ChemicalBook > CAS DataBase List > CGP 35348

CGP 35348

Product Name
CGP 35348
CAS No.
123690-79-9
Chemical Name
CGP 35348
Synonyms
C P 35348;CGP 35348;CGP 35348 hydrate;(3-AMINOPROPYL)(DIETHOXYMETHYL)PHOSPHINIC ACID;Phosphinic acid, (3-aminopropyl)(diethoxymethyl)-;P-(3-Aminopropyl)-P-(diethoxymethyl)phosphinic acid;Phosphinic acid, P-(3-aminopropyl)-P-(diethoxymethyl)-;(3-Aminopropyl)(diethoxymethyl)phosphinic acid hydrate;spatial learning,neuromuscular,neonatal damage,CGP-35348,brain penetrant,GABA Receptor,CGP35348,Gamma-aminobutyric acid Receptor,centrally,GABAB,CGP 35348,Inhibitor,γ-Aminobutyric acid Receptor,inhibit,active
CBNumber
CB4386728
Molecular Formula
C8H20NO4P
Formula Weight
225.22
MOL File
123690-79-9.mol
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CGP 35348 Property

storage temp. 
−20°C
solubility 
H2O: >10 mg/mL
form 
solid
color 
white
Water Solubility 
Soluble in water (100mM)
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C5851
Product name
CGP 35348 hydrate
Purity
≥97% (NMR), solid
Packaging
5mg
Price
$206
Updated
2024/03/01
Sigma-Aldrich
Product number
C5851
Product name
CGP 35348 hydrate
Purity
≥97% (NMR), solid
Packaging
25mg
Price
$700
Updated
2024/03/01
Cayman Chemical
Product number
18599
Product name
CGP 35348
Purity
≥95%
Packaging
10mg
Price
$166
Updated
2024/03/01
Cayman Chemical
Product number
18599
Product name
CGP 35348
Purity
≥95%
Packaging
50mg
Price
$739
Updated
2024/03/01
Tocris
Product number
1245
Product name
CGP35348
Packaging
50
Price
$818
Updated
2021/12/16
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CGP 35348 Chemical Properties,Usage,Production

Uses

CGP 35348 hydrate has been used as a γ-aminobutyric acid-B (GABAB) receptor inhibitor:

  • to study its effects on intrinsic optical signal (IOS) in rat hippocampus
  • alone or in combination with sodium salicylate to study its effects on auditory responses in the rat′s dorsal cortex of rat
  • to study its effects on hepatocellular carcinoma cells (HCC)

Biological Activity

Selective, brain penetrant GABA B receptor antagonist (IC 50 = 34 μ M as measured in rat cortical membranes). Has higher affinity for postsynaptic versus presynaptic receptors.

Biochem/physiol Actions

CGP 35348 is a γ-aminobutyric acid-B (GABAB) receptor antagonist. It has a higher affinity towards post-versus presynaptic receptors that can penetrate the blood-brain barrier.

storage

Room temperature

References

[1]. olpe hr, karlsson g, pozza mf, et al. cgp 35348: a centrally active blocker of gabab receptors. eur j pharmacol, 1990, 187(1): 27-38.
[2]. hammond dl, washington jd. antagonism of l-baclofen-induced antinociception by cgp 35348 in the spinal cord of the rat. eur j pharmacol, 1993, 234(2-3): 255-262.
[3]. hao jx, xu xj, wiesenfeld-hallin z. intrathecal gamma-aminobutyric acidb (gabab) receptor antagonist cgp 35348 induces hypersensitivity to mechanical stimuli in the rat. neurosci lett, 1994, 182(2): 299-302.
[4]. patel sm, ebenezer is. the effects of intraperitoneal and intracerebroventricular administration of the gabab receptor antagonist cgp 35348 on food intake in rats. eur j pharmacol, 2004, 503(1-3): 89-93.

CGP 35348 Preparation Products And Raw materials

Raw materials

Preparation Products

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CGP 35348 Suppliers

China 26 Germany 2 Japan 1 Switzerland 1 United Kingdom 3 United States 7 USA 1 Global 41
3B Pharmachem (Wuhan) International Co.,Ltd.
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Sigma-Aldrich
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Energy Chemical
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123690-79-9, CGP 35348Related Search:

Hydroxypropyl methyl cellulose Hypophosphorous acid ethylmethylphosphinic acid CGP 35348 CGP 52432 3-AMINOPROPYL(METHYL)PHOSPHINIC ACID HCL

  • CGP 35348
  • (3-AMINOPROPYL)(DIETHOXYMETHYL)PHOSPHINIC ACID
  • (3-Aminopropyl)(diethoxymethyl)phosphinic acid hydrate
  • CGP 35348 hydrate
  • P-(3-Aminopropyl)-P-(diethoxymethyl)phosphinic acid
  • Phosphinic acid, (3-aminopropyl)(diethoxymethyl)-
  • spatial learning,neuromuscular,neonatal damage,CGP-35348,brain penetrant,GABA Receptor,CGP35348,Gamma-aminobutyric acid Receptor,centrally,GABAB,CGP 35348,Inhibitor,γ-Aminobutyric acid Receptor,inhibit,active
  • Phosphinic acid, P-(3-aminopropyl)-P-(diethoxymethyl)-
  • C P 35348
  • 123690-79-9
  • C8H20NO4P
  • GABA/Glycine receptor
  • GABA