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4-tert-Butylbenzenesulfonamide

Product Name
4-tert-Butylbenzenesulfonamide
CAS No.
6292-59-7
Chemical Name
4-tert-Butylbenzenesulfonamide
Synonyms
BUTTPARK 44\03-78;Bosentan USP RC E;p-Tosylbenzylamine;Bosentan EP Impurity-E;Bosentan USP Impurity E;t-Butyl bezene sulfonamide;4-t-Butylbenzenesulfonamide;Bosentan Related Compound 2;Bosentan Related CoMpound E;4-t-Butylbenzenesulphonamide
CBNumber
CB4406783
Molecular Formula
C10H15NO2S
Formula Weight
213.3
MOL File
6292-59-7.mol
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4-tert-Butylbenzenesulfonamide Property

Melting point:
136-138°C
Boiling point:
337.2±35.0 °C(Predicted)
Density 
1.152±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly), Ethyl Acetate (Sparingly)
form 
Solid
pka
10.22±0.10(Predicted)
color 
White to Off-White
InChIKey
KYDZEZNYRFJCSA-UHFFFAOYSA-N
CAS DataBase Reference
6292-59-7(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
20/21/22
Safety Statements 
22-36/37/39
Hazard Note 
Irritant
HS Code 
29350090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
1076160
Product name
Bosentan Related Compound E
Packaging
15mg
Price
$1300
Updated
2025/07/31
TCI Chemical
Product number
B3837
Product name
4-tert-Butylbenzenesulfonamide
Purity
>98.0%(HPLC)(N)
Packaging
5g
Price
$29
Updated
2025/07/31
TRC
Product number
B690735
Product name
4-tert-Butylbenzenesulfonamide
Packaging
10g
Price
$110
Updated
2021/12/16
Matrix Scientific
Product number
074999
Product name
4-t-Butylbenzenesulfonamide
Purity
95+%
Packaging
25g
Price
$72
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB140626
Product name
4-(tert-Butyl)benzenesulfonamide
Packaging
50g
Price
$75
Updated
2021/12/16
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4-tert-Butylbenzenesulfonamide Chemical Properties,Usage,Production

Chemical Properties

White solid

Uses

4-tert-Butylbenzenesulfonamide is an intermediate as well as a degradation impurity of the endothelin receptor antagonist Bosentan (B675900).

Synthesis

15084-51-2

6292-59-7

A solution of 4-(tert-butyl)benzenesulfonyl chloride (2.30 g, 10.0 mmol) in dichloromethane (100 mL) was added to a 500 mL round bottom flask at 0 °C, followed by the slow addition of concentrated ammonia (50 mL, 100 mmol, 10 equiv). The reaction mixture was gradually warmed to room temperature and stirred continuously for 20 hours. Upon completion of the reaction, the solvent was removed by evaporation under reduced pressure and the resulting slurry was filtered through a Brinell funnel to afford 1.60 g (75% yield) of 4-(tert-butyl)benzenesulfonamide (Compound A) as a white solid.

References

[1] Chemische Berichte, 1993, vol. 126, # 7, p. 1713 - 1722
[2] Journal of Medicinal Chemistry, 2001, vol. 44, # 21, p. 3355 - 3368
[3] Patent: US2004/39033, 2004, A1. Location in patent: Page/Page column 16; 64
[4] European Journal of Medicinal Chemistry, 2004, vol. 39, # 10, p. 835 - 847
[5] Bioorganic and Medicinal Chemistry, 2017, vol. 25, # 16, p. 4397 - 4406

4-tert-Butylbenzenesulfonamide Preparation Products And Raw materials

Raw materials

Preparation Products

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4-tert-Butylbenzenesulfonamide Suppliers

Americas 1 Belgium 1 Canada 2 China 218 Europe 3 Finland 1 France 2 Germany 5 India 57 Japan 2 Slovakia 1 South Korea 1 Switzerland 3 The Netherlands 1 United Kingdom 13 United States 30 Global 341
P&S Chemicals
Tel
--
Fax
--
Email
info@pschemicals.com
Country
The Netherlands
ProdList
2724
Advantage
58
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View Lastest Price from 4-tert-Butylbenzenesulfonamide manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
4-tert-Butylbenzenesulfonamide 6292-59-7
Price
US $0.00-0.00/KG
Min. Order
50KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-25
Henan Fengda Chemical Co., Ltd
Product
4-tert-Butylbenzenesulfonamide 6292-59-7
Price
US $100.00-1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2023-12-25
Hong Kong Tiansheng New Material Trading Co., Ltd
Product
4-tert-Butylbenzenesulfonamide 6292-59-7
Price
US $28.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1 ton
Release date
2021-12-13

6292-59-7, 4-tert-ButylbenzenesulfonamideRelated Search:

N-n-Butyl benzene sulfonamide 4-tert-Butylbenzoyl chloride Methyl 4-tert-butylbenzoate tert-Butyl methyl ether Benzenesulfonamide Sulfanilamide 3-Aminobenzenesulfonamide 4-tert-Butylphenol tert-Butanol 4-tert-Butyl-N-(6-chloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl)benzenesulfonamide 4,6-Dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine BenzenesulfonaMide, N,N'-[1,2-ethanediylbis[oxy[5-(2-Methoxyphenoxy)[2,2'-bipyriMidine]-6,4-diyl]]]bis[4-(1,1-diMethylethyl)- BenzenesulfonaMide, N-[1,6-dihydro-5-(2-Methoxyphenoxy)-6-oxo[2,2'-bipyriMidin]-4-yl]-4-(1,1-diMethylethyl)- Bosentan Related Compound 4 Bosentan Related Compound 5 Bosentan Impurity 15 HCl 2-Bromo-N-tert-butylbenzenesulfonamide Recombinant Human Telomerase

  • BUTTPARK 44\03-78
  • 4-TERT-BUTYLBENZENESULFONAMIDE
  • 4-TERT-BUTYLBENZENESULPHONAMIDE
  • 4-(TERT-BUTYL)BENZENE-1-SULFONAMIDE
  • P-TERT-BUTYL-BENZENESULFONAMIDE
  • TertiaryButylBenzeneSulphonamide
  • 4-(1,1-DIMETHYLETHYL)BENZENESULFONAMIDE
  • 4-TERT-BUTYLBENZENESULFONAMIDE (SEE 5062)
  • 4-t-Butylbenzenesulphonamide
  • Bosentan USP RC E
  • 4-t-Butylbenzenesulfonamide
  • Bosentan Related Compound 2
  • Bosentan Related Compound E (15 mg) (4-(tert-butyl)benzenesulfonamide)
  • Tert-butyl benzene sulfonamide
  • t-Butyl bezene sulfonamide
  • Bosentan USP Related Compound E: 4-(tert-Butyl)benzenesulfonamide
  • 4-Tertiarybutylbenzene sulphonamine
  • Bosentan Related CoMpound E
  • 4-tert-Butylbenzenesulfomide
  • Bosentan USP Related Compound E
  • Tert. Butyl Benzene Sulphonamide
  • 4-tert-Butylbenzenesulfonamide &gt
  • Benzenesulfonamide, 4-(1,1-dimethylethyl)-
  • 4-tert-Butylbenzenesulfonamide ISO 9001：2015 REACH
  • 4-(tert-Butyl)benzene-1-sulfonamideQ: What is 4-(tert-Butyl)benzene-1-sulfonamide Q: What is the CAS Number of 4-(tert-Butyl)benzene-1-sulfonamide Q: What is the storage condition of 4-(tert-Butyl)benzene-1-sulfonamide Q: What are the applications of 4-(tert-Butyl)benzene-1-sulfonamide
  • Bosentan Related Compound E (4-(tert-butyl)benzenesulfonamide) (1076160)
  • 4-Tertiarybutylbenzene sulphonamide
  • Bosentan Impurity 12(Bosentan USP Related Compound E)
  • Bosentan USP Impurity E
  • 4-TERT-BUTYLBENZENESULFONAMIDE–98%
  • Bosentan EP Impurity-E
  • p-Tosylbenzylamine
  • 6292-59-7
  • Aromatics
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals