Lacidipine

Product Name: Lacidipine
CAS No.: 103890-78-4
Chemical Name: Lacidipine
Synonyms: β-GPA;MOTENS;SN-305;LACIPIL;LACIREX;GX-1048;CALDINE;Lacidipin;GR-43659X;LACIDIPINE
CBNumber: CB5296310
Molecular Formula: C26H33NO6
Formula Weight: 455.54
MOL File: 103890-78-4.mol

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Lacidipine Property

Melting point:: 174-175°C
Boiling point:: 558.4±50.0 °C(Predicted)
Density: 1.127±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: soluble20mg/mL, clear
form: powder
pka: 3.00±0.70(Predicted)
color: white to beige
Merck: 14,5331
InChIKey: GKQPCPXONLDCMU-CCEZHUSRSA-N
CAS DataBase Reference: 103890-78-4(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 22
WGK Germany: 3
RTECS: US7970200
Toxicity: mouse,LD50,intraperitoneal,80200ug/kg (80.2mg/kg),SKIN AND APPENDAGES (SKIN): HAIR: OTHERSENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYEBEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY),Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 22, Pg. 335, 1994.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0946
Product name: Lacidipine
Purity: ≥98% (HPLC)
Packaging: 10mg
Price: $88.8
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0946
Product name: Lacidipine
Purity: ≥98% (HPLC)
Packaging: 50mg
Price: $286
Updated: 2024/03/01

TCI Chemical

Product number: L0276
Product name: Lacidipine
Purity: >98.0%(HPLC)(N)
Packaging: 1g
Price: $480
Updated: 2023/01/07

TCI Chemical

Product number: L0276
Product name: Lacidipine
Purity: >98.0%(HPLC)(N)
Packaging: 200mg
Price: $146
Updated: 2021/12/16

Cayman Chemical

Product number: 28270
Product name: Lacidipine
Packaging: 100mg
Price: $97
Updated: 2024/03/01

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Lacidipine Chemical Properties,Usage,Production

Description

Lacidipine is a new second-generation dihydropyridine calcium antagonist introduced as a once a day treatment for mild to moderate hypertension. It is reported to have high selectivity for vascular smooth muscle and also a long duration of action. The use of lacidipine as an antiatherosclerotic agent is currently under investigation.

Description

Lacidipine is a dihydropyridine L-type calcium channel blocker. It induces relaxation of isolated rat aorta and inhibits calcium-induced contraction of rabbit ear artery (pA₂ = 9.4). It also induces relaxation of calcium-induced contractions in isolated rat colon and bladder and guinea pig trachea (IC₅₀s = 6.7, 6, and 7.8 nM, respectively). Lacidipine induces negative inotropy in isolated guinea pig ventricular strips (IC₅₀ = 110 nM). It reduces mean blood pressure in spontaneously hypertensive rats (ED₂₅ = 0.35 mg/kg) and in renal hypertensive dogs (ED₂₅ = 0.22 mg/kg) with a transient increase in heart rate. Lacidipine inhibits copper-induced oxidation of isolated human LDL when used at concentrations of 1 and 5 μM. It reduces the extension of aortic atheromatous lesions and decreases renal injury in ApoE^-/- mice in a model of Western diet-induced atherosclerosis.

Chemical Properties

White-to-Off-White Crystalline Solid

Originator

Glaxo (United Kingdom)

Uses

A dihydropyridine calcium channel blocker. Antihypertensive.

Uses

antihypertensive;dihydropyridinr calcium channel blocker

Definition

ChEBI: Lacidipine is a cinnamate ester and a tert-butyl ester.

brand name

Lacipil; Lacirex; Viapres

Biochem/physiol Actions

Lacidipine is a long-acting calcium antagonist that is used in the management of hypertension. Lacidipine is a L-type Ca(2+) channel blocker belonging to 1,4-dihydropyridine class. Also, Lacidipine inhibits ryanodine receptors on the ER membrane that enhances folding, trafficking and lysosomal activity of ERAD (ER-associated degradation) misfolded lysosomal glucocerebrosidase (GS).

Lacidipine Preparation Products And Raw materials

Raw materials

tert-Butyl acetate Ethyl crotonate o-Phthalaldehyde trans-Cinnamic acid Triphenylphosphine tert-Butyl acrylate

Preparation Products

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Lacidipine Suppliers

Americas 1 Belgium 1 Brazil 1 Canada 6 China 239 Europe 3 France 1 Germany 2 India 34 Italy 1 Japan 1 Nepal 1 South Korea 4 Spain 2 Turkey 1 United Arab Emirates 1 United Kingdom 13 United States 42 Global 354

Hubei Yuanmeng Biotechnology Co., Ltd

Tel: 027-68897569 18120462897
Fax: 027-68897569
Email: fiona@yuanmengbio.com
Country: China
ProdList: 432
Advantage: 58

Jiangxi ravel Biotechnology Co.,Ltd

Tel: 185-0276-2003 18502762003;
Email: 435918333@qq.com
Country: China
ProdList: 2243
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15848
Advantage: 69

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24539
Advantage: 81

BeiJing Hwrk Chemicals Limted

Tel: 0757-86329057 18501085097
Fax: 010-89508210
Email: sales3.gd@hwrkchemical.com
Country: China
ProdList: 7583
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Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44751
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Pure Chemistry Scientific Inc.

Tel: 001-857-928-2050 or 1-888-588-9418
Fax: 001-617-206-9595
Email: sales@chemreagents.com
Country: United States
ProdList: 10194
Advantage: 62

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: zhangsn@titansci.com
Country: China
ProdList: 14113
Advantage: 59

LGM Pharma

Tel: 1-(800)-881-8210
Fax: 615-250-9817
Email: inquiries@lgmpharma.com
Country: United States
ProdList: 2127
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View Lastest Price from Lacidipine manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Lacidipine 103890-78-4
Price: US $0.00/G
Min. Order: 10G
Purity: 98%min
Supply Ability: 30kg/month
Release date: 2023-02-08

Henan Bao Enluo International TradeCo.，LTD

Product: Lacidipine 103890-78-4
Price: US $120.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000tons
Release date: 2023-08-09

Hebei Mojin Biotechnology Co., Ltd

Product: Lacidipine 103890-78-4
Price: US $100.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 5000kg/week
Release date: 2021-06-10

103890-78-4, LacidipineRelated Search:

Phenyl salicylate Ethoxyquin DIETHOXYMETHANE Diphenyl ether PHENYL VALERATE Fentin hydroxide Ethoxyamine hydrochloride PHENYL RESIN Phenylacetic acid Oxygen cis Lacidipine trans Lacidipine-d10,LACIDIPINE-D10 Dehydro Lacidipine 2,6-DIMETHYL-3,5-PYRIDINEDICARBOXYLIC ACID Lacidipine LACIDIPINE INTERMEDIATE:4-(2-BROMOPHENYL)-1,4-DIHYDRO-2,6-DIMETHYL-3,5-PYRIDINEDICARBOXYLIC ACID DIETHYL ESTER 4-(2-bromophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid diethyl ester (intermediate of lacidipine) LACIDIPINE IMPURITY STANDARD

3,5-pyridinedicarboxylicacid,1,4-dihydro-2,6-dimethyl-4-(2-(3-(1,1-dimethylet

diethylester,(e)-hoxy)-3-oxo-1-propenyl)phenyl)

MOTENS

3,5-Diethyl 4-{2-[(1E)-3-(tert-butoxy)-3-oxoprop-1-en-1-yl]phenyl}-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

CID 5311217

Lacidipine，Lacipil

Lacidipine Solution, 100ppm

4-[2-[(1E)-3-(1,1-dimethylethoxy)-3-oxo-1-propen-1-yl]phenyl]-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid 3,5-diethyl ester

GX-1048,GR-43659X,SN-305

Lacidipine Solution, 1000ppm

LACIPIL;MOTENS

LACIPIL

LACIREX

LACIDIPINE

LACIDIPINE-D9

Lacidipin

LACIDIPINE, IMPURITY STANDARD BP STANDARD

LACIDIPINE, BP STANDARD

LACIDIPINE ASSAY STANDARD BP(CRM STANDARD)

LACIDIPINE BP STANDARD(CRM STANDARD)

LACIDIPINE IMPURITY STANDARD BP STANDARD(CRM STANDARD)

LACIDIPINE IMPURITY STANDARD BP(CRM STANDARD)

LacidipineC26H33N06

GX-1048

GR-43659X

CALDINE

(E)-4-[2-[3-(1,1-DIMETHYLETHOXY)-3-OXO-1-PROPENYL]PHENYL]-1,4-DIHYDRO-2,6-DIMETHYL-3,5-PYRIDINEDICARBOXYLIC ACID DIETHYL ESTER

(E)-4-[2-[3-(1,1-Dimethylethoxy)-3-oxo-1-propenyl]phenyl]-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic Acid Diethyl Ester, GR-43659X, GX-1048, Caldine, Lacipil, Lacirex, Motens

trans Lacidipine

Lacidipine (Lacipil, Motens)

3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(2-(3-(1,1-dimethylethoxy)-3-oxo-1- propenyl)phenyl)-, diethyl ester, (E)-

Diethyl 2,6-dimethyl-4-[2-[(E)-3-[(2-methylpropan-2-yl)oxy]-3-oxoprop-1-enyl]phenyl]-1,4-dihydropyridine-3,5-dicarboxylate

4-[2-[(1E)-3-(1,1-Dimethylethoxy)-3-oxo-1-propenyl]phenyl]-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid diethyl ester

4-[2-[(E)-3-(1,1-Dimethylethoxy)-3-oxo-1-propenyl]phenyl]-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid diethyl ester

SN-305

2,6-dimethyl-4-[2-[(E)-3-[(2-methylpropan-2-yl)oxy]-3-oxoprop-1-enyl]phenyl]-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester

3,5-Pyridinedicarboxylic acid, 4-[2-[(1E)-3-(1,1-dimethylethoxy)-3-oxo-1-propen-1-yl]phenyl]-1,4-dihydro-2,6-dimethyl-, 3,5-diethyl ester

Lacidipine USP/EP/BP

(E)-Diethyl 4-(2-(3-(tert-butoxy)-3-oxoprop-1-en-1-yl)phenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

Lacidipine (GX-1048, GR-43659X, SN-305, Lacipil, Motens)

LacidipineQ: What is Lacidipine Q: What is the CAS Number of Lacidipine Q: What is the storage condition of Lacidipine Q: What are the applications of Lacidipine

β-GPA

Lacidipine flat

Lacipil, Motens, Lacidipine

iethyl2,6-dimethyl-4-[2-[(E)-3-[(2-methylpropan-2-yl)oxy]-3-oxoprop-1-enyl]phenyl]-1,4-dihydropyridine-3,5-dicarboxylate

Lacidipine Diethyl 4-{o-[(E)-2-tert-butoxycarbonylethenyl]phenyl}-2,6- dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

103890-78-4

C26H33NO6

C26H24NO6D9

Calcium channel

Dihydropyridine

Intermediates & Fine Chemicals

Pharmaceuticals

Active Pharmaceutical Ingredients

Dihydropyridine Class Chemicals

API

Lacipil, Motens