CGP 35348
- Product Name
- CGP 35348
- CAS No.
- 123690-79-9
- Chemical Name
- CGP 35348
- Synonyms
- CGP 35348;CGP 35348 hydrate;(3-AMINOPROPYL)(DIETHOXYMETHYL)PHOSPHINIC ACID;Phosphinic acid, (3-aminopropyl)(diethoxymethyl)-;P-(3-Aminopropyl)-P-(diethoxymethyl)phosphinic acid;Phosphinic acid, P-(3-aminopropyl)-P-(diethoxymethyl)-;(3-Aminopropyl)(diethoxymethyl)phosphinic acid hydrate;spatial learning,neuromuscular,neonatal damage,CGP-35348,brain penetrant,GABA Receptor,CGP35348,Gamma-aminobutyric acid Receptor,centrally,GABAB,CGP 35348,Inhibitor,γ-Aminobutyric acid Receptor,inhibit,active
- CBNumber
- CB4386728
- Molecular Formula
- C8H20NO4P
- Formula Weight
- 225.22
- MOL File
- 123690-79-9.mol
CGP 35348 Property
- storage temp.
- −20°C
- solubility
- H2O: >10 mg/mL
- form
- solid
- color
- white
- Water Solubility
- Soluble in water (100mM)
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- C5851
- Product name
- CGP 35348 hydrate
- Purity
- ≥97% (NMR), solid
- Packaging
- 5mg
- Price
- $206
- Updated
- 2024/03/01
- Product number
- C5851
- Product name
- CGP 35348 hydrate
- Purity
- ≥97% (NMR), solid
- Packaging
- 25mg
- Price
- $700
- Updated
- 2024/03/01
- Product number
- 18599
- Product name
- CGP 35348
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $166
- Updated
- 2024/03/01
- Product number
- 18599
- Product name
- CGP 35348
- Purity
- ≥95%
- Packaging
- 50mg
- Price
- $739
- Updated
- 2024/03/01
- Product number
- 1245
- Product name
- CGP35348
- Packaging
- 50
- Price
- $818
- Updated
- 2021/12/16
CGP 35348 Chemical Properties,Usage,Production
Uses
CGP 35348 hydrate has been used as a γ-aminobutyric acid-B (GABAB) receptor inhibitor:
- to study its effects on intrinsic optical signal (IOS) in rat hippocampus
- alone or in combination with sodium salicylate to study its effects on auditory responses in the rat′s dorsal cortex of rat
- to study its effects on hepatocellular carcinoma cells (HCC)
Biological Activity
Selective, brain penetrant GABA B receptor antagonist (IC 50 = 34 μ M as measured in rat cortical membranes). Has higher affinity for postsynaptic versus presynaptic receptors.
Biochem/physiol Actions
CGP 35348 is a γ-aminobutyric acid-B (GABAB) receptor antagonist. It has a higher affinity towards post-versus presynaptic receptors that can penetrate the blood-brain barrier.
storage
Room temperature
References
[1]. olpe hr, karlsson g, pozza mf, et al. cgp 35348: a centrally active blocker of gabab receptors. eur j pharmacol, 1990, 187(1): 27-38.
[2]. hammond dl, washington jd. antagonism of l-baclofen-induced antinociception by cgp 35348 in the spinal cord of the rat. eur j pharmacol, 1993, 234(2-3): 255-262.
[3]. hao jx, xu xj, wiesenfeld-hallin z. intrathecal gamma-aminobutyric acidb (gabab) receptor antagonist cgp 35348 induces hypersensitivity to mechanical stimuli in the rat. neurosci lett, 1994, 182(2): 299-302.
[4]. patel sm, ebenezer is. the effects of intraperitoneal and intracerebroventricular administration of the gabab receptor antagonist cgp 35348 on food intake in rats. eur j pharmacol, 2004, 503(1-3): 89-93.