ChemicalBook > CAS DataBase List > 1-Chloro-3-methanesulfonyl-6,6-dimethyl-6,7-dihydro-5H-benzo[c]thiophen-4-one

1-Chloro-3-methanesulfonyl-6,6-dimethyl-6,7-dihydro-5H-benzo[c]thiophen-4-one

Product Name
1-Chloro-3-methanesulfonyl-6,6-dimethyl-6,7-dihydro-5H-benzo[c]thiophen-4-one
CAS No.
882288-28-0
Chemical Name
1-Chloro-3-methanesulfonyl-6,6-dimethyl-6,7-dihydro-5H-benzo[c]thiophen-4-one
Synonyms
AI-3;AI 3,AI3;1-Chloro-3-methanesulfonyl-6,6-dimethyl-6,7-dihydro-5H-benzo[c]thiophen-4-one;1-Chloro-6,7-dihydro-6,6-dimethyl-3-(methylsulfonyl)-benzo[c]thiophen-4(5H)-one;Benzo[c]thiophen-4(5H)-one, 1-chloro-6,7-dihydro-6,6-dimethyl-3-(methylsulfonyl)-
CBNumber
CB43836091
Molecular Formula
C11H13ClO3S2
Formula Weight
292.8
MOL File
882288-28-0.mol
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1-Chloro-3-methanesulfonyl-6,6-dimethyl-6,7-dihydro-5H-benzo[c]thiophen-4-one Property

storage temp. 
-20°C
solubility 
Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 25 mg/ml).
form 
solid
color 
White
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris
Product number
5145
Product name
AI-3
Purity
≥98%(HPLC)
Packaging
10
Price
$180
Updated
2021/12/16
Tocris
Product number
5145
Product name
AI-3
Purity
≥98%(HPLC)
Packaging
50
Price
$749
Updated
2021/12/16
TRC
Product number
A549508
Product name
AI-3
Packaging
2.5mg
Price
$275
Updated
2021/12/16
Usbiological
Product number
254570
Product name
AI-3
Packaging
10mg
Price
$452
Updated
2021/12/16
ApexBio Technology
Product number
B7761
Product name
AI-3
Packaging
10mg
Price
$308
Updated
2021/12/16
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1-Chloro-3-methanesulfonyl-6,6-dimethyl-6,7-dihydro-5H-benzo[c]thiophen-4-one Chemical Properties,Usage,Production

Description

AI-3 (882288-28-0) is an activator of antioxidant response element (ARE) which induces cytoprotective genes in human cells. It alkylates Keap1 at Cys151 and is reactive toward additional cysteines at higher concentrations. Disrupts Nrf2/Keap1 and Keap1/Cul3 interactions and stabilizes Nrf2. AI-3 activates ARE in an Nrf2 and PI 3-kinase dependent manner. Cell permeable and active?in vivo.

Uses

AI-3 is an electrophilic, antioxidant response element (ARE) activator. AI-3 has the potential to become a valuable biological tool regarding the development of therapeutics towards oxidative stress related diseases.

References

1) Wang?et al. (2013),?In vitro and in vivo characterization of a tunable dual-reactivity probe of the Nrf2-ARE pathway; ACS Chem. Biol.,?8?1764

1-Chloro-3-methanesulfonyl-6,6-dimethyl-6,7-dihydro-5H-benzo[c]thiophen-4-one Preparation Products And Raw materials

Raw materials

Preparation Products

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1-Chloro-3-methanesulfonyl-6,6-dimethyl-6,7-dihydro-5H-benzo[c]thiophen-4-one Suppliers

CHINA 14 India 1 United Kingdom 1 United States 6 USA 1 Global 23
MedBioPharmaceutical Technology Inc
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882288-28-0, 1-Chloro-3-methanesulfonyl-6,6-dimethyl-6,7-dihydro-5H-benzo[c]thiophen-4-oneRelated Search:

Hinokitiol Celastrol Xanthohumol zerumbone

  • 1-Chloro-3-methanesulfonyl-6,6-dimethyl-6,7-dihydro-5H-benzo[c]thiophen-4-one
  • 1-Chloro-6,7-dihydro-6,6-dimethyl-3-(methylsulfonyl)-benzo[c]thiophen-4(5H)-one
  • AI-3
  • Benzo[c]thiophen-4(5H)-one, 1-chloro-6,7-dihydro-6,6-dimethyl-3-(methylsulfonyl)-
  • AI 3,AI3
  • 882288-28-0
  • C11H13ClO3S2