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Eliprodil

Product Name
Eliprodil
CAS No.
119431-25-3
Chemical Name
Eliprodil
Synonyms
ELIPRODIL;SL 820715;1-(4-broMophenyl)-2-(4-(4-fluorobenzyl)piperidin-1-yl)ethanol;α-(4-chlorophenyl)-4-[(4-fluorophenyl)methyl]-1-piperidineethanol;1-(4-chlorophenyl)-2-(4-(4-fluorobenzyl)piperidin-1-yl)ethan-1-ol;α-(4-Chlorophenyl)-4-[(4-fluorophenyl)Methyl]-1-piperidineethanol;(+-)-alpha-(p-Chlorophenyl)-4-(p-fluorobenzyl)-1-piperidineethanol;(+-)-alpha-(p-Chlorophenyl)-4-(p-fluorobenzyl)-1-piperidineethanol;1-Piperidineethanol, α-(4-chlorophenyl)-4-[(4-fluorophenyl)methyl]-;ALPHA-(4-CHLOROPHENYL)-4-[(4-FLUOROPHENYL)METHYL]-1-PIPERIDINEETHANOL
CBNumber
CB4373759
Molecular Formula
C20H23ClFNO
Formula Weight
347.85
MOL File
119431-25-3.mol
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Eliprodil Property

Boiling point:
474.1±35.0 °C(Predicted)
Density 
1.205±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,2-8°C
solubility 
DMSO: ~17 mg/mL
form 
solid
pka
13.99±0.20(Predicted)
color 
white
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Safety

Hazard Codes 
N
Risk Statements 
50/53
Safety Statements 
60-61
RIDADR 
UN 3077 9/PG 3
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H319Causes serious eye irritation

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
E2031
Product name
Eliprodil
Purity
≥98% (HPLC), powder
Packaging
10mg
Price
$189
Updated
2024/03/01
Sigma-Aldrich
Product number
5.04539
Product name
Eliprodil - CAS 119431-25-3 - Calbiochem
Packaging
10mg
Price
$90
Updated
2024/03/01
Sigma-Aldrich
Product number
E2031
Product name
Eliprodil
Purity
≥98% (HPLC), powder
Packaging
50mg
Price
$660
Updated
2023/01/07
Cayman Chemical
Product number
18398
Product name
Eliprodil
Purity
≥98%
Packaging
5mg
Price
$61
Updated
2024/03/01
Cayman Chemical
Product number
18398
Product name
Eliprodil
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2023/01/06
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Eliprodil Chemical Properties,Usage,Production

Description

N-Methyl-D-aspartate (NMDA) receptors are calcium permeable ligand-gated channels of the central nervous system that are activated after binding of the co-agonists glutamate and glycine. Eliprodil is a non-competitive NMDA receptor antagonist that inhibits neuronal calcium channel currents. It is selective for NR2B subunit-containing receptors (IC50 = 1 μM), displaying greater than 100-fold selectivity for NR2B over NR2A and NR2C subunits. Eliprodil also avidly binds σ1 and σ2 sites (Kis = 0.013 and 0.63 μM, respectively). It is effective in vivo, blocking ischemia-induced neurodegeneration in the CA1 region of the hippocampus of gerbils subjected to bilateral carotid artery occlusion. Eliprodil can also have proarrhythmic actions in hearts under normal conditions.

Uses

Eliprodil is a noncardiac drug with neuroprotective properties. It is also a N-Methyl-D-aspartate receptor (NMDAR) antagonist.

Definition

ChEBI: Eliprodil is a racemate comprising equimolar amounts of (R)- and (S)-eliprodil. It is a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist and an anti-ischaemic agent that exhibits neuroprotective properties. It has a role as a geroprotector, a NMDA receptor antagonist, a neuroprotective agent and a calcium channel blocker. It contains a (R)-eliprodil and a (S)-eliprodil.

Biological Activity

Non-competitive NMDA receptor antagonist that acts at the polyamine modulatory site. Selective for NR2B- over NR2A- and NR2C-containing receptors (IC 50 values are 1, > 100 and > 100 μ M respectively). Also σ 1 ligand (K i = 0.013 μ M). Antagonizes neuronal voltage-gated Ca 2+ channels and selectively inhibits the rapid component of the delayed rectifier K + current (I Kr ). Neuroprotective.

Biological Activity

Eliprodil (SL-820715) is a non-competitive, NR2B-selective NMDA antagonist with IC50 of 1 μM. Its IC50 is greater than 100 μM for receptors containing NR2A and NR2C.

storage

+4°C (desiccate)

Eliprodil Preparation Products And Raw materials

Raw materials

Preparation Products

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Eliprodil Suppliers

China 91 Europe 1 Germany 3 India 1 Switzerland 1 United Kingdom 2 United States 16 Global 115
VDM Biochemicals
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0330-2528181
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888-539-0666
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857-239-0968
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marketing@targetmol.com
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View Lastest Price from Eliprodil manufacturers

Career Henan Chemical Co
Product
ALPHA-(4-CHLOROPHENYL)-4-[(4-FLUOROPHENYL)METHYL]-1-PIPERIDINEETHANOL 119431-25-3
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1lg; 2kg; 5kg; 10kg; 100kg
Release date
2019-08-31

119431-25-3, EliprodilRelated Search:

7-Hydroxyisoflavone (7β,11α,17α)-9,11-Epoxy-17-hydroxy-3-oxo-pregn-4-ene-7,21-dicarboxylic Acid γ-Lactone Methyl Ester Serotonin hydrochloride (R)-Eliprodil (S)-Eliprodil 4-(PHENYLMETHYL)-PIPERIDINE HYDROCHLORIDE 4-(4-FLUOROBENZYL)PIPERIDINE HYDROCHLORIDE 4-(4'-Fluorobenzyl)piperidine Eliprodil

  • SL 820715
  • ALPHA-(4-CHLOROPHENYL)-4-[(4-FLUOROPHENYL)METHYL]-1-PIPERIDINEETHANOL
  • ELIPRODIL
  • α-(4-chlorophenyl)-4-[(4-fluorophenyl)methyl]-1-piperidineethanol
  • SL 820715, α-(4-Chlorophenyl)-4-[(4-fluorophenyl)methyl]-1-piperidineethanol
  • (+-)-alpha-(p-Chlorophenyl)-4-(p-fluorobenzyl)-1-piperidineethanol
  • 1-(4-broMophenyl)-2-(4-(4-fluorobenzyl)piperidin-1-yl)ethanol
  • 1-Piperidineethanol, α-(4-chlorophenyl)-4-[(4-fluorophenyl)methyl]-
  • α-(4-Chlorophenyl)-4-[(4-fluorophenyl)Methyl]-1-piperidineethanol
  • 1-(4-chlorophenyl)-2-(4-(4-fluorobenzyl)piperidin-1-yl)ethan-1-ol
  • (+-)-alpha-(p-Chlorophenyl)-4-(p-fluorobenzyl)-1-piperidineethanol
  • 119431-25-3
  • C20H23ClFNO
  • Cell Biology
  • BioChemical
  • Cell Signaling and Neuroscience
  • Ionotropic Glutamate Receptor Modulators
  • Ion Channels
  • Ligand-Gated Ion Channels
  • Inhibitors
  • Glutamate receptor
  • Neuroprotective agent.