1-Chloro-3-methanesulfonyl-6,6-dimethyl-6,7-dihydro-5H-benzo[c]thiophen-4-one
- Product Name
- 1-Chloro-3-methanesulfonyl-6,6-dimethyl-6,7-dihydro-5H-benzo[c]thiophen-4-one
- CAS No.
- 882288-28-0
- Chemical Name
- 1-Chloro-3-methanesulfonyl-6,6-dimethyl-6,7-dihydro-5H-benzo[c]thiophen-4-one
- Synonyms
- AI-3;AI 3,AI3;1-Chloro-3-methanesulfonyl-6,6-dimethyl-6,7-dihydro-5H-benzo[c]thiophen-4-one;1-Chloro-6,7-dihydro-6,6-dimethyl-3-(methylsulfonyl)-benzo[c]thiophen-4(5H)-one;Benzo[c]thiophen-4(5H)-one, 1-chloro-6,7-dihydro-6,6-dimethyl-3-(methylsulfonyl)-
- CBNumber
- CB43836091
- Molecular Formula
- C11H13ClO3S2
- Formula Weight
- 292.8
- MOL File
- 882288-28-0.mol
1-Chloro-3-methanesulfonyl-6,6-dimethyl-6,7-dihydro-5H-benzo[c]thiophen-4-one Property
- storage temp.
- -20°C
- solubility
- Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 25 mg/ml).
- form
- solid
- color
- White
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
N-Bromosuccinimide Price
- Product number
- 5145
- Product name
- AI-3
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $180
- Updated
- 2021/12/16
- Product number
- 5145
- Product name
- AI-3
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $749
- Updated
- 2021/12/16
- Product number
- 254570
- Product name
- AI-3
- Packaging
- 10mg
- Price
- $452
- Updated
- 2021/12/16
- Product number
- A549508
- Product name
- AI-3
- Packaging
- 2.5mg
- Price
- $275
- Updated
- 2021/12/16
- Product number
- B7761
- Product name
- AI-3
- Packaging
- 10mg
- Price
- $308
- Updated
- 2021/12/16
1-Chloro-3-methanesulfonyl-6,6-dimethyl-6,7-dihydro-5H-benzo[c]thiophen-4-one Chemical Properties,Usage,Production
Description
AI-3 (882288-28-0) is an activator of antioxidant response element (ARE) which induces cytoprotective genes in human cells. It alkylates Keap1 at Cys151 and is reactive toward additional cysteines at higher concentrations. Disrupts Nrf2/Keap1 and Keap1/Cul3 interactions and stabilizes Nrf2. AI-3 activates ARE in an Nrf2 and PI 3-kinase dependent manner. Cell permeable and active?in vivo.
Uses
AI-3 is an electrophilic, antioxidant response element (ARE) activator. AI-3 has the potential to become a valuable biological tool regarding the development of therapeutics towards oxidative stress related diseases.
References
1) Wang?et al. (2013),?In vitro and in vivo characterization of a tunable dual-reactivity probe of the Nrf2-ARE pathway; ACS Chem. Biol.,?8?1764