3-(2-Pyrrolidinyl)pyridine
- Product Name
- 3-(2-Pyrrolidinyl)pyridine
- CAS No.
- 5746-86-1
- Chemical Name
- 3-(2-Pyrrolidinyl)pyridine
- Synonyms
- DL-NORNICOTINE;(R,S)-NORNICOTINE;NORNICOTINE, DL-;(+/-)-NORNICOTINE;Nicotine USP RC F;(+/-)-nornicotine;DL-Nornicotine,96%;beta-dl-nornicotine;(+ -)-NORNICOTINE 98+%;Sertindole Impurity 20
- CBNumber
- CB4385206
- Molecular Formula
- C9H12N2
- Formula Weight
- 148.21
- MOL File
- 5746-86-1.mol
3-(2-Pyrrolidinyl)pyridine Property
- Melting point:
- 235-236 °C(Solv: ethanol (64-17-5))
- Boiling point:
- 107-108°C 2mm
- Density
- 1,074 g/cm3
- refractive index
- 1.54
- Flash point:
- 101°C
- storage temp.
- 2-8°C
- solubility
- H2O: 50 mg/mL
- form
- liquid
- pka
- 9.09±0.10(Predicted)
- Specific Gravity
- 1.074
- color
- yellow
- Water Solubility
- Soluble in acetone, chloroform and water (50mg/ml).
- Merck
- 14,6712
- BRN
- 81968
- Stability:
- Hygroscopic, Light Sensitive, Moisture Sensitive
- CAS DataBase Reference
- 5746-86-1(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn,Xi,T,F
- Risk Statements
- 20/21/22-36/37/38-39/23/24/25-23/24/25-11
- Safety Statements
- 26-36/37-45-16-7
- RIDADR
- 2810
- WGK Germany
- 3
- RTECS
- QS6350000
- F
- 3-10
- HazardClass
- 6.1
- PackingGroup
- III
- HS Code
- 29399990
- Toxicity
- LDLo ipr-rat: 6 mg/kg AJEBAK 25,83,47
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- PHR3063
- Product name
- Nicotine Related Compound F
- Purity
- pharmaceutical secondary standard, certified reference material
- Packaging
- 50MG
- Price
- $461
- Updated
- 2024/03/01
- Product number
- N-071
- Product name
- (±)-Nornicotine solution
- Purity
- 1.0?mg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant?
- Packaging
- 1mL
- Price
- $107
- Updated
- 2024/03/01
- Product number
- 1463371
- Product name
- Nicotine Related Compound F
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 20mg
- Price
- $1380
- Updated
- 2024/03/01
- Product number
- L10809
- Product name
- DL-Nornicotine, 98%
- Packaging
- 10mg
- Price
- $69.1
- Updated
- 2021/12/16
- Product number
- L10809
- Product name
- DL-Nornicotine, 98%
- Packaging
- 50mg
- Price
- $225
- Updated
- 2021/12/16
3-(2-Pyrrolidinyl)pyridine Chemical Properties,Usage,Production
Description
(±)-Nornicotine is a metabolite of nicotine that acts as a neuronal nicotinic acetylcholine receptor (nAChR) agonist. The α6 and α7 subunit-containing neuronal nAChRs are particularly responsive to nornicotine with EC50 values of approximately 4 and 17 μM, respectively, when expressed in Xenopus oocytes. Nornicotine promotes cell migration and destabilizes cell-cell junctions in an endothelial cell line. It is generally thought to be free from abuse potential, but it has been self-administered by rats. It can be detected in urine.
Chemical Properties
Colourless Oil
Uses
A metabolite of Nicotine ((N412420). Can catalyze aqueous aldol reactions.
Uses
A metabolite of Nicotine. Can catalyze aqueous aldol reactions
Uses
3-(2-Pyrrolidinyl)pyridine is a tobacco alkaloid and the major Nicotine (N412420) metabolite in brain. Nornicotine appears to activate different nAChR subtypes, has a better pharmacokinetic profile, and produces less toxicity than Nicotine. Nornicotine shows a significant analgesic activity. Nicotine USP Related Compound F (3-(pyrrolidine-2-yl)pyridine).
Synthesis Reference(s)
Tetrahedron Letters, 37, p. 1137, 1996 DOI: 10.1016/0040-4039(96)00002-0
Safety Profile
Poison by intraperitoneal route.When heated to decomposition it emits very toxic fumesof NOx and HCl. See also NORNICOTINE
3-(2-Pyrrolidinyl)pyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-(2-Pyrrolidinyl)pyridine manufacturers
- Product
- 3-(2-Pyrrolidinyl)pyridine 5746-86-1
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2024-08-07
- Product
- 2-(3-Pyridyl)pyrrolidine, 3-(2-Pyrrolidinyl)pyridine;Nicotine, 1'-demethyl-, (+-)- 5746-86-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2019-12-30