Glycyl-glycyl-glycine Property

Melting point:

240-250 °C

Boiling point:

324.41°C (rough estimate)

Density 

1.4204 (rough estimate)

refractive index 

1.5250 (estimate)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

H₂O: 0.5 M at 20 °C, clear, colorless

pka

3.225(at 25℃)

form 

Solid

color 

White to Off-White

PH

4.5-6.0 (25℃, 0.5M in H2O)

Water Solubility 

Soluble in water (94.6 mg/ml at 20°C), methanol (50 mg/ml), and 80% acetic acid (50 mg/ml).

λmax

λ: 260 nm Amax: 0.15
λ: 280 nm Amax: 0.10

Merck 

14,6579

BRN 

1711130

InChIKey

XKUKSGPZAADMRA-UHFFFAOYSA-N

CAS DataBase Reference

556-33-2(CAS DataBase Reference)

NIST Chemistry Reference

N-(N-Glycylglycyl)glycine(556-33-2)

Safety

WGK Germany 

3

F 

3-10

HS Code 

29241990

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

Glycyl-glycyl-glycine Chemical Properties,Usage,Production

Chemical Properties

White prismatic crystals or powder cannot coexist with strong oxidizing agents, aluminum, copper, copper alloy, and nickel. Glycyl-glycyl-glycine has a strong complexing ability and can form stable chelates with different metal ions due to its small molecule size and ability to provide four coordination bonds for metal ions.

Uses

Glycyl-glycyl-glycine is used as a model peptide for studies of physicochemical parameters and molecular associations of small peptides. It is also used as a copper chelator and Substrate for tripeptide aminopeptidase.

Application

Glycyl-glycyl-glycine is commonly used in the food, pharmaceutical, and cosmetic industries as an ingredient in skin and hair care products. It is also used as a dietary supplement due to its ability to improve digestion and promote the growth of healthy gut bacteria.

Definition

ChEBI: Glycyl-glycyl-glycine is a tripeptide in which three glycine units are linked via peptide bonds in a linear sequence. It is a tautomer of a Gly-Gly-Gly zwitterion.

General Description

Gly-Gly-Gly or triglycine is a flexible peptide linker with three glycine residues linked by peptide bonds in a linear sequence. Gly-linkers link multiple domains in a single protein without affecting the function of each domain.

Biochem/physiol Actions

Substrate for reproducible serum protein measurements by the biuret reaction and for the assay of aminotripeptidases.

Purification Methods

Crystallise triglycine from H2O or H2O/EtOH and dry it at 110o. [Yakel & Hughes Acta Cryst 5 847 1952, Lenel et al. Acta Cryst 3 313 1952, Holley & Holley J Am Chem Soc 74 3072 1952, Beilstein 4 III 1198, 4 IV 2469.]