Dihydrocoumarin

ChemicalBook > CAS DataBase List > Dihydrocoumarin

Description Sources

Product Name: Dihydrocoumarin
CAS No.: 119-84-6
Chemical Name: Dihydrocoumarin
Synonyms: 3,4-DIHYDROCOUMARIN;CHROMAN-2-ONE;HYDROCOUMARIN;3,4-DIHYDRO-2H-1-BENZOPYRAN-2-ONE;2H-1-Benzopyran-2-one, 3,4-dihydro-;MELILOTIN;3,4-Dihydro-1-benzopyran-2-one;Tonkamel;FEMA 2381;MELILOTOL
CBNumber: CB4413174
Molecular Formula: C9H8O2
Formula Weight: 148.16
MOL File: 119-84-6.mol

Less

Dihydrocoumarin Property

Melting point:: 24-25 °C (lit.)
Boiling point:: 272 °C (lit.)
Density: 1.169 g/mL at 25 °C (lit.)
vapor pressure: 13.6kPa at 20℃
FEMA: 2381 | DIHYDROCOUMARIN
refractive index: n20/D 1.556(lit.)
Flash point:: >230 °F
storage temp.: Sealed in dry,2-8°C
solubility: Chloroform, Methanol (Sparingly)
form: Solid
color: Colourless to Off-White
Specific Gravity: 1.169
Odor: at 10.00 % in dipropylene glycol. sweet tonka coumarinic coconut herbal cinnamon balsamic
Odor Type: tonka
Water Solubility: insoluble
JECFA Number: 1171
BRN: 4584
LogP: 1.82 at 25℃
CAS DataBase Reference: 119-84-6(CAS DataBase Reference)
NIST Chemistry Reference: 2H-1-Benzopyran-2-one, 3,4-dihydro-(119-84-6)
EPA Substance Registry System: 3,4-Dihydrocoumarin (119-84-6)

Less

Safety

Hazard Codes: Xn
Risk Statements: 22-36/37/38
Safety Statements: 26-36
WGK Germany: 3
RTECS: MW5775000
TSCA: Yes
HS Code: 29322980
Hazardous Substances Data: 119-84-6(Hazardous Substances Data)
Toxicity: The acute oral LD₅₀ value in rats was reported as 1.65 g/kg (1.47-1.83 g/ kg) (Moreno, 1972a). The acute dermal LD₅₀ value in rabbits was reported as > 5 g/kg (Moreno, 1972b).

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: W238104
Product name: Dihydrocoumarin
Purity: ≥99%, FCC, FG
Packaging: 1kg
Price: $80.9
Updated: 2024/03/01

Sigma-Aldrich

Product number: W238104
Product name: Dihydrocoumarin
Purity: ≥99%, FCC, FG
Packaging: 5kg
Price: $217
Updated: 2024/03/01

Sigma-Aldrich

Product number: W238104
Product name: Dihydrocoumarin
Purity: ≥99%, FCC, FG
Packaging: 10Kg
Price: $360
Updated: 2024/03/01

Sigma-Aldrich

Product number: D104809
Product name: Dihydrocoumarin
Purity: 99%
Packaging: 5g
Price: $36.3
Updated: 2024/03/01

Sigma-Aldrich

Product number: 07552
Product name: Dihydrocoumarin
Purity: analytical standard
Packaging: 1ml
Price: $69.5
Updated: 2022/05/15

Less

Dihydrocoumarin Chemical Properties,Usage,Production

Description

With a sweet, creamy, and herbal, fragrance, with a slightly burnt taste, dihydrocoumarin (DHC) is used as a flavoring agent in food, tobacco, soap, and perfume, etc. Its exotic flavor is well suited for caramel, nuts, dairy, vanilla, tropical fruit, and alcohol. It is a eukaryotic metabolite found in tonka beans grown in northern South America, from which it was isolated as early as the 1820s, as well as sweet clover. Other uses include as an organic solvent and pharmaceutical intermediary. It has been shown to influence the epigenetic process of human cells in vitro.

Sources

http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:16151
http://www.bojensen.net/EssentialOilsEng/EssentialOils29/EssentialOils29.htm#Tonka
https://books.google.kg/books?id=pUEqBgAAQBAJ&pg=PA427&lpg=PA427&dq=dihydrocoumarin+uses&source=bl&ots=HTZrffvsXu&sig=GPGKqrMRXQaRJ-qgHk7aULeBmGw&hl=en&sa=X&redir_esc=y#v=onepage&q=dihydrocoumarin%20uses&f=false
https://products.symrise.com/aroma-molecules/product-search/dihydrocoumarin/action/pdf/
http://www.lookchem.com/3-4-Dihydrocoumarin/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1315280/

Chemical Properties

Dihydrocoumarin forms colorless crystals (mp 24°C) with a sweet, herbal odor. Dihydrocoumarin is prepared by hydrogenation of coumarin, for example, in the presence of a Raney nickel catalyst. Another process employs the vapor-phase dehydrogenation of hexahydrocoumarin in the presence of Pd or Pt-Al₂O₃ catalysts . Hexahydrocoumarin is prepared by cyanoethylation of cyclohexanone and hydrolysis of the nitrile group, followed by ring closure to the lactone.

Chemical Properties

Dihydrocoumarin has an odor similar to coumarin at room temperature or reminiscent of nitrobenzene at higher temperature. It has a burning taste.

Occurrence

Reported found in Melilotus officinalis, from which it may be extracted by water distillation.

Uses

Hydrocoumarin can be used as a reagent to prepare splitomicin analogs as inhibitors of Sir2.

Uses

Dihydrocoumarin may be used as an analytical reference standard for the determination of the analyte in guaco extracts and pharmaceutical preparations, and various plant extracts by chromatography-based techniques and capillary electrophoresis.

Preparation

Dihydrocoumarin is synthesized by reduction of coumarin under pressure in the presence of nickel at 160 to 200°C or in the presence of Pd-BaSO4 in alcoholic solution.

Definition

ChEBI: A chromanone that is the 3,4-dihydro derivative of coumarin.

Synthesis Reference(s)

Tetrahedron Letters, 37, p. 4555, 1996 DOI: 10.1016/0040-4039(96)00902-1

General Description

Viscous, almost colorless liquid, solidifying in the cold, melting at 23° C. Sp. Gr. 1.19. B.P. 272° C. Slightly soluble in water, soluble in alcohol, miscible with oils.
Sweet-herbaceous, nutlike, haylike odor, usually described as "coumannic" or "tobacco-like".

Air & Water Reactions

Solutions of the chemical in water are stable for less than two hours. Insoluble in water.

Reactivity Profile

Hydrocoumarin is a lactone (behaves as an ester). Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides. Hydrocoumarin may hydrolyze under alkaline or acidic conditions.

Fire Hazard

Hydrocoumarin is combustible.

Biochem/physiol Actions

Taste at 10 ppm

Dihydrocoumarin Preparation Products And Raw materials

Raw materials

Coumarin trans-Cinnamic acid

Preparation Products

Less

Dihydrocoumarin Suppliers

Americas 1 Belgium 1 Canada 2 China 341 Czech 1 Europe 2 France 2 Germany 9 India 15 Italy 2 Japan 6 Mexico 1 Slovakia 1 South Africa 1 South Korea 1 Spain 2 Switzerland 3 United Kingdom 14 United States 71 USA 1 Global 477

Shanghai GaoLang Chemical Technology Co., Ltd.

Tel: 021-57340939 18017297327
Fax: 021-37210791
Email: sales@gaolangchemical.com
Country: China
ProdList: 892
Advantage: 55

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44689
Advantage: 61

Beijing Ouhe Technology Co., Ltd

Tel: 010-82967028 13552068683
Fax: +86-10-82967029
Email: 2355560935@qq.com
Country: China
ProdList: 12390
Advantage: 60

JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
Country: China
ProdList: 9976
Advantage: 60

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42958
Advantage: 64

jiliang chemicals

Tel: 21-62165282 15801962796;
Fax: 021 61153784
Email: bidingchem@163.com
Country: China
ProdList: 1200
Advantage: 60

Shandong Xiya Chemical Co., Ltd

Tel: 4009903999 13355009207
Fax: 0539-6365991
Email: 3007715519@qq.com
Country: China
ProdList: 18738
Advantage: 57

Syntechem Co.,Ltd

Tel
Fax: E-Mail Inquiry
Email: info@syntechem.com
Country: China
ProdList: 12984
Advantage: 57

Sichuan Kulinan Technology Co., Ltd

Tel: 400-1166-196 18981987031
Fax: 028-84555506 800101999
Email: cdhxsj@163.com
Country: China
ProdList: 11707
Advantage: 57

China Langchem Inc.

Tel: 0086-21-58956006
Fax: 0086-21-58956100
Country: China
ProdList: 7811
Advantage: 57

RYSS TECH LTD

Tel: 400-188-0725 +86 21 34310725 13611771617
Fax: +86 21 34311076
Country: China
ProdList: 2002
Advantage: 57

Tianjin heowns Biochemical Technology Co., Ltd.

Tel: 400 638 7771
Email: sales@heowns.com
Country: China
ProdList: 14435
Advantage: 57

Sinopharm Chemical Reagent Co,Ltd.

Tel: 86-21-63210123
Fax: 86-21-63290778 86-21-63218885
Email: sj_scrc@sinopharm.com
Country: China
ProdList: 9815
Advantage: 79

Maya High Purity Chemicals

Tel: +86 (573) 82222445 (0)18006601000 452520369
Fax: +86 (573) 82222643
Email: sales@maya-r.com
Country: China
ProdList: 11707
Advantage: 57

Beijing Taiya Jie Technology Development Co., Ltd.

Tel: 021-33690831-8001 13552411790
Fax: 021-33690831
Email: postmaster@tyjchem.cn
Country: China
ProdList: 1541
Advantage: 55

Spectrum Chemical Manufacturing Corp.

Tel: 021-021-021-67601398-809-809-809 15221380277
Fax: 021-57711696
Email: marketing_china@spectrumchemical.com
Country: China
ProdList: 9658
Advantage: 60

Qingdao Free Trade Zone United International Co.,Ltd.

Tel: 0532-83893697 18561902820
Fax: 83893695
Email: sissili@unitedint.com
Country: China
ProdList: 352
Advantage: 58

Shanghai civi chemical technology co.,Ltd

Tel: 86-21-34053660
Fax: 86-21-34053661
Email: sale@labgogo.com
Country: China
ProdList: 9865
Advantage: 52

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66099280 17798518460
Fax: (1)02557626880
Email: cfzhang@aikonchem.com
Country: China
ProdList: 19915
Advantage: 55

9ding chemical ( Shanghai) Limited

Tel: 4009209199
Fax: 86-021-52271987
Email: sales@9dingchem.com
Country: China
ProdList: 18209
Advantage: 56

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-400-6206333 18521732826
Fax: 021-50323701
Email: market@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

The future of Shanghai Industrial Co., Ltd.

Tel: 021-61552785
Fax: 021-55660885
Email: sales@shshiji.com
Country: China
ProdList: 9545
Advantage: 55

Shanghai Raise Chemical Technology Co.,Ltd

Tel: +86-021-50935922
Fax: +86-021-33847795
Country: China
ProdList: 7865
Advantage: 55

Anichem Inc.

Tel: 0512-69369885
Fax: 0512-69369880
Email: sales@anichem.com.cn
Country: China
ProdList: 495
Advantage: 55

Shanghai Tauto Biotech Co., Ltd.

Tel: 021-51320588
Fax: 0086-21-51320502
Email: tauto@tautobiotech.com
Country: China
ProdList: 3989
Advantage: 66

Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd.

Tel: +86-28-85122536 85324413
Fax: +86-28-85326443
Email: market@astatech.cn
Country: China
ProdList: 8026
Advantage: 55

TargetMol Chemicals Inc.

Tel: 021-021-33632979 15002134094
Fax: 021-33632979
Email: marketing@targetmol.com
Country: China
ProdList: 7783
Advantage: 58

Quzhou Juhua Friendship Co., Ltd

Tel: 0570-3066667
Fax: 0570-3063388
Country: China
ProdList: 3930
Advantage: 58

Shanghai JONLN Reagent Co., Ltd.

Tel: 400-0066400 13621662912
Fax: 021-55660885
Email: 422131432@qq.com
Country: China
ProdList: 9978
Advantage: 55

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 41462
Advantage: 60

Sichuan Wei Keqi Biological Technology Co., Ltd.

Tel: 028-81700200 18116577057
Fax: 028-81705658
Email: 3003855609@qq.com
Country: China
ProdList: 7787
Advantage: 56

Wuxi Zhongkun Biochemical Technology Co., Ltd.

Tel: 0510-85629785 18013409632
Fax: 051085625359
Email: sales@reading-chemicals.com
Country: China
ProdList: 15178
Advantage: 58

Finetech Industry Limited

Tel: 027-87465837 19945049750
Fax: 027-8777-2287
Email: sales@finetechnology-ind.com
Country: China
ProdList: 9648
Advantage: 58

Shanghai Aspire Biological Technology Co., Ltd.

Tel: 021-61317773
Fax: 021-61486878
Email: sales@aspirebio.com
Country: China
ProdList: 2880
Advantage: 58

Hunan HuaTeng Pharmaceutical Co., Ltd.,

Tel: 400-8592883 15367835770
Fax: 0731-82251112
Email: viola@huatengsci.com
Country: China
ProdList: 5873
Advantage: 58

Shanghai CanSpecsci Instrument Co., Ltd.

Tel: 400-6087598 15021221957
Fax: 4006087598-8012
Email: order@canspecsci.com
Country: China
ProdList: 2045
Advantage: 56

Suzhou yacoo science co.,Ltd

Tel: 0512-87182056 18013166090
Fax: 0512-87182056
Email: lingling.qi@yacoo.com.cn
Country: China
ProdList: 7295
Advantage: 60

Shanghai Macklin Biochemical Co.,Ltd.

Tel: 15221275939 15221275939
Fax: 021-50706099
Email: shenlinxing@macklin.cn
Country: China
ProdList: 16166
Advantage: 55

Hangzhou J&H Chemical Co., Ltd.

Tel: 0571-+86-571-87396432
Fax: 0571-87396431
Email: sales@jhechem.com
Country: China
ProdList: 11663
Advantage: 59

Wuhan Dahua Weiye Pharmaceutical Chemical Co., Ltd.

Tel: 027-59420981,18702770802
Fax: 027-83322098
Country: China
ProdList: 1975
Advantage: 50

Shanghai Yongye Biotechnology Co., Ltd.

Tel: 86-021-61559134 15921386130
Fax: 021-55068248
Email: 3423497944@qq.com
Country: China
ProdList: 8144
Advantage: 55

Shanghai Song Yuan Chemical Technology Co., Ltd.

Tel: 010-1234567 18521000990
Fax: 86-021-33275113
Email: sonyuanchemical@163.com
Country: China
ProdList: 6479
Advantage: 50

Cool Pharm, Ltd

Tel: 021-58581007 18019463053
Fax: 50966098
Email: sales@coolpharm.com
Country: China
ProdList: 12346
Advantage: 58

Hubei Jusheng Technology Co.,Ltd

Tel: 027-59599241 18871490274
Fax: 027-59599241
Email: 1400878000@qq.com
Country: China
ProdList: 9958
Advantage: 58

Changsha Jing Kang New Material Technology Co., Ltd.

Tel: 0731-85118349 18874718518
Fax: 0731-85118349
Email: ma_haihong@sina.com
Country: China
ProdList: 1595
Advantage: 50

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51456
Advantage: 80

Struchem Co., Ltd.

Tel: 0512-0512-63009836 15365350169
Fax: 0512-63006936
Email: helen@struchem.com
Country: China
ProdList: 3984
Advantage: 60

Less

View Lastest Price from Dihydrocoumarin manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: Dihydrocoumarin 119-84-6
Price: US $100.00-45.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20ton
Release date: 2024-05-06

Hebei Weibang Biotechnology Co., Ltd

Product: Cinnamic acid 119-84-6
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 5tons
Release date: 2024-12-03

Shandong Deshang Chemical Co., Ltd.

Product: Dihydrocoumarin 119-84-6
Price: US $10.00-7.00/kg
Min. Order: 1kg
Purity: 99.99%
Supply Ability: 10 tons
Release date: 2024-06-07

119-84-6, DihydrocoumarinRelated Search:

Nickel Potassium cinnamate Ethanol Sodium bicarbonate URANIUM Barium hydroxide Metronidazole Dihydrocoumarin 4-HYDROXY MEPHENYTOIN 3-Phenylpropionic acid Vanillin 6,7-DIMETHOXY-4-METHYL-CHROMAN-2-ONE 3-[(Z)-ANILINOMETHYLIDENE]-2H-CHROMENE-2,4-DIONE 3-[(Z)-(3-CHLOROANILINO)METHYLIDENE]-2H-CHROMENE-2,4-DIONE 3-(2,6-DICHLOROPHENYL)-3A,9B-DIHYDRO-4H-CHROMENO[3,4-D]ISOXAZOL-4-ONE 4-(4-CHLOROPHENYL)-5,7-DIHYDROXY-2-CHROMANONE 3-((Z)-[4-(TRIFLUOROMETHYL)ANILINO]METHYLIDENE)-2H-CHROMENE-2,4-DIONE Hydrocoumarin, 6-acetamido-3-(1-pyrrolidinylcarbonyl)-

AKOS 222-08

3,4-Dihydro-1-benzopyran-2-one

3,4-DIHYDRO-2H-1-BENZOPYRAN-2-ONE

3,4-DIHYDROCOUMARIN

Hydrocoumarin,6-methyl-4phenyl-3,4dihydro-6-methyl-4-phenyl-2h-benzopyran-2-one

Dihydrocoumarin 1g [119-84-6]

Dihydrocoumarin,3,4-Dihydro-1-benzopyran-2-one, Benzodihydropyrone, Hydrocoumarin

DIHYDROCOUMARIN,3,4-(RG)

3,4-dihydrobenzopyran-2-one

DIHYDROCOUMARIN FOR SYNTHESIS

DihydrocouMarin 99%

Two hydrogen

2-Chromanone

2-oxo-chroma

3,4-dihydro-2h-1-benzopyran-2-on

3,4-dihydro-coumari

3,4-Dihydroxycoumarin

Benzopyranone, dihydro-

Chroman, 2-oxo-

Coumarin, 3,4-dihydro-

Hydrocinnamic acid, o-hydroxy-, delta-lactone

1,2-BENZODIHYDROPYRONE

BENZODIHYDROPYRONE

DIHYDROBENZENOPYRONE

DIHYDROBENZOPYRONE

DIHYDROCOUMARIN

DIHYDROCOUMARIN,3,4-

CHROMAN-2-ONE

HYDROCOUMARIN

FEMA 2381

MELILOTIN

MELILOTINE

MELILOTOL

meliloticlactone

NCI-C55890

o-hydroxy-hydrocinnamicacidelta-lactone

oxochroman

USAF do-12

usafdo-12

2H-1-Benzopyran-2-one, 3,4-dihydro-

3,4-Dihydroqoumarin

2H-1-BENZOPYRAN-2-ONE,3,4-D

8-Azabicyclo[3.2.1]octan-3-one, 8-(phenylmethyl)-

4H-1-Benzopyran-2(3H)-one

Dihydrocoumarin,99%

3,4-Dihydro-1-benzopyran-2-one, Benzodihydropyrone, Hydrocoumarin

Tonkamel

DIHYDROCOUMARIN 99+% FCC

3,4-Dihydrocoumarin &gt

Dihydrocoumarin@1000 μg/mL in Acetone

Cinnamic acid USP/EP/BP

Meliotine Coumarin, 3, 4-Dihydro- 3, 4-Dyhydrocoumarin CAS 119-84-6

3,4-dihydrochromen-2-one

ihydrocoumarin

119-84-6

Heterocyclic Building Blocks

Coumarins

Building Blocks