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Lacidipine

Product Name
Lacidipine
CAS No.
103890-78-4
Chemical Name
Lacidipine
Synonyms
β-GPA;MOTENS;SN-305;LACIPIL;LACIREX;GX-1048;CALDINE;Lacidipin;GR-43659X;LACIDIPINE
CBNumber
CB5296310
Molecular Formula
C26H33NO6
Formula Weight
455.54
MOL File
103890-78-4.mol
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Lacidipine Property

Melting point:
174-175°C
Boiling point:
558.4±50.0 °C(Predicted)
Density 
1.127±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: soluble20mg/mL, clear
form 
powder
pka
3.00±0.70(Predicted)
color 
white to beige
Merck 
14,5331
InChIKey
GKQPCPXONLDCMU-CCEZHUSRSA-N
CAS DataBase Reference
103890-78-4(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
22
WGK Germany 
3
RTECS 
US7970200
Toxicity
mouse,LD50,intraperitoneal,80200ug/kg (80.2mg/kg),SKIN AND APPENDAGES (SKIN): HAIR: OTHERSENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYEBEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY),Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 22, Pg. 335, 1994.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0946
Product name
Lacidipine
Purity
≥98% (HPLC)
Packaging
10mg
Price
$88.8
Updated
2024/03/01
Sigma-Aldrich
Product number
SML0946
Product name
Lacidipine
Purity
≥98% (HPLC)
Packaging
50mg
Price
$286
Updated
2024/03/01
TCI Chemical
Product number
L0276
Product name
Lacidipine
Purity
>98.0%(HPLC)(N)
Packaging
1g
Price
$480
Updated
2023/01/07
TCI Chemical
Product number
L0276
Product name
Lacidipine
Purity
>98.0%(HPLC)(N)
Packaging
200mg
Price
$146
Updated
2021/12/16
Cayman Chemical
Product number
28270
Product name
Lacidipine
Packaging
100mg
Price
$97
Updated
2024/03/01
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Lacidipine Chemical Properties,Usage,Production

Description

Lacidipine is a new second-generation dihydropyridine calcium antagonist introduced as a once a day treatment for mild to moderate hypertension. It is reported to have high selectivity for vascular smooth muscle and also a long duration of action. The use of lacidipine as an antiatherosclerotic agent is currently under investigation.

Description

Lacidipine is a dihydropyridine L-type calcium channel blocker. It induces relaxation of isolated rat aorta and inhibits calcium-induced contraction of rabbit ear artery (pA2 = 9.4). It also induces relaxation of calcium-induced contractions in isolated rat colon and bladder and guinea pig trachea (IC50s = 6.7, 6, and 7.8 nM, respectively). Lacidipine induces negative inotropy in isolated guinea pig ventricular strips (IC50 = 110 nM). It reduces mean blood pressure in spontaneously hypertensive rats (ED25 = 0.35 mg/kg) and in renal hypertensive dogs (ED25 = 0.22 mg/kg) with a transient increase in heart rate. Lacidipine inhibits copper-induced oxidation of isolated human LDL when used at concentrations of 1 and 5 μM. It reduces the extension of aortic atheromatous lesions and decreases renal injury in ApoE-/- mice in a model of Western diet-induced atherosclerosis.

Chemical Properties

White-to-Off-White Crystalline Solid

Originator

Glaxo (United Kingdom)

Uses

A dihydropyridine calcium channel blocker. Antihypertensive.

Uses

antihypertensive;dihydropyridinr calcium channel blocker

Definition

ChEBI: Lacidipine is a cinnamate ester and a tert-butyl ester.

brand name

Lacipil; Lacirex; Viapres

Biochem/physiol Actions

Lacidipine is a long-acting calcium antagonist that is used in the management of hypertension. Lacidipine is a L-type Ca(2+) channel blocker belonging to 1,4-dihydropyridine class. Also, Lacidipine inhibits ryanodine receptors on the ER membrane that enhances folding, trafficking and lysosomal activity of ERAD (ER-associated degradation) misfolded lysosomal glucocerebrosidase (GS).

Lacidipine Preparation Products And Raw materials

Raw materials

tert-Butyl acetate Ethyl crotonate o-Phthalaldehyde trans-Cinnamic acid Triphenylphosphine tert-Butyl acrylate

Preparation Products

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Lacidipine Suppliers

Americas 1 Belgium 1 Brazil 1 Canada 6 China 240 Europe 3 France 1 Germany 2 India 34 Italy 1 Japan 1 Nepal 1 South Korea 4 Spain 2 Turkey 1 United Arab Emirates 1 United Kingdom 13 United States 42 Global 355
TOKYO CHEMICAL INDUSTRY CO., LTD.
Tel
03-36680489
Fax
03-3668-0520
Email
Sales-JP@TCIchemicals.com
Country
Japan
ProdList
28398
Advantage
80
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View Lastest Price from Lacidipine manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Lacidipine 103890-78-4
Price
US $0.00/G
Min. Order
10G
Purity
98%min
Supply Ability
30kg/month
Release date
2023-02-08
Henan Bao Enluo International TradeCo.，LTD
Product
Lacidipine 103890-78-4
Price
US $120.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000tons
Release date
2023-08-09
Hebei Mojin Biotechnology Co., Ltd
Product
Lacidipine 103890-78-4
Price
US $100.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
5000kg/week
Release date
2021-06-10

103890-78-4, LacidipineRelated Search:

Phenyl salicylate Ethoxyquin DIETHOXYMETHANE Diphenyl ether PHENYL VALERATE Fentin hydroxide Ethoxyamine hydrochloride PHENYL RESIN Phenylacetic acid Oxygen cis Lacidipine trans Lacidipine-d10,LACIDIPINE-D10 Dehydro Lacidipine 2,6-DIMETHYL-3,5-PYRIDINEDICARBOXYLIC ACID Lacidipine LACIDIPINE INTERMEDIATE:4-(2-BROMOPHENYL)-1,4-DIHYDRO-2,6-DIMETHYL-3,5-PYRIDINEDICARBOXYLIC ACID DIETHYL ESTER 4-(2-bromophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid diethyl ester (intermediate of lacidipine) LACIDIPINE IMPURITY STANDARD

  • 3,5-pyridinedicarboxylicacid,1,4-dihydro-2,6-dimethyl-4-(2-(3-(1,1-dimethylet
  • diethylester,(e)-hoxy)-3-oxo-1-propenyl)phenyl)
  • MOTENS
  • 3,5-Diethyl 4-{2-[(1E)-3-(tert-butoxy)-3-oxoprop-1-en-1-yl]phenyl}-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
  • CID 5311217
  • Lacidipine，Lacipil
  • Lacidipine Solution, 100ppm
  • 4-[2-[(1E)-3-(1,1-dimethylethoxy)-3-oxo-1-propen-1-yl]phenyl]-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid 3,5-diethyl ester
  • GX-1048,GR-43659X,SN-305
  • Lacidipine Solution, 1000ppm
  • LACIPIL;MOTENS
  • LACIPIL
  • LACIREX
  • LACIDIPINE
  • LACIDIPINE-D9
  • Lacidipin
  • LACIDIPINE, IMPURITY STANDARD BP STANDARD
  • LACIDIPINE, BP STANDARD
  • LACIDIPINE ASSAY STANDARD BP(CRM STANDARD)
  • LACIDIPINE BP STANDARD(CRM STANDARD)
  • LACIDIPINE IMPURITY STANDARD BP STANDARD(CRM STANDARD)
  • LACIDIPINE IMPURITY STANDARD BP(CRM STANDARD)
  • LacidipineC26H33N06
  • GX-1048
  • GR-43659X
  • CALDINE
  • (E)-4-[2-[3-(1,1-DIMETHYLETHOXY)-3-OXO-1-PROPENYL]PHENYL]-1,4-DIHYDRO-2,6-DIMETHYL-3,5-PYRIDINEDICARBOXYLIC ACID DIETHYL ESTER
  • (E)-4-[2-[3-(1,1-Dimethylethoxy)-3-oxo-1-propenyl]phenyl]-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic Acid Diethyl Ester, GR-43659X, GX-1048, Caldine, Lacipil, Lacirex, Motens
  • trans Lacidipine
  • Lacidipine (Lacipil, Motens)
  • 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(2-(3-(1,1-dimethylethoxy)-3-oxo-1- propenyl)phenyl)-, diethyl ester, (E)-
  • Diethyl 2,6-dimethyl-4-[2-[(E)-3-[(2-methylpropan-2-yl)oxy]-3-oxoprop-1-enyl]phenyl]-1,4-dihydropyridine-3,5-dicarboxylate
  • 4-[2-[(1E)-3-(1,1-Dimethylethoxy)-3-oxo-1-propenyl]phenyl]-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid diethyl ester
  • 4-[2-[(E)-3-(1,1-Dimethylethoxy)-3-oxo-1-propenyl]phenyl]-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid diethyl ester
  • SN-305
  • 2,6-dimethyl-4-[2-[(E)-3-[(2-methylpropan-2-yl)oxy]-3-oxoprop-1-enyl]phenyl]-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester
  • 3,5-Pyridinedicarboxylic acid, 4-[2-[(1E)-3-(1,1-dimethylethoxy)-3-oxo-1-propen-1-yl]phenyl]-1,4-dihydro-2,6-dimethyl-, 3,5-diethyl ester
  • Lacidipine USP/EP/BP
  • (E)-Diethyl 4-(2-(3-(tert-butoxy)-3-oxoprop-1-en-1-yl)phenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
  • Lacidipine (GX-1048, GR-43659X, SN-305, Lacipil, Motens)
  • LacidipineQ: What is Lacidipine Q: What is the CAS Number of Lacidipine Q: What is the storage condition of Lacidipine Q: What are the applications of Lacidipine
  • β-GPA
  • Lacidipine flat
  • Lacipil, Motens, Lacidipine
  • iethyl2,6-dimethyl-4-[2-[(E)-3-[(2-methylpropan-2-yl)oxy]-3-oxoprop-1-enyl]phenyl]-1,4-dihydropyridine-3,5-dicarboxylate
  • Lacidipine Diethyl 4-{o-[(E)-2-tert-butoxycarbonylethenyl]phenyl}-2,6- dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
  • 103890-78-4
  • C26H33NO6
  • C26H24NO6D9
  • Calcium channel
  • Dihydropyridine
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Active Pharmaceutical Ingredients
  • Dihydropyridine Class Chemicals
  • API
  • Lacipil, Motens