ChemicalBook > CAS DataBase List > (S)-N-BOC-Propargylglycine

(S)-N-BOC-Propargylglycine

Product Name
(S)-N-BOC-Propargylglycine
CAS No.
63039-48-5
Chemical Name
(S)-N-BOC-Propargylglycine
Synonyms
Boc-Pra-OH;BOC-L-PROPARGYLGLYCINE;RARECHEM BK PT 0256;Boc-propargyl-Gly-OH;Boc-Propargylglycine;Boc-Gly(propargyl)-OH;N-Boc-L-propargylglycine;Boc-propargyl-Gly-OH, 95%;(S)-N-BOC-PROPARGYLGLYCINE;Nα-Boc-propargyl-L-glycine
CBNumber
CB4393184
Molecular Formula
C10H15NO4
Formula Weight
213.23
MOL File
63039-48-5.mol
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(S)-N-BOC-Propargylglycine Property

Melting point:
85.5 °C
Boiling point:
353.22°C (rough estimate)
Density 
1.2177 (rough estimate)
refractive index 
1.4368 (estimate)
storage temp. 
-20°C
pka
3.53±0.10(Predicted)
form 
Crystalline Powder
color 
Off-white to light yellow
optical activity
[α]/D 26.0±2.0°, c = 1 in methanol
Water Solubility 
Soluble in water.
BRN 
5739897
InChI
InChI=1S/C10H15NO4/c1-5-6-7(8(12)13)11-9(14)15-10(2,3)4/h1,7H,6H2,2-4H3,(H,11,14)(H,12,13)/t7-/m0/s1
InChIKey
AMKHAJIFPHJYMH-ZETCQYMHSA-N
SMILES
C(O)(=O)[C@@H](NC(OC(C)(C)C)=O)CC#C
CAS DataBase Reference
63039-48-5(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
24/25
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29241990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H317May cause an allergic skin reaction

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
712221
Product name
Boc-propargyl-Gly-OH
Purity
≥98.0% (HPLC)
Packaging
500mg
Price
$215
Updated
2025/07/31
TCI Chemical
Product number
B4007
Product name
N-(tert-Butoxycarbonyl)-L-propargylglycine
Purity
>97.0%(HPLC)(T)
Packaging
1g
Price
$97
Updated
2025/07/31
TRC
Product number
B663895
Product name
Boc-​L-​Propargylglycine
Packaging
2.5g
Price
$150
Updated
2021/12/16
TRC
Product number
B663895
Product name
Boc-​L-​Propargylglycine
Packaging
1g
Price
$75
Updated
2021/12/16
TRC
Product number
B663895
Product name
Boc-​L-​Propargylglycine
Packaging
250mg
Price
$45
Updated
2021/12/16
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(S)-N-BOC-Propargylglycine Chemical Properties,Usage,Production

Chemical Properties

off-white to light yellow crystalline powder

Uses

N-Boc-2-propargyl-L-glycine is used as pharmaceutical intermediate.

reaction suitability

reaction type: Boc solid-phase peptide synthesis
reaction type: click chemistry

Synthesis

24424-99-5

23235-01-0

61172-66-5

Step 5: Synthesis of Boc-L-ynylglycine L-alkynylglycine (10 g) [prepared according to Schwyzer et al. Helv. Chim. Acta, 59, 2181 (1976)] was suspended in tetrahydrofuran (30 mL). To this suspension, water (30 mL), potassium carbonate (36.7 g) and di-tert-butyl dicarbonate (21.9 g) were added sequentially. Subsequently, additional water was added to completely dissolve the mixture and the reaction mixture was stirred at room temperature for 12 hours. Upon completion of the reaction, the organic solvent was removed by evaporation. The resulting aqueous solution was first washed with ether and then acidified with aqueous 1N citric acid to pH 3. The acidified solution was extracted with dichloromethane, and the extract was evaporated to remove the solvent to afford Boc-L-alkynylglycine (18.9 g, 97% yield), which was used in subsequent steps without further purification.

References

[1] Chemistry - An Asian Journal, 2010, vol. 5, # 8, p. 1765 - 1769
[2] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 24, p. 7512 - 7515
[3] Patent: US5212185, 1993, A
[4] Patent: US5298505, 1994, A
[5] Patent: US5373017, 1994, A

(S)-N-BOC-Propargylglycine Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-N-BOC-Propargylglycine Suppliers

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View Lastest Price from (S)-N-BOC-Propargylglycine manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd
Product
Boc-propargyl-Gly-OH 63039-48-5
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1T
Release date
2023-11-16
Henan Aochuang Chemical Co.,Ltd.
Product
(S)-N-BOC-Propargylglycine 63039-48-5
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2022-10-19
Career Henan Chemical Co
Product
(S)-N-BOC-Propargylglycine 63039-48-5
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
200kg
Release date
2018-12-24

63039-48-5, (S)-N-BOC-PropargylglycineRelated Search:

L-Propargylglycine (R)-N-BOC-PROPARGYLGLYCINE,(R)-N-boc-Propargylglycine(e.e.),(R)-N-BOC-PROPARGYLGLYCINE, 95%, 98% EE,(R)-N-BOC-Propargylglycine, 98% ee (R)-METHYL-2-BOC-AMINO-4-PENTENOIC ACID D-PROPARGYLGLYCINE METHYL-2-BOC-AMINO-4-PENTENOIC ACID DL-PROPARGYLGLYCINE Boc-L-cyclopropylglycine CBZ-ALPHA-ALLYL-L-GLY D-Allylglycine CBZ-ALPHA-ALLYL-D-GLY (S)-2-(((benzyloxy)carbonyl)aMino)pent-4-ynoic acid (R)-2-(((benzyloxy)carbonyl)aMino)pent-4-ynoic acid 4-PENTYNOIC ACID Cyclohexylamine Glycine (S)-N-BOC-Propargylglycine BOC-L-PROPARGYLGLYCINE DCHA SALT BOC-(S)-ALPHA-PROPYNYL-PROLINE

  • BOC-L-PROPARGYLGLYCINE
  • (S)-N-(TERT-BUTOXYCARBONYL)-PROPARGYLGLYCINE
  • (S)-N-TERT-BUTOXYCARBONYL-2-AMINO-4-PENTYNOIC ACID
  • (S)-N-BOC-PROPARGYLGLYCINE
  • RARECHEM BK PT 0256
  • Boc-Gly(propargyl)-OH
  • (S)-N-Boc-propargylglycine(e.e.)
  • L-TERT-BUTOXYCARBONYL-L-PROPARGYL GLYCINE
  • BOC-2-PROPARGYL-L-GLYCINOL
  • N-BOC-2-PROPARGYL-L-GLYCINE
  • L-2-Propargylglycine, N-BOC protected
  • (S)-(1-Hydroxymethyl-but-3-ynyl)-carbamic acid tert-butyl ester
  • (S)-2-tert-Butoxycarbonylamino-pent-4-ynoic acid
  • Boc-Pra-OH
  • (2S)-2-(tert-butoxycarbonylamino)pent-4-ynoate
  • Boc-L-Propargylglycine.DCHA
  • (S)-N-Boc-propargylglycine, 95%, ee:98%
  • (S)-N-BOC-Propargylglycine, 98% ee
  • 2-Propargyl-L-glycine, N-BOC protected 97%
  • SYNONYMS (S)-N-BOC-PROPARGYLGLYCINE
  • (2S)-2-[[(2-methylpropan-2-yl)oxy-oxomethyl]amino]-4-pentynoate
  • (Tert-Butoxy)Carbonyl Pra-OH
  • (S)-N-BOC-Propargylglycine,95%,98% ee
  • (S)-N-BOC-Propargylglycine(S)-N-tert-Butoxycarbonyl-2-amino-4-pentynoic acid
  • Boc-propargyl-Gly-OH
  • (2S)-2-[(tert-Butoxycarbonyl)amino]pent-4-ynoic acid
  • 2-Propargyl-L-glycine, N-BOC protected
  • Boc-L-Propargylglycine Boc-L-Propargylglycine
  • Boc-Propargyl-Gly-OH, (S)-2-(Boc-aMino)-4-pentynoic acid
  • Nα-Boc-propargyl-L-glycine
  • (S)-2-Boc-AMino-4-pentynoic acid
  • N-(tert-Butoxycarbonyl)-L-propargylglycine
  • Boc-(S)-2-Propargylglycine
  • Boc-propargyl-Gly-OH >=98.0% (HPLC)
  • N-(tert-Butoxycarbonyl)-L-propargylglycine &gt
  • N-tert-Butoxycarbonyl-L-2-propargylglycine
  • Boc-Pra-OH Boc-Propargylglycine
  • 4-Pentynoic acid, 2-[[(1,1-dimethylethoxy)carbonyl]amino]-, (2S)-
  • (S)-2-(tert-Butoxycarbonylamino)-4-pentynoic Acid
  • N-Boc-L-propargylglycine
  • (S)-N-BOC-Propargylglycine USP/EP/BP
  • Boc-Propargylglycine
  • Boc-L-propargylglycine?DCHA - 1 g
  • Boc-propargyl-Gly-OH, 95%
  • 63039-48-5
  • C10H14NO4
  • Unusual amino acids
  • Amino Acid Derivatives
  • Amino Acids