ARANIDIPINE

Product Name: ARANIDIPINE
CAS No.: 86780-90-7
Chemical Name: ARANIDIPINE
Synonyms: Sapresta;MPC-1304;ARANIDIPINE;Asanidipine;Aranidipine MPC1304;ARANIDIPINE USP/EP/BP;ARANIDIPINE MPC1304;MPC-1304;MPC 1304;Calcium Channel,inhibit,MPC 1304,Inhibitor,MPC-1304,Aranidipine,Ca channels,Ca2+ channels;3-Methyl 5-(2-oxopropyl) 2,6-diMethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate;2，6-Dimethyl-4-(2-nitrophenyl)-1，4-dihydro-3，5-pyridinedicarboxylic acid methyl 2-oxopropyl ester
CBNumber: CB4386708
Molecular Formula: C19H20N2O7
Formula Weight: 388.37
MOL File: 86780-90-7.mol

More

Less

ARANIDIPINE Property

Melting point:: 155°
Boiling point:: 530.0±50.0 °C(Predicted)
Density: 1.284±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO : 125 mg/mL (321.86 mM)
form: Solid
pka: 2.56±0.70(Predicted)
color: Light yellow to yellow

More

Less

Safety

Toxicity: LD50 in male, female mice, rats (mg/kg): 143, 193, 1982, 1459 orally; LD50 in male, female mice (mg/kg): 7.3, 9.1 i.p. (Nakano)

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P501Dispose of contents/container to..…

More

Less

N-Bromosuccinimide Price

ChemScene

Product number: CS-7341
Product name: Aranidipine
Purity: 99.33%
Packaging: 5mg
Price: $60
Updated: 2021/12/16

ChemScene

Product number: CS-7341
Product name: Aranidipine
Purity: 99.33%
Packaging: 10mg
Price: $105
Updated: 2021/12/16

ChemScene

Product number: CS-7341
Product name: Aranidipine
Purity: 99.33%
Packaging: 50mg
Price: $315
Updated: 2021/12/16

ChemScene

Product number: CS-7341
Product name: Aranidipine
Purity: 99.33%
Packaging: 100mg
Price: $535
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb573449
Product name: Aranidipine (MPC1304)
Purity: >98%
Packaging: 100mg
Price: $986
Updated: 2021/12/16

More

Less

ARANIDIPINE Chemical Properties,Usage,Production

Description

Aranidipine was launched in Japan as an antihypertensive agent. Its pharmacological effects are similar to other dihydropyridine derivatives, e.g., nefidipine, however, it is more potent and longer lasting. This is partially due to the fact that its initial metabolite (ketone reduction) is just as effective as the parent compound. Aranidipine exerts its activity by blocking Ca⁺² entry during depolarization via L-type voltagegated Ca channels. This causes decreased levels of intracellular Ca which leads to enhanced relaxation of smooth and cardiac muscle. It is a selective α₂-adrenoreceptor antagonist which inhibits vasoconstrictive responses. As a dihydropyridine derivative, it can be synthesized via a modified Hantsch synthesis. While sold as a racemate, the (S)-enantiomer is 150 times more active than the (R)- antipode.

Originator

Maruko Seiyaku (Japan)

Definition

ChEBI: Aranidipine is an organic molecular entity.

Manufacturing Process

100.0 mg of 50% sodium hydride was added to a mixture of 20.0 g of 2,2- ethylenedioxypropanol and 100 ml of benzene, and 20.0 g of diketene was added dropwise to the mixture while refluxing the mixture. After refluxing the mixture for 2 h, the solvent was distilled off and the resulting residue was distilled under reduced pressure to obtain 21.5 g (70% yield) of 2,2- ethylenedioxypropyl acetoacetate as a colorless oil, boiling point of 90°C (6 mm Hg).
Ammonia gas was passed through a mixture of 19.0 g of 2,2- ethylenedioxypropyl acetoacetate and 100 ml of methanol for 2.5 h under icecooling while stirring. The solvent was then distilled off and the residue was distilled under reduced pressure to obtain 16.0 g (84% yield) of 2,2- ethylenedioxypropyl 3-aminocrotonate as a pale yellow oil, boiling point of 120°C (5 mm Hg).
A mixture of methyl 2'-nitrobenzylidene acetoacetate, 2,2-ethylenedioxypropyl 3-aminocrotonate and ethanol was refluxed for 10 h. The resulting reaction solution was allowed to stand overnight, and the precipitated crystals were collected by filtration and recrystallized from ethanol to obtain methyl 2,2- ethylenedioxypropyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5- dicarboxylate.
Methyl 2,2-ethylenedioxypropyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4- dihydropyridine-3,5-dicarboxylate was refluxed in an ethanol solution containing 10% hydrochloric acid for 6 h. The solvent was then distilled off and the residue was crystallized from diethyl ether to give methyl 2-oxopropyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate as yellow prisms, melting point 155°C (recrystallized from a mixture of ethyl acetate and hexane).

brand name

Bec/Sapresta

Therapeutic Function

Antihypertensive

ARANIDIPINE Preparation Products And Raw materials

Raw materials

Crotonic acid

Preparation Products

More

Less

ARANIDIPINE Suppliers

China 46 Europe 2 Germany 2 United Kingdom 2 United States 19 Global 71

LGM Pharma

Tel: 1-(800)-881-8210
Fax: 615-250-9817
Email: inquiries@lgmpharma.com
Country: United States
ProdList: 2123
Advantage: 70

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32161
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
Advantage: 58

TargetMol Chemicals Inc.

Tel
Email: support@targetmol.com
Country: United States
ProdList: 38631
Advantage: 58

MedChemExpress

Tel: --
Fax: --
Email: sales@medchemexpress.com
Country: United States
ProdList: 6398
Advantage: 58

Alfa Chemistry

Tel: --
Fax: --
Email: info@Alfa-Chemistry.com
Country: United States
ProdList: 6814
Advantage: 0

BOSCHE SCIENTIFIC, LLC

Tel: --
Fax: --
Email: Sales@BoscheSci.com
Country: United States
ProdList: 6477
Advantage: 55

Amfinecom Inc.

Tel: --
Fax: --
Email: sales@amfinecom.com
Country: United States
ProdList: 3062
Advantage: 50

OChem Incorporation

Tel: --
Fax: --
Email: sales@ocheminc.com
Country: United States
ProdList: 6501
Advantage: 60

Atlantic SciTech Group, Inc.

Tel: --
Fax: --
Email: sales@astginc.com
Country: United States
ProdList: 2308
Advantage: 43

AlliChem, LLC

Tel: --
Fax: --
Email: sales@allichemllc.com
Country: United States
ProdList: 6516
Advantage: 60

Waterstone Technology, LLC

Tel: --
Fax: --
Email: sales@waterstonetech.com
Country: United States
ProdList: 6786
Advantage: 30

2A PharmaChem USA

Tel: --
Fax: --
Email: sales@2apharmachem.com
Country: United States
ProdList: 6137
Advantage: 39

3B Scientific Corporation

Tel: --
Fax: --
Email: sales@3bsc.com
Country: United States
ProdList: 6718
Advantage: 47

AK Scientific, Inc.

Tel: --
Fax: --
Email: sales@aksci.com
Country: United States
ProdList: 6347
Advantage: 65

APAC Pharmaceutical, LLC

Tel: --
Fax: --
Email: sales@apacpharma.com
Country: United States
ProdList: 6322
Advantage: 38

ChemPacific Corporation

Tel: --
Fax: --
Email: sales@chempacific.com
Country: United States
ProdList: 6891
Advantage: 51

Beta Pharma, Inc.

Tel: --
Fax: --
Email: sales@betapharma.com
Country: United States
ProdList: 6226
Advantage: 60

More

Less

View Lastest Price from ARANIDIPINE manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Aranidipine 86780-90-7
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 500 MT
Release date: 2020-05-11

86780-90-7, ARANIDIPINERelated Search:

Lercanidipine hydrochloride Rofecoxib Amlodipine Entacapone Azelnidipine Lacidipine 3-(2-NITRO-PHENYL)-PROPAN-1-OL Nifedipine 3-(2-NITRO-PHENYL)-PROPIONIC ACID ETHYL ESTER 1-SEC-BUTYL-2-NITROBENZENE ARANIDIPINE

ARANIDIPINE

2，6-Dimethyl-4-(2-nitrophenyl)-1，4-dihydro-3，5-pyridinedicarboxylic acid methyl 2-oxopropyl ester

MPC-1304

Sapresta

1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-methyl 5-(2-oxopropyl) ester

Asanidipine

3,5-Pyridinedicarboxylicacid, 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-, 3-methyl 5-(2-oxopropyl)ester

3-Methyl 5-(2-oxopropyl) 2,6-diMethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Aranidipine MPC1304

ARANIDIPINE MPC1304;MPC-1304;MPC 1304

ARANIDIPINE USP/EP/BP

Calcium Channel,inhibit,MPC 1304,Inhibitor,MPC-1304,Aranidipine,Ca channels,Ca2+ channels

86780-90-7