamic acid, N-(4-formyl-3-hydroxyphenyl)-, 1,1-dimethylethyl ester (4-OXO-4-PHENYL-BUTYL)-CARBAMIC ACID TERT-BUTYL ESTER tert-Butyl (4-bromo-7-fluorobenzo[d]thiazol-2-yl)carbamate [4-(6-FORMYLPYRIDIN-2-YL)PHENYL]CARBAMIC ACID TERT-BUTYL ESTER Carbamic acid, N-[4-(difluoromethyl)-2-thiazolyl]-, 1,1-dimethylethyl ester (5-AMINO-2-METHYL-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER (4-FORMYLTHIAZOL-2-YL)CARBAMIC ACID TERT-BUTYL ESTER 4-Thiazolecarboxylicacid,2-(aminomethyl)-,ethylester(9CI) (4-Hydroxymethylthiazol-2-yl)carbamic acid tert-butyl ester tert-butyl (4-(ethoxycarbonyl)thiazol-2-yl)methylcarbamate BOC-2-AMINO-4-THIAZOLE-CARBOXYLIC ACID 2-TERT-BUTOXYCARBONYLAMINOTHIAZOLE-4-CARBOXYLIC ACID METHYL ESTER 2-[[(TERT-BUTOXYCARBONYL)AMINO]METHYL]THIAZOLE-4-CARBOXYLIC ACID

  • tert-butyl (4-(ethoxycarbonyl)thiazol-2-yl)methylcarbamate
  • Ethyl 2-(Boc-aminomethyl)thiazole-4-carboxylate
  • Ethyl 2-((tert-butoxycarbonylamino)methyl)thiazole-4-carboxylate
  • Ethyl 2-((tert-butoxycarbonyl)-methyl)thiazole-4-carboxylate
  • ethyl 2-{[(tert-butoxycarbonyl)aMino]Methyl}-1,3-thiazole-4-carboxylate
  • ethyl 2-[N-(tert-butoxycarbonyl)aminomethyl]thiazole-4-carboxylate
  • 5-(2-furyl)-1h-indazole
  • 2-(((tert-butoxycarbonyl)amino)methyl)-5-ethylthiazole-4-carboxylic acid
  • 2-(tert-Butoxycarbonylamino-methyl)-thiazole-4-carboxylic acid ethyl ester
  • Ethyl 2-[[(2-methylpropan-2-yl)oxycarbonylamino]methyl]-1,3-thiazole-4-carboxylate
  • 4-Thiazolecarboxylic acid, 2-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-, ethyl ester
  • 96929-05-4
  • CHIRAL CHEMICALS