(E)-2-((1,4-dimethylpiperazin-2-ylidene)-amino)-5-nitro-N-phenylbenzamide(WXC09160)
- Product Name
- (E)-2-((1,4-dimethylpiperazin-2-ylidene)-amino)-5-nitro-N-phenylbenzamide(WXC09160)
- CAS No.
- 1613465-33-0
- Chemical Name
- (E)-2-((1,4-dimethylpiperazin-2-ylidene)-amino)-5-nitro-N-phenylbenzamide(WXC09160)
- Synonyms
- ML-336;2-[(1,4-Dimethylpiperazin-2-ylidene)amino]-5-nitro-N-phenylbenzamide;(E)-2-((1,4-dimethylpiperazin-2-ylidene)-amino)-5-nitro-N-phenylbenzamide;Benzamide, 2-[(E)-(1,4-dimethyl-2-piperazinylidene)amino]-5-nitro-N-phenyl-;B355252 2-[(1,4-Dimethylpiperazin-2-ylidene) amino]-5-nitro-N-phenylbenzamide;(E)-2-((1,4-dimethylpiperazin-2-ylidene)-amino)-5-nitro-N-phenylbenzamide(WXC09160);ML 336,VEEV V3526 CPE,inhibit,VEEV TC-83 CPE,ML-336,ML336,Virus Protease,VEEV,VEEV Wild Type CPE,venezuelan equine encephalitis virus,Inhibitor
- CBNumber
- CB43910320
- Molecular Formula
- C19H21N5O3
- Formula Weight
- 367.4
- MOL File
- 1613465-33-0.mol
(E)-2-((1,4-dimethylpiperazin-2-ylidene)-amino)-5-nitro-N-phenylbenzamide(WXC09160) Property
- Density
- 1.29±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- ≤0.2mg/ml in ethanol;10mg/ml in DMSO;20mg/ml in dimethyl formamide
- form
- crystalline solid
- pka
- 12.30±0.70(Predicted)
- color
- Off-white to yellow
N-Bromosuccinimide Price
- Product number
- 9001920
- Product name
- ML-336
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $49
- Updated
- 2024/03/01
- Product number
- 9001920
- Product name
- ML-336
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $227
- Updated
- 2024/03/01
- Product number
- 9001920
- Product name
- ML-336
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $333
- Updated
- 2024/03/01
- Product number
- 9001920
- Product name
- ML-336
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $770
- Updated
- 2024/03/01
- Product number
- C3581
- Product name
- ML-336
- Packaging
- 25mg
- Price
- $879
- Updated
- 2021/12/16
(E)-2-((1,4-dimethylpiperazin-2-ylidene)-amino)-5-nitro-N-phenylbenzamide(WXC09160) Chemical Properties,Usage,Production
Biological Activity
ml-336 is an inhibitor for veev-induced cytopathic effect.alphaviruses like venezuelan equine encephalitis virus (veev) are positive-sense, enveloped, single stranded rna viruses that are widely geographically distributed. veevs are found to be arthropod-borne viruses that are known to cause arthritis, encephalitis, rash, as well as death in humans.
in vitro
ml336 was identified as a first-in-class probe that inhibited a veev-induced cytopathic effect in three strains of the virus, which were v3526, tc-83, and trinidad donkey, in the low nanomolar range without having cytotoxicity (> 50 μm, selectivity index > 1500). in addition, ml336 could reduce viral titer (more than 7.2 log) dramatically below a 1 μm drug concentration. furthermore, ml336 showed a favorable in vitro pk profile that included moderate blood-brain barrier permeability. more importantly, ml336 seemed to be able to target the veev [1].
IC 50
32, 20, and 41 nm for tc-83, v3526, and trinidad donkey strains, respectively.
References
[1] chung d et al. ml336: development of quinazolinone-based inhibitors against venezuelan equine encephalitis virus (veev). probe reports from the nih molecular libraries program. bethesda (md): national center for biotechnology information (us); 2010-2012 dec 17.
(E)-2-((1,4-dimethylpiperazin-2-ylidene)-amino)-5-nitro-N-phenylbenzamide(WXC09160) Preparation Products And Raw materials
Raw materials
Preparation Products
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