L-Isoserine

Product Name: L-Isoserine
CAS No.: 632-13-3
Chemical Name: L-Isoserine
Synonyms: L-ISOSERINE;(S)-LSOSERINE;(S)-ISOSERINE;L-Isoserine>L-Isoserine USP/EP/BP;(S)-2-HYDROXY-B-ALANINE;(s)-2-hydroxy-β-alanine;Terbutaline Impurity 60;(-)-3-Amino-L-lactic acid;(S)-2-HYDROXY-BETA-ALANINE
CBNumber: CB4394257
Molecular Formula: C3H7NO3
Formula Weight: 105.09
MOL File: 632-13-3.mol

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L-Isoserine Property

Melting point:: 199~201℃
Boiling point:: 386.6±27.0 °C(Predicted)
Density: 1.415±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: powder to crystal
pka: pK1:2.72(＋1);pK2:9.25(0) (25°C,μ=0.16)
color: White to Almost white
Water Solubility: Slightly soluble in water.
Sensitive: Moisture Sensitive
InChI: InChI=1S/C3H7NO3/c4-1-2(5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1
InChIKey: BMYNFMYTOJXKLE-REOHCLBHSA-N
SMILES: C(O)(=O)[C@@H](O)CN
CAS DataBase Reference: 632-13-3(CAS DataBase Reference)

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Safety

WGK Germany: 3
F: 10-21
HS Code: 2922500090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 06054
Product name: L-Isoserine
Purity: ≥98.0% (TLC)
Packaging: 1G-F
Price: $155
Updated: 2023/06/20

Sigma-Aldrich

Product number: 06054
Product name: L-Isoserine
Purity: ≥98.0% (TLC)
Packaging: 1g
Price: $155
Updated: 2023/01/07

TCI Chemical

Product number: I0828
Product name: L-Isoserine
Purity: >98.0%(T)
Packaging: 1g
Price: $22
Updated: 2024/03/01

TCI Chemical

Product number: I0828
Product name: L-Isoserine
Purity: >98.0%(T)
Packaging: 5g
Price: $41
Updated: 2024/03/01

Alfa Aesar

Product number: H60945
Product name: L-Isoserine, 98%
Packaging: 250mg
Price: $63.65
Updated: 2024/03/01

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L-Isoserine Chemical Properties,Usage,Production

Uses

It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuffs.

Biological Activity

Research has found that L-isoserine showed the ability to inhibit Aminopeptidase N (APN) at a half-maximal inhibitory concentration (IC50 ) value of 563 μM, which could serve as a new lead compound for further chemical modification and optimization. In addition, it has been reported that L-isoserine-L-leucine dipeptide shows moderate aminopeptidase B inhibitory activity (IC50 of 140 μM). This evidence indicates that the incorporation of an amino acid to L-isoserine may contribute to its inhibitory activity against APN. L-isoserine induces long-lasting effects by increasing the expression of GAT3 (glial GABA transporte) in peri-infarct regions[1-2].

References

[1] Yang K , et al. Synthesis of a novel series of L-isoserine derivatives as aminopeptidase N inhibitors. Journal of Enzyme inhibition and Medicinal Chemistry, 2011; 27: 302-310.
[2] Lie M , et al. GAT3 selective substrate l-isoserine upregulates GAT3 expression and increases functional recovery after a focal ischemic stroke in mice. Journal of Cerebral Blood Flow & Metabolism, 2017; 39.

L-Isoserine Preparation Products And Raw materials

Raw materials

Preparation Products

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L-Isoserine Suppliers

Americas 1 China 169 Europe 3 Germany 4 India 4 Japan 3 Switzerland 1 United Kingdom 5 United States 24 Global 214

Alchem Pharmtech,Inc.

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View Lastest Price from L-Isoserine manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: L-Isoserine 632-13-3
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1T+
Release date: 2023-09-21

Career Henan Chemical Co

Product: L-Isoserine 632-13-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-01-03

632-13-3, L-IsoserineRelated Search:

DL-2-AMINOPROPIONIC ANHYDRIDE DL-ISOSERINE,DL-ISOSERINE 99+% (2r,3s)-n-tert-butoxycarbonyl-3-phenyl-isoserine methyl ester,METHYL (2R,3S)-N-BOC-3-PHENYL ISOSERINE FMOC-DL-ISOSERINE,N-BETA-(9-FLUORENYLMETHOXYCARBONYL)-DL-ISOSERINE (S)-IsoserineL-Isoserine,(R)-ISOSERINE ISOSERINE, N-BETA-T-BUTOXYCARBONYL-DL-ISOSERINE N-(T-BOC)-3-PHENYL ISOSERINE ETHYL ESTER D-Isoserine Isoserine, N,N-dimethyl- (6CI) FMOC-ISOSERINE 2R,3S-N-BENZOYLPHENYL ISOSERINE ( TAXOL SIDE CHAI Isoserine, N-glycyl- (3CI) BOC-ISOSERINE ISOSERINE BOC-ISOSERINE, Isoserine, N-2-pyridyl-, methyl ester, DL- (6CI) N-boca mino phenyl isoserine

(S)-ISOSERINE

(S)-2-HYDROXY-B-ALANINE

(S)-2-HYDROXY-BETA-ALANINE

(S)-3-AMINO-2-HYDROXYPROPIONIC ACID

L-ISOSERINE

(s)-2-hydroxy-β-alanine

(S)-LSOSERINE

(2S)-3-AMINO-2-HYDROXY-PROPANOIC ACID

(-)-3-Amino-L-lactic acid

(S)-3-Amino-2-hydroxypropanoic acid

(S)-2-Hydroxy-β-alanine, (S)-3-Amino-2-hydroxypropionic acid

L-Isoserine&gt

Propanoic acid, 3-amino-2-hydroxy-, (2S)-

(2S)-3-amino-2-hydroxypropanoicaci

L-Isoserine USP/EP/BP

Terbutaline Impurity 60

632-13-3

288-16-5

632-11-1632-13-3

632-13-2

Specialty Synthesis

Serine Derivatives

Unnatural Amino Acid Derivatives

Peptide Synthesis

(intermediate of isepamicin)