ChemicalBook > CAS DataBase List > ETHYL 3,3,3-TRIFLUOROPROPIONATE

ETHYL 3,3,3-TRIFLUOROPROPIONATE

Product Name
ETHYL 3,3,3-TRIFLUOROPROPIONATE
CAS No.
352-23-8
Chemical Name
ETHYL 3,3,3-TRIFLUOROPROPIONATE
Synonyms
Ethyl 3,3,3-trifluoropropanoate;uoropropionate;RARECHEM AL BI 1046;ETHYL 3,3,3-TRIFLUOROPROPIOTE;ETHYL 3,3,3-TRIFLUOROPROPIONATE;Ethyl3,3,3-trifluoropropionate97%;Ethyl 3,3,3-trifluoropropionate 97%;Ethyl 3,3,3-trifluoropropanoate 97%;Propanoic acid, 3,3,3-trifluoro-, ethyl ester
CBNumber
CB4397142
Molecular Formula
C5H7F3O2
Formula Weight
156.1
MOL File
352-23-8.mol
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ETHYL 3,3,3-TRIFLUOROPROPIONATE Property

Melting point:
109 °C
Boiling point:
50°C 12mm
Density 
1.192
refractive index 
1.3912
Flash point:
8℃
storage temp. 
2-8°C
solubility 
Chloroform (Sparingly), Ethyl Acetate (Soluble)
form 
Oil
color 
Colourless
InChI
InChI=1S/C5H7F3O2/c1-2-10-4(9)3-5(6,7)8/h2-3H2,1H3
InChIKey
FMDMKDPUFQNVSH-UHFFFAOYSA-N
SMILES
C(OCC)(=O)CC(F)(F)F
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Safety

Hazard Codes 
F,Xi
Risk Statements 
10
Safety Statements 
16-24/25
RIDADR 
3272
Hazard Note 
Flammable
HazardClass 
IRRITANT, FLAMMABLE
HS Code 
29159000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TRC
Product number
B440230
Product name
ethyl3,3,3-trifluoropropanoate
Packaging
2.5g
Price
$130
Updated
2021/12/16
Frontier Specialty Chemicals
Product number
JK487457
Product name
Ethyl3,3,3-trifluoropropionate
Purity
97%
Packaging
5g
Price
$178
Updated
2021/12/16
Oakwood
Product number
034728
Product name
Ethyl 3,3,3-Trifluoropropionate
Packaging
25g
Price
$185
Updated
2021/12/16
AK Scientific
Product number
X0327
Product name
Ethyl3,3,3-trifluoropropionate
Packaging
10g
Price
$191
Updated
2021/12/16
SynQuest Laboratories
Product number
2123-3-71
Product name
Ethyl 3,3,3-trifluoropropionate
Purity
97%
Packaging
25g
Price
$235
Updated
2021/12/16
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ETHYL 3,3,3-TRIFLUOROPROPIONATE Chemical Properties,Usage,Production

Synthesis Reference(s)

Tetrahedron Letters, 32, p. 7689, 1991 DOI: 10.1016/0040-4039(91)80566-O

Synthesis

421-90-9

917-58-8

352-23-8

4.4 General procedure for the preparation of ethyl 3,3,3-trifluoropropionate: (1) To a stirred suspension of potassium ethoxide (KOEt, 5.0 g, 59.4 mmol) in ether (Et2O, 200 mL), a solution of 2,2,3-tribromo-1,1,1-trifluoropropane (7, 6.0 g, 17.9 mmol) in ether (Et2O, 50 mL) was slowly added dropwise. The reaction mixture was stirred at room temperature for 15 min. Subsequently, the reaction was quenched with 1 M aqueous hydrochloric acid (50 mL) and stirring was continued for 30 min. The aqueous layer was separated and extracted with ether (50 mL × 3) and the combined organic phases were washed with brine (40 mL) and dried with anhydrous magnesium sulfate (MgSO4). The solvent was removed by concentration under reduced pressure to give the crude product. Purification of the crude product by distillation afforded ethyl 3,3,3-trifluoropropionate (1, 2.0 g, 72%) as a colorless oil with a boiling point of 106°C (760 mmHg). Product characterization data: IR (pure): 2989, 1747, 1384, 1360, 1267, 1216, 1110, 1026, 929, 836, 755, 653 cm-1. 1H NMR (400 MHz, CDCl3): δ 4.24 (q, J = 7.2 Hz, 2H), 3.17 (q, J = 10.1 Hz, 2H), 1.30 (t, J = 7.2 Hz, 3H). 13C NMR (100 MHz, CDCl3): δ 164.1 (q, JCF = 4.1 Hz, 1C), 123.4 (q, JCF = 274.5 Hz, 1C), 61.7 (1C), 39.5 (q, JCF = 30.8 Hz, 1C), 13.8 (1C). 19F NMR (376 MHz, CDCl3): δ -64.8 (t, JHF = 10.1 Hz, 3F). EI-MS m/z (relative abundance): 156 [M]+ (2.4), 141 [M-Me]+ (1.4), 129 [M+2H-Et]+ (8.2), 111 [M-OEt]+ (100), 91 [CF2CHCO]+ (12.9), 83 [CF3CH2]+ (15.7), 69 [CF3]+ (7.5) , 45 [EtO]+ (41.4).

References

[1] Journal of Fluorine Chemistry, 2014, vol. 167, p. 135 - 138

ETHYL 3,3,3-TRIFLUOROPROPIONATE Preparation Products And Raw materials

Raw materials

Preparation Products

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ETHYL 3,3,3-TRIFLUOROPROPIONATE Suppliers

China 101 Germany 2 India 2 Russia 1 United Kingdom 2 United States 12 Global 120
SHANG FLUORO
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Wuhan Chemwish Technology Co., Ltd
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Jia Xing Isenchem Co.,Ltd
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Pure Chemistry Scientific Inc.
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View Lastest Price from ETHYL 3,3,3-TRIFLUOROPROPIONATE manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
Ethyl 3,3,3-trifluoropropanoate 352-23-8
Price
US $1.10-9.90/KG
Min. Order
1KG
Purity
99%min
Supply Ability
100KG
Release date
2025-08-20
Henan Aochuang Chemical Co.,Ltd.
Product
ETHYL 3,3,3-TRIFLUOROPROPIONATE 352-23-8
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-10-09
Career Henan Chemical Co
Product
ETHYL 3,3,3-TRIFLUOROPROPIONATE 352-23-8
Price
US $3.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
200KG
Release date
2020-01-08

352-23-8, ETHYL 3,3,3-TRIFLUOROPROPIONATERelated Search:

TRIFLUOROMETHYLMALEIC ANHYDRIDE Ethyl trifluoropyruvate Perfluoropropionic anhydride ETHYL PENTAFLUOROPROPIONATE ETHYL 2-ETHOXY-2,3,3,3-TETRAFLUOROPROPANOATE ETHYL 2-CHLORO-3,3,3-TRIFLUORO-2-ISOCYANATOPROPANOATE ETHYL 2-CHLOROTETRAFLUOROPROPIONATE ETHYL 2-BROMO-2,3,3,3-TETRAFLUOROPROPIONATE ETHYL 2-(4-AMINO-3-METHOXYPHENYL)-3,3,3-TRIFLUORO-2-HYDROXYPROPANOATE ETHYL 2-[(2-CHLOROACETYL)AMINO]-3,3,3-TRIFLUORO-2-HYDROXYPROPANOATE HYDRATE ETHYL 2-CHLORO-2-[(3-CHLOROBENZOYL)AMINO]-3,3,3-TRIFLUOROPROPANOATE ETHYL 2-CHLORO-2-[(ETHOXYCARBONYL)AMINO]-3,3,3-TRIFLUOROPROPANOATE ETHYL 2-CHLORO-2-[(4-CHLOROBENZOYL)AMINO]-3,3,3-TRIFLUOROPROPANOATE 5-CHOLESTEN-3BETA-OL 3-(2',2',2'-TRIFLUOROETHYLCARBONATE) 3,3,3-TRIFLUORO-2-HYDROXY-2-(4-METHYLAMINO-PHENYL)-PROPIONIC ACID ETHYL ESTER ETHYL 2-(BUTYRYLAMINO)-3,3,3-TRIFLUORO-2-HYDROXYPROPANOATE ETHYL 2-CHLORO-3,3,3-TRIFLUORO-2-(PROPIONYLAMINO)PROPANOATE ETHYL 2-CHLORO-2-[(2-CHLOROACETYL)AMINO]-3,3,3-TRIFLUOROPROPANOATE

  • RARECHEM AL BI 1046
  • ETHYL 3,3,3-TRIFLUOROPROPIONATE
  • Ethyl 3,3,3-trifluoropropionate 97%
  • Ethyl3,3,3-trifluoropropionate97%
  • Ethyl 3,3,3-trifluoropropanoate
  • Propanoic acid, 3,3,3-trifluoro-, ethyl ester
  • Ethyl 3,3,3-trifluoropropanoate 97%
  • ETHYL 3,3,3-TRIFLUOROPROPIOTE
  • uoropropionate
  • 352-23-8