ChemicalBook > CAS DataBase List > 3-(2-Pyrrolidinyl)pyridine

3-(2-Pyrrolidinyl)pyridine

Product Name
3-(2-Pyrrolidinyl)pyridine
CAS No.
5746-86-1
Chemical Name
3-(2-Pyrrolidinyl)pyridine
Synonyms
DL-NORNICOTINE;(R,S)-NORNICOTINE;NORNICOTINE, DL-;(+/-)-NORNICOTINE;Nicotine USP RC F;(+/-)-nornicotine;DL-Nornicotine,96%;beta-dl-nornicotine;(+ -)-NORNICOTINE 98+%;Sertindole Impurity 20
CBNumber
CB4385206
Molecular Formula
C9H12N2
Formula Weight
148.21
MOL File
5746-86-1.mol
More
Less

3-(2-Pyrrolidinyl)pyridine Property

Melting point:
235-236 °C(Solv: ethanol (64-17-5))
Boiling point:
107-108°C 2mm
Density 
1,074 g/cm3
refractive index 
1.54
Flash point:
101°C
storage temp. 
2-8°C
solubility 
H2O: 50 mg/mL
form 
liquid
pka
9.09±0.10(Predicted)
Specific Gravity
1.074
color 
yellow
Water Solubility 
Soluble in acetone, chloroform and water (50mg/ml).
Merck 
14,6712
BRN 
81968
Stability:
Hygroscopic, Light Sensitive, Moisture Sensitive
CAS DataBase Reference
5746-86-1(CAS DataBase Reference)
More
Less

Safety

Hazard Codes 
Xn,Xi,T,F
Risk Statements 
20/21/22-36/37/38-39/23/24/25-23/24/25-11
Safety Statements 
26-36/37-45-16-7
RIDADR 
2810
WGK Germany 
3
RTECS 
QS6350000
F 
3-10
HazardClass 
6.1
PackingGroup 
III
HS Code 
29399990
Toxicity
LDLo ipr-rat: 6 mg/kg AJEBAK 25,83,47
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR3063
Product name
Nicotine Related Compound F
Purity
pharmaceutical secondary standard, certified reference material
Packaging
50MG
Price
$461
Updated
2024/03/01
Sigma-Aldrich
Product number
N-071
Product name
(±)-Nornicotine solution
Purity
1.0?mg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant?
Packaging
1mL
Price
$107
Updated
2024/03/01
Sigma-Aldrich
Product number
1463371
Product name
Nicotine Related Compound F
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
20mg
Price
$1380
Updated
2024/03/01
Alfa Aesar
Product number
L10809
Product name
DL-Nornicotine, 98%
Packaging
10mg
Price
$69.1
Updated
2021/12/16
Alfa Aesar
Product number
L10809
Product name
DL-Nornicotine, 98%
Packaging
50mg
Price
$225
Updated
2021/12/16
More
Less

3-(2-Pyrrolidinyl)pyridine Chemical Properties,Usage,Production

Description

(±)-Nornicotine is a metabolite of nicotine that acts as a neuronal nicotinic acetylcholine receptor (nAChR) agonist. The α6 and α7 subunit-containing neuronal nAChRs are particularly responsive to nornicotine with EC50 values of approximately 4 and 17 μM, respectively, when expressed in Xenopus oocytes. Nornicotine promotes cell migration and destabilizes cell-cell junctions in an endothelial cell line. It is generally thought to be free from abuse potential, but it has been self-administered by rats. It can be detected in urine.

Chemical Properties

Colourless Oil

Uses

A metabolite of Nicotine ((N412420). Can catalyze aqueous aldol reactions.

Uses

A metabolite of Nicotine. Can catalyze aqueous aldol reactions

Uses

3-(2-Pyrrolidinyl)pyridine is a tobacco alkaloid and the major Nicotine (N412420) metabolite in brain. Nornicotine appears to activate different nAChR subtypes, has a better pharmacokinetic profile, and produces less toxicity than Nicotine. Nornicotine shows a significant analgesic activity. Nicotine USP Related Compound F (3-(pyrrolidine-2-yl)pyridine).

Synthesis Reference(s)

Tetrahedron Letters, 37, p. 1137, 1996 DOI: 10.1016/0040-4039(96)00002-0

Safety Profile

Poison by intraperitoneal route.When heated to decomposition it emits very toxic fumesof NOx and HCl. See also NORNICOTINE

3-(2-Pyrrolidinyl)pyridine Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

3-(2-Pyrrolidinyl)pyridine Suppliers

Canada 1 China 133 Czech 1 France 2 Germany 4 Hungary 1 India 4 Russia 1 South Korea 1 Switzerland 1 Ukraine 1 United Kingdom 13 United States 37 Global 200
Shanghai ZaiQi Bio-Tech Co., Ltd.
Tel
021-54824098-8020 13817598959
Fax
021-54824069
Email
sales@chemzq.com
Country
China
ProdList
181
Advantage
55
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44689
Advantage
61
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Email
sales@capotchem.com
Country
China
ProdList
18207
Advantage
66
Beijing Ouhe Technology Co., Ltd
Tel
010-82967028 13552068683
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12390
Advantage
60
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
19172
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42958
Advantage
64
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11707
Advantage
57
Hangzhou Yuhao Chemical Technology Co., Ltd
Tel
0571-82693216
Fax
+86-571-82880190
Email
info@yuhaochemical.com
Country
China
ProdList
9387
Advantage
52
Sci General Material & Chemical Ltd
Tel
21-58388037 13472507714
Fax
0086-21-56829747 Company QQ: 1589045147
Email
1589045147@qq.com
Country
China
ProdList
729
Advantage
55
Shanghai ZaiQi Bio-Tech Co., Ltd.
Tel
021-54824098, 021-37212705 021-37212706, 13391256916
Fax
021-54824069
Email
sales@chemzq.com
Country
China
ProdList
570
Advantage
55
Shanghai Topbiochem Technology Co., Ltd
Tel
+86-21-60341587
Fax
+86-21-61294319
Email
sales@topbiochem.com
Country
China
ProdList
6175
Advantage
58
Shanghai T&W Pharmaceutical Co., Ltd.
Tel
+86 21 61551611
Fax
+86 21 50676805
Country
China
ProdList
9891
Advantage
58
Shanghai Jian Chao Chemical Technology Co., Ltd.
Tel
18017383231 18017383231
Fax
qq：2817624287
Email
lyh_antaeus@163.com
Country
China
ProdList
9347
Advantage
55
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-400-6206333 18521732826
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
The future of Shanghai Industrial Co., Ltd.
Tel
021-61552785
Fax
021-55660885
Email
sales@shshiji.com
Country
China
ProdList
9545
Advantage
55
Shanghai Tauto Biotech Co., Ltd.
Tel
021-51320588
Fax
0086-21-51320502
Email
tauto@tautobiotech.com
Country
China
ProdList
3989
Advantage
66
Amatek Scientific Co. Ltd.
Tel
0512-56316828 4008675858
Fax
+86-512-56316826
Email
sales@amateksci.com
Country
China
ProdList
9895
Advantage
55
Shanghai JONLN Reagent Co., Ltd.
Tel
400-0066400 13621662912
Fax
021-55660885
Email
422131432@qq.com
Country
China
ProdList
9978
Advantage
55
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
41462
Advantage
60
Shanghai Worldyang Chemical Co.,Ltd.
Tel
021-021-56795766
Fax
+86-21-56795266
Email
sales@worldyachem.com
Country
China
ProdList
9346
Advantage
58
Shanghai YuYuan Pharmaceutical Co., Ltd.
Tel
13052276172
Fax
13052276172
Email
product@yuyuanpharm.com
Country
China
ProdList
761
Advantage
55
Chengdu HuaXia Chemical Reagent Co. Ltd
Tel
400-1166-196 13458535857
Fax
QQ：800101999
Email
cdhxsj@163.com
Country
China
ProdList
13350
Advantage
58
Chemfun Medical Technology(Shanghai) Co., Ltd.
Tel
021-67220633 021-54824098
Fax
+86-21-54824069
Email
chemfun@chemfun.net
Country
China
ProdList
491
Advantage
58
Suzhou yacoo science co.,Ltd
Tel
0512-87182056 18013166090
Fax
0512-87182056
Email
lingling.qi@yacoo.com.cn
Country
China
ProdList
7295
Advantage
60
Shanghai Macklin Biochemical Co.,Ltd.
Tel
15221275939 15221275939
Fax
021-50706099
Email
shenlinxing@macklin.cn
Country
China
ProdList
16166
Advantage
55
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66113011 18112977050
Email
cb6@aikonchem.com
Country
China
ProdList
16684
Advantage
50
Shanghai Tombiopharma Chemical Co. Ltd.
Tel
13391076197
Email
tombiopharma@163.com
Country
China
ProdList
4987
Advantage
55
LABTER PHARMATECH(BEIJING) CO.,LTD
Tel
010-56330744 18310155299
Fax
010-56330744
Email
sales@labter.com.cn
Country
China
ProdList
23967
Advantage
55
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51456
Advantage
80
Struchem Co., Ltd.
Tel
0512-0512-63009836 15365350169
Fax
0512-63006936
Email
helen@struchem.com
Country
China
ProdList
3984
Advantage
60
SanoChem (Chengdu) Tech. Co., Ltd.
Tel
28-87999436 02887999436
Fax
QQ:2746983436
Email
sales@sano-chem.com
Country
China
ProdList
3795
Advantage
55
Shanghai Synchem Pharma Co., ltd
Tel
21-619849051-1 18521059765
Email
synchempharma@aliyun.com
Country
China
ProdList
6463
Advantage
55
NovoChemy Ltd.
Tel
86-(0)21-31261262 373522135
Fax
86-(0)21-33250524
Email
sales@novochemy.com
Country
China
ProdList
6498
Advantage
58
Chengdu jingzhihuacheng Chemical Technology Co., Ltd.
Tel
028-37664989 15900794981
Email
jingzhichem@163.com
Country
China
ProdList
888
Advantage
55
Zhengzhou Alfachem Co., Ltd.
Tel
0371-53765687 18937137882
Fax
QQ:2885373884
Email
2853979813@qq.com
Country
China
ProdList
7980
Advantage
55
Codow Chemical Co.,Ltd.
Tel
18620099427
Fax
+86-20-62619665
Email
amy@howeipharm.com
Country
China
ProdList
17687
Advantage
55
Henan CoreyChem Co., Ltd
Tel
0371-86658258
Fax
0371-60996044
Email
info@coreychem.com
Country
China
ProdList
10453
Advantage
58
Changzhou Hopschain Chemical Co.,Ltd.
Tel
0519-85528066 13775048983
Fax
0519-85528066
Email
sales@hopschem.com
Country
China
ProdList
31553
Advantage
55
parabiochem
Tel
025-83453382-8005
Fax
025-83453382
Email
sale@parabiochem.com
Country
China
ProdList
9595
Advantage
55
Shandong Xiya Chemical Co., Ltd.
Tel
4009903999 13395398332
Fax
0539-6365991
Email
sales@xiyashiji.com
Country
China
ProdList
20806
Advantage
60
Chengdu Dianchun Technology Co., Ltd
Tel
400-1166-196 18502815961
Fax
QQ：800101999
Email
cdhxsj@163.com
Country
China
ProdList
14603
Advantage
60
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973186 4009686088
Email
3193328036@qq.com
Country
China
ProdList
18338
Advantage
68
Hubei Yangxin Medical Technology Co., Ltd.
Tel
15374522761
Fax
QQ:2853117752
Email
3003392093@qq.com
Country
China
ProdList
8377
Advantage
55
Capot Chemical Co.,Ltd.
Tel
+86-（0）57185586718 +86-13336195806
Fax
+86-571-85864795
Email
sales@capot.com
Country
China
ProdList
29791
Advantage
60
SHANGHAI FDC-CHEMICAL CO.,LTD
Tel
021-61469567 13482353728
Fax
021-61161605
Email
sales@fdc-chemical.com
Country
China
ProdList
16474
Advantage
58
Bejing Famous Pharmaceutical Technology Co., Ltd.
Tel
13331045123
Fax
86-10-80339217
Email
1963319514@qq.com
Country
China
ProdList
14224
Advantage
58
More
Less

View Lastest Price from 3-(2-Pyrrolidinyl)pyridine manufacturers

Hebei Mojin Biotechnology Co.,Ltd
Product
3-(2-Pyrrolidinyl)pyridine 5746-86-1
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
50000KG/month
Release date
2024-08-07
Career Henan Chemical Co
Product
2-(3-Pyridyl)pyrrolidine, 3-(2-Pyrrolidinyl)pyridine;Nicotine, 1'-demethyl-, (+-)- 5746-86-1
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200kg
Release date
2019-12-30

5746-86-1, 3-(2-Pyrrolidinyl)pyridineRelated Search:

Pyridine Polyvinylpyrrolidone Pyrrolidine Povidone iodine N-Methyl-2-pyrrolidone N-Vinyl-2-pyrrolidone 3-(Pyrrolidin-2-yl)pyridine hydrochloride 3-(pyrrolidin-2-yl)pyridine dihydrochloride Nicotine (+/-)-COTININE-D3 (-)-COTININE (+/-)-NICOTINE-METHYL-D3 (+)-3-[(2R)-1-Methyl-2-pyrrolidinyl]pyridine,3-[(2R)-1-Methyl-2-pyrrolidinyl]pyridine (+/-)-COTININE-D3 NICOTINE DITARTRATE DIHYDRATE (S)-3-(1-METHYL-2-PYRROLIDINYL)PYRIDINE, DI-D-TARTRATE,(S)-3-(1-METHYL-2-PYRROLIDINYL)PYRIDINE TARTRATE SALT 4-(2-PYRROLIDINYL)PYRIDINE METHYL-2-PYRROLIDONE

  • NORNICOTINE, DL-
  • (+/-)-NORNICOTINE
  • (R,S)-NORNICOTINE
  • (+-)-1’-demethylnicotine
  • beta-dl-nornicotine
  • 3-PYRROLIDIN-2-YLPYRIDINE
  • DL-NORNICOTINE
  • 2-[3-PYRIDYL]PYRROLIDINE
  • 2-[3-PYRIDYL]PYRROLIDONE
  • (+/-)-3-(2-PYRROLIDINYL)PYRIDINE
  • 3-(2-PYRROLIDINYL)PYRIDINE
  • DL-2-(3-Pyridyl)pyrrolidine
  • (+ -)-NORNICOTINE 98+%
  • DL-Nornicotine,96%
  • 2-(3-Pyridyl)pyrrolidine, 3-(2-Pyrrolidinyl)pyridine
  • Nicotine, 1'-demethyl-, (+-)-
  • Pyridine, 3-(2-pyrrolidinyl)-, (+-)- (9ci)
  • (±)-Nornicotine,2-(3-Pyridyl)pyrrolidine, 3-(2-Pyrrolidinyl)pyridine
  • DL-Nornicotine/3-(Pyrrolidin-2-yl)pyridine
  • 2-(3-Pyridinyl)pyrrolidine
  • 2-(Pyridin-3-yl)pyrrolidine
  • (RS)-Nornicotine (1.0 Mg/ML in Methanol)
  • 3-(2-Pyrrolidyl)pyridine
  • (±)-Nornicotine solution
  • Pyridine, 3-(2-pyrrolidinyl)-
  • Nicotine Related Compound F
  • Nicotine USP Related Compound F (rac-Nicotine EP Impurity F)
  • Nicotine USP RC F
  • Nicotine Related Compound F (20 mg)
  • (2S)-2-(3-Pyridinyl)pyrrolidinium
  • (+/-)-nornicotine
  • (+/-)-Nornicotine, 3-(2-Pyrrolininyl)pyridine
  • Nicotine Impurity F as Racemate
  • 3-[(2S)-pyrrolidin-2-yl]pyridine (nornicotine)
  • Nicotine EP Impurity F as Racemate
  • Sertindole Impurity 20
  • rac-Nicotine EP Impurity F
  • (+ -)-NORNICOTINE 98+%
  • (+-)-1’-demethylnicotine
  • 5746-86-1
  • AMINE
  • BioChemical
  • Cell Biology
  • Cell Signaling and Neuroscience
  • Ion Channels
  • Ligand-Gated Ion Channels
  • Nicotinic Acetylcholine Receptor Modulators
  • Metabolites & Impurities
  • Aromatics
  • Chiral Reagents
  • Heterocycles
  • Mutagenesis Research Chemicals
  • pharmacetical
  • Nicotine Derivatives
  • Benzenes
  • Heterocycle-Pyridine series
  • Alkaloids