2,6-Dimethylfluorobenzene
- Product Name
- 2,6-Dimethylfluorobenzene
- CAS No.
- 443-88-9
- Chemical Name
- 2,6-Dimethylfluorobenzene
- Synonyms
- 2-FLUORO-1,3-DIMETHYLBENZENE;2-FLUORO-M-XYLENE;Fluoroxylene3;FLUORO-M-XYLENE;2-Fluoro-m-xylene>2-Fluoro-m-xylene,98%;2,6-DIMETHYLFLUOROBENZENE;2,5-DIMETHYLFLUOROBENZENE;1-FLUORO-2,6-DIMETHYLBENZENE;1,3-dimethyl-2-fluorobenzene
- CBNumber
- CB4367264
- Molecular Formula
- C8H9F
- Formula Weight
- 124.16
- MOL File
- 443-88-9.mol
2,6-Dimethylfluorobenzene Property
- Boiling point:
- 147-148 °C(lit.)
- Density
- 0.988 g/mL at 25 °C(lit.)
- refractive index
- n20/D 1.479(lit.)
- Flash point:
- 87 °F
- storage temp.
- 2-8°C
- form
- liquid
- color
- Clear, colourless
- Specific Gravity
- 0.988
- Water Solubility
- Not miscible or difficult to mix in water.
- BRN
- 1857413
- InChI
- InChI=1S/C8H9F/c1-6-4-3-5-7(2)8(6)9/h3-5H,1-2H3
- InChIKey
- JTAUTNBVFDTYTI-UHFFFAOYSA-N
- SMILES
- C1(C)=CC=CC(C)=C1F
- CAS DataBase Reference
- 443-88-9(CAS DataBase Reference)
- NIST Chemistry Reference
- 2,6-Dimethylfluorobenzene(443-88-9)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H226Flammable liquid and vapour
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 452866
- Product name
- 2-Fluoro-1,3-dimethylbenzene
- Purity
- 97%
- Packaging
- 5ml
- Price
- $87.3
- Updated
- 2023/06/20
- Product number
- F0402
- Product name
- 2-Fluoro-m-xylene
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $39
- Updated
- 2025/07/31
- Product number
- F0402
- Product name
- 2-Fluoro-m-xylene
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $189
- Updated
- 2025/07/31
- Product number
- D465758
- Product name
- 2,6-Dimethylfluorobenzene
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- D465758
- Product name
- 2,6-Dimethylfluorobenzene
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
2,6-Dimethylfluorobenzene Chemical Properties,Usage,Production
Chemical Properties
Colorless liquid
Uses
It is used in the spectroscopic observation of jet-cooled 2-fluoro-m-xylyl radical.
Synthesis Reference(s)
Journal of Medicinal Chemistry, 21, p. 906, 1978 DOI: 10.1021/jm00207a013
Synthesis
87-62-7
443-88-9
Example 2: General procedure for synthesizing 2-fluoro-1,3-dimethylbenzene from 2,6-dimethylaniline The diazotization of 2,6-dimethylaniline (2.3 g, 0.02 mol) was carried out in an Et3N-3HF system under the same conditions as for 2,4,6-trimethylaniline in Example 1. Upon initial addition of sodium nitrite (2.0 g, 0.03 mol), the color of the reaction mixture gradually changed from yellow to red. A small amount of tar is generated during the reaction, which can be easily separated by solvent extraction. The post-treatment was consistent with the description of 2,4,6-trimethylaniline. The organic layer was extracted from the aqueous phase using diethyl ether (150 mL), and the organic extract was dried over magnesium sulfate and fractionated by solvent to give an orange colored oil. The oily substance was distilled at 141-143 °C and atmospheric pressure to give the colorless liquid 1-fluoro-2,6-dimethylbenzene (2.0 g, 86.3% yield). The distillation process was completed in 1 hour. The 1H NMR (CDCl3) spectrum of the product showed: δ 2.25 (2-CH3 and 6-CH3, d, J = 2.0 Hz, 6H); δ 6.91 (3-H and 5-H, dd, J = 8.3 Hz and J = 6.5 Hz, 2H); and δ 7.01 (4-H, t, J = 8.0 Hz, 1H).19F NMR (CDCl3) spectrum was found to be at δ 122.5 (1-F, ts, J = 6.5 Hz and J = 2.0 Hz) showed signals. Mass spectrometry analysis showed the molecular ion peak at m/z 124 and characteristic fragmentation peaks of 1-fluoro-2,6-dimethylbenzene were observed at m/z 109, 103, 96, 89, 83 and 77.
References
[1] Patent: US6179970, 2001, B2
[2] Journal of the American Chemical Society, 1992, vol. 114, # 7, p. 2482 - 2494
[3] Proceedings - Indian Academy of Sciences, Section A, 1959, vol. 50, p. 51,56, 58, 59
[4] Journal of Medicinal Chemistry, 1978, vol. 21, # 9, p. 906 - 913
[5] Zeitschrift fuer Naturforschung, B: Chemical Sciences, 1995, vol. 50, # 7, p. 1075 - 1078
2,6-Dimethylfluorobenzene Preparation Products And Raw materials
Raw materials
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View Lastest Price from 2,6-Dimethylfluorobenzene manufacturers
- Product
- 2,6-Dimethylfluorobenzene 443-88-9
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-29
- Product
- 2,6-dimethylfluorobenzene 443-88-9
- Price
- US $20.00/ASSAYS
- Min. Order
- 1ASSAYS
- Purity
- 99%
- Supply Ability
- 200MT/ year
- Release date
- 2020-03-11
- Product
- 2,6-Dimethylfluorobenzene 443-88-9
- Price
- US $100.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-25