1-BROMO-2,6-DIMETHOXYBENZENE

Product Name: 1-BROMO-2,6-DIMETHOXYBENZENE
CAS No.: 16932-45-9
Chemical Name: 1-BROMO-2,6-DIMETHOXYBENZENE
Synonyms: 2-Bromo-3-methoxyanisole;1,3-Dimethoxy-2-bromobenzene;1-BROMO-2,6-DIMETHOXYBENZENE;2-BROMO-1,3-DIMETHOXY-BENZENE;Benzene, 2-bromo-1,3-dimethoxy-;2-Bromo-1,3-dimethoxybenzene >2-Bromo-3-methoxyanisole
CBNumber: CB4362375
Molecular Formula: C8H9BrO2
Formula Weight: 217.06
MOL File: 16932-45-9.mol

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1-BROMO-2,6-DIMETHOXYBENZENE Property

Melting point:: 91-94°C
Boiling point:: 250℃
Density: 1.412
Flash point:: 106℃
storage temp.: Inert atmosphere,Room Temperature
form: powder to crystal
color: White to Orange to Green
Water Solubility: Insoluble in water.
InChI: InChI=1S/C8H9BrO2/c1-10-6-4-3-5-7(11-2)8(6)9/h3-5H,1-2H3
InChIKey: VHVYSMMZHORFKU-UHFFFAOYSA-N
SMILES: C1(OC)=CC=CC(OC)=C1Br

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Safety

Hazard Codes: Xn
Risk Statements: 22
WGK Germany: 3
HS Code: 2909.30.6000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: B3488
Product name: 2-Bromo-1,3-dimethoxybenzene
Purity: >98.0%(GC)
Packaging: 1g
Price: $39
Updated: 2025/07/31

TCI Chemical

Product number: B3488
Product name: 2-Bromo-1,3-dimethoxybenzene
Purity: >98.0%(GC)
Packaging: 5g
Price: $120
Updated: 2025/07/31

TCI Chemical

Product number: B3488
Product name: 2-Bromo-1,3-dimethoxybenzene
Purity: >98.0%(GC)
Packaging: 25g
Price: $423
Updated: 2025/07/31

TRC

Product number: B997325
Product name: 2-Bromo-1,3-dimethoxybenzene
Packaging: 500mg
Price: $90
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB139209
Product name: 2-Bromo-1,3-dimethoxybenzene
Packaging: 10g
Price: $100
Updated: 2021/12/16

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1-BROMO-2,6-DIMETHOXYBENZENE Chemical Properties,Usage,Production

Chemical Properties

off-white crystalline solid

Uses

2-Bromo-1,3-dimethoxybenzene is used as a pharmaceutical intermediate.

Synthesis

151-10-0

16932-45-9

The general procedure for the synthesis of 2,6-dimethoxybromobenzene from m-anisidine is as follows: Example Preparation Example (A) Synthesis of intermediate (A) (A-1) Synthesis of 1-bromo-2,6-dimethoxybenzene Under argon protection, 19.3 g of 1,3-dimethoxybenzene and 500 mL of anhydrous ether were added to a flask. 105 mL (1.6 M) of hexane solution of n-butyllithium was slowly added and the reaction mixture was heated and stirred for 4 hours. Upon completion of the reaction, the mixture was cooled to room temperature, followed by further cooling to -50°C. At this temperature, 25 g of bromine was slowly added dropwise. After the dropwise addition was completed, the reaction mixture was gradually warmed to room temperature and stirring was continued for 2 hours. At the end of the reaction, 300 mL of 10% aqueous sodium thiosulfate solution was added and stirred for 1 hour to quench the reaction. The reaction mixture was extracted with ether, and the organic phase was separated and washed with saturated brine. The organic phase was dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography. The resulting crystals were washed with hexane to give 17.9 g (yield: 52%) of white crystals of 1-bromo-2,6-dimethoxybenzene.

References

[1] Journal of the Chemical Society, Chemical Communications, 1995, # 6, p. 611 - 612
[2] Journal of Organic Chemistry, 2006, vol. 71, # 2, p. 775 - 788
[3] Patent: EP2436679, 2012, A1. Location in patent: Page/Page column 46
[4] Patent: JP2015/7036, 2015, A. Location in patent: Paragraph 0234; 0236
[5] Helvetica Chimica Acta, 1990, vol. 73, # 1, p. 48 - 62

1-BROMO-2,6-DIMETHOXYBENZENE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-BROMO-2,6-DIMETHOXYBENZENE Suppliers

Americas 1 China 133 Europe 1 India 8 Japan 1 United Kingdom 2 United States 14 Global 160

J & K SCIENTIFIC LTD.

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View Lastest Price from 1-BROMO-2,6-DIMETHOXYBENZENE manufacturers

Henan Fengda Chemical Co., Ltd

Product: 1-Bromo-2,6-dimethoxybenzene 16932-45-9
Price: US $200.00-1.00/KG
Min. Order: 1KG
Purity: 99%, 99.5% Sublimated
Supply Ability: g-kg-tons, free sample is available
Release date: 2023-12-30

Zibo Shiji Zhonglian Medical Technology Co., Ltd.

Product: 1-BROMO-2,6-DIMETHOXYBENZENE 16932-45-9
Price: US $0.00/KG
Min. Order: 25KG
Purity: 99.0%
Supply Ability: 1000KG/th
Release date: 2023-06-16

Honest Joy Holdings Limited

Product: 2-Bromo-1,3-dimethoxybenzene 16932-45-9
Price: US $0.00/KG
Min. Order: 1KG
Purity: 97.2%
Supply Ability: 100 tons
Release date: 2022-01-14

16932-45-9, 1-BROMO-2,6-DIMETHOXYBENZENERelated Search:

4-BROMO-3,5-DIMETHOXYBENZYL ALCOHOL 4-BROMO-3,5-DIMETHOXYBENZOIC ACID Brodimoprim METHYL 3,5-DIBROMO-2,4-DIMETHOXY-6-METHYLBENZOATE 1-BROMO-2,6-DIMETHOXYBENZENE 4-BROMO-3,5-DIMETHOXYBENZALDEHYDE 1-BROMO-2,3-DIMETHOXYBENZENE 1-Bromo-3,5-dimethoxybenzene,1-BROMO-3 5-DIMETHOXYBENZENE 97 5-Bromo-1,4-dimethoxybenzene,1-BROMO-2,5-DIMETHOXYBENZENE,2-Bromo-1,4-dimethoxybenzene,1-Bromo-2,5-dimethoxybenzene,98%,1-BROMO-2,5-DIMETHOXYBENZENE 98% 4-Bromo-1,3-dimethoxybenzene,1-BROMO-2 4-DIMETHOXYBENZENE 96%,1-Bromo-2,4-dimethoxybenzene, GC 98%,1-BROMO-2,4-DIMETHOXYBENZENE 1-BROMO-3,4-DIMETHOXYBENZENE / 4-BROMOVERATROLE,1-BROMO-3,4-DIMETHOXYBENZENE,4-BROMO-1,2-DIMETHOXYBENZENE 1-BROMO-2,4,6-TRIMETHOXYBENZENE 4-BROMO-3,5-DIMETHOXYBENZOIC ACID METHYL ESTER 5(6)-CARBOXYEOSIN DIACETATE N-HYDROXY-SUCCINIMIDE ESTER 4-BROMO-3,5-DIMETHOXYBENZOYL HYDRAZINE 2,4,6-TRIBROMO-3,5-DIMETHOXYPHENOL EOSIN DIACETATE 5(6)-CARBOXYEOSIN DIACETATE

2-BROMO-1,3-DIMETHOXY-BENZENE

1-BROMO-2,6-DIMETHOXYBENZENE

1,3-Dimethoxy-2-bromobenzene

2-Bromo-3-methoxyanisole

<SMALL>2-Bromo-3-methoxyanisole</SMALL>

2-Bromo-1,3-dimethoxybenzene &gt

Benzene, 2-bromo-1,3-dimethoxy-

16932-45-9