CGP 35348

Product Name: CGP 35348
CAS No.: 123690-79-9
Chemical Name: CGP 35348
Synonyms: CGP 35348;CGP 35348 hydrate;(3-AMINOPROPYL)(DIETHOXYMETHYL)PHOSPHINIC ACID;Phosphinic acid, (3-aminopropyl)(diethoxymethyl)-;P-(3-Aminopropyl)-P-(diethoxymethyl)phosphinic acid;Phosphinic acid, P-(3-aminopropyl)-P-(diethoxymethyl)-;(3-Aminopropyl)(diethoxymethyl)phosphinic acid hydrate;spatial learning,neuromuscular,neonatal damage,CGP-35348,brain penetrant,GABA Receptor,CGP35348,Gamma-aminobutyric acid Receptor,centrally,GABAB,CGP 35348,Inhibitor,γ-Aminobutyric acid Receptor,inhibit,active
CBNumber: CB4386728
Molecular Formula: C8H20NO4P
Formula Weight: 225.22
MOL File: 123690-79-9.mol

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CGP 35348 Property

storage temp.: −20°C
solubility: H₂O: >10 mg/mL
form: solid
color: white
Water Solubility: Soluble in water (100mM)

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C5851
Product name: CGP 35348 hydrate
Purity: ≥97% (NMR), solid
Packaging: 5mg
Price: $206
Updated: 2024/03/01

Sigma-Aldrich

Product number: C5851
Product name: CGP 35348 hydrate
Purity: ≥97% (NMR), solid
Packaging: 25mg
Price: $700
Updated: 2024/03/01

Cayman Chemical

Product number: 18599
Product name: CGP 35348
Purity: ≥95%
Packaging: 10mg
Price: $166
Updated: 2024/03/01

Cayman Chemical

Product number: 18599
Product name: CGP 35348
Purity: ≥95%
Packaging: 50mg
Price: $739
Updated: 2024/03/01

Tocris

Product number: 1245
Product name: CGP35348
Packaging: 50
Price: $818
Updated: 2021/12/16

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CGP 35348 Chemical Properties,Usage,Production

Uses

CGP 35348 hydrate has been used as a γ-aminobutyric acid-B (GABA_B) receptor inhibitor:

to study its effects on intrinsic optical signal (IOS) in rat hippocampus
alone or in combination with sodium salicylate to study its effects on auditory responses in the rat′s dorsal cortex of rat
to study its effects on hepatocellular carcinoma cells (HCC)

Biological Activity

Selective, brain penetrant GABA B receptor antagonist (IC 50 = 34 μ M as measured in rat cortical membranes). Has higher affinity for postsynaptic versus presynaptic receptors.

Biochem/physiol Actions

CGP 35348 is a γ-aminobutyric acid-B (GABAB) receptor antagonist. It has a higher affinity towards post-versus presynaptic receptors that can penetrate the blood-brain barrier.

storage

Room temperature

References

[1]. olpe hr, karlsson g, pozza mf, et al. cgp 35348: a centrally active blocker of gabab receptors. eur j pharmacol, 1990, 187(1): 27-38.
[2]. hammond dl, washington jd. antagonism of l-baclofen-induced antinociception by cgp 35348 in the spinal cord of the rat. eur j pharmacol, 1993, 234(2-3): 255-262.
[3]. hao jx, xu xj, wiesenfeld-hallin z. intrathecal gamma-aminobutyric acidb (gabab) receptor antagonist cgp 35348 induces hypersensitivity to mechanical stimuli in the rat. neurosci lett, 1994, 182(2): 299-302.
[4]. patel sm, ebenezer is. the effects of intraperitoneal and intracerebroventricular administration of the gabab receptor antagonist cgp 35348 on food intake in rats. eur j pharmacol, 2004, 503(1-3): 89-93.

CGP 35348 Preparation Products And Raw materials

Raw materials

Preparation Products

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CGP 35348 Suppliers

China 24 Germany 2 Japan 1 Switzerland 1 United Kingdom 3 United States 7 USA 1 Global 39

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15839
Advantage: 69

Ascent Scientific

Tel: 4401179829988
Fax: 4402030 700 369
Email: customerservice@ascentscientific.co.uk
Country: United Kingdom
ProdList: 279
Advantage: 60

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51456
Advantage: 80

EMMX Biotechnology LLC

Tel: 888-539-0666
Fax: 888-539-0666
Email: info@emmx.com
Country: United States
ProdList: 8447
Advantage: 60

Tianjin Kailiqi Biotechnology Co., Ltd.

Tel: 15076683720
Fax: 022-23754520
Email: klq@cw-bio.com
Country: China
ProdList: 4554
Advantage: 55

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32063
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11217
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing1@energy-chemical.com
Country: China
ProdList: 44808
Advantage: 58

MedBioPharmaceutical Technology Inc

Tel: 021-69568360 18916172912
Email: order@med-bio.cn
Country: China
ProdList: 8140
Advantage: 58

Shanghai Universal Biotech Co.,Ltd

Tel: 13774214275
Email: gaojun@univ-bio.com
Country: China
ProdList: 24990
Advantage: 58

123690-79-9, CGP 35348Related Search:

Hydroxypropyl methyl cellulose Hypophosphorous acid ethylmethylphosphinic acid CGP 35348 CGP 52432 3-AMINOPROPYL(METHYL)PHOSPHINIC ACID HCL

CGP 35348

(3-AMINOPROPYL)(DIETHOXYMETHYL)PHOSPHINIC ACID

(3-Aminopropyl)(diethoxymethyl)phosphinic acid hydrate

CGP 35348 hydrate

P-(3-Aminopropyl)-P-(diethoxymethyl)phosphinic acid

Phosphinic acid, (3-aminopropyl)(diethoxymethyl)-

spatial learning,neuromuscular,neonatal damage,CGP-35348,brain penetrant,GABA Receptor,CGP35348,Gamma-aminobutyric acid Receptor,centrally,GABAB,CGP 35348,Inhibitor,γ-Aminobutyric acid Receptor,inhibit,active

Phosphinic acid, P-(3-aminopropyl)-P-(diethoxymethyl)-

123690-79-9

C8H20NO4P

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