4-Cloromethyl-5-methyl-1,3-dioxol-2-one

Product Name: 4-Cloromethyl-5-methyl-1,3-dioxol-2-one
CAS No.: 80841-78-7
Chemical Name: 4-Cloromethyl-5-methyl-1,3-dioxol-2-one
Synonyms: DMDO-CL;4-CHLOROMETHYL-5-METHYL-1,3-DIOXOL-2-ONE;Olmesartan impurity;4-ChloroMethyl-5-Methyl-1;AZATMint-C;DMDO-Chloride;Olmesartan Impurity 3;Olmesartan Impurity 57;Olmesartan Medoxomil IMP;4,5- dinmethyl-1,3-dioxol-2-
CBNumber: CB4416605
Molecular Formula: C5H5ClO3
Formula Weight: 148.54
MOL File: 80841-78-7.mol

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4-Cloromethyl-5-methyl-1,3-dioxol-2-one Property

Boiling point:: >90℃/2mm
Density: 1.362±0.06 g/cm3(Predicted)
refractive index: 1.4760-1.4820
Flash point:: 129 °C
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Chloroform (Slightly), Methanol (Slightly)
form: liquid
color: Colorless to Light yellow to Light orange
Specific Gravity: 1.36
BRN: 4798926
InChI: InChI=1S/C5H5ClO3/c1-3-4(2-6)9-5(7)8-3/h2H2,1H3
InChIKey: QCLFSYYUWPUWQR-UHFFFAOYSA-N
SMILES: CC1=C(OC(=O)O1)CCl
CAS DataBase Reference: 80841-78-7(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 22-36/37/38
Safety Statements: 26
WGK Germany: 3
HS Code: 29329990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H301Toxic if swalloed

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: C1882
Product name: 4-Chloromethyl-5-methyl-1,3-dioxol-2-one
Purity: >94.0%(GC)
Packaging: 5g
Price: $77
Updated: 2025/07/31

TCI Chemical

Product number: C1882
Product name: 4-Chloromethyl-5-methyl-1,3-dioxol-2-one
Purity: >94.0%(GC)
Packaging: 25g
Price: $281
Updated: 2025/07/31

TRC

Product number: C369335
Product name: 4-Chloromethyl-5-methyl-1,3-dioxol-2-one
Packaging: 1g
Price: $65
Updated: 2021/12/16

TRC

Product number: C369335
Product name: 4-Chloromethyl-5-methyl-1,3-dioxol-2-one
Packaging: 10g
Price: $175
Updated: 2021/12/16

Oakwood

Product number: 079667
Product name: 4-(Chloromethyl)-5-methyl-1,3-dioxol-2-one
Packaging: 250mg
Price: $10
Updated: 2021/12/16

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4-Cloromethyl-5-methyl-1,3-dioxol-2-one Chemical Properties,Usage,Production

Description

4-Chloromethyl-5-methyl-1,3-dioxol-2-one is a useful branch side chain for synthetic penicillin esters such as Lenampicillin, Mecillinam, etc. It can improve the stability and absorption of drugs, increase biological activity, and reduce side effects. It is also used to prepare amine drugs, such as Norfloxacin prodrug. In the prior art, the primary method for synthesizing 4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one is a chlorination reaction of chlorine gas or N-chlorosuccinimide.

Chemical Properties

Colorless to Light yellow to Light orange clear liquid or Pale Yellow Oil.

Uses

4-Chloromethyl-5-methyl-1,3-dioxol-2-one is an important reagent in the preparation of angiotensin II receptor antagonist such as Olmesratan Medoxomil (O550000). It is also used in the preparation of prodrugs of ampicillin.

Preparation

4,5-dimethyl-1,3-dioxole-2-ketone (DMDO) is used as raw material, taking sulfonic acid chloride as a chlorinating agent. The reaction is reat under the effect of a catalyzer in organic solvent and reacts for 1-5 hours to obtain target product 4-Cloromethyl-5-methyl-1,3-dioxol-2-one.

Synthesis

37830-90-3

80841-78-7

General procedure for the synthesis of 4-chloromethyl-5-methyl-1,3-dioxolan-2-one from 4,5-dimethyl-1,3-dioxolan-2-one: To a stirred solution of 4,5-dimethyl-1,3-dioxolan-2-one (DMDO) were added 4725 g of ethylene dichloride, 10.12.5 g of N-chlorosuccinimide (NCS) and 45 g of benzoyl peroxide (BPO), the reaction temperature was maintained at 90 °C, and the reaction lasted for 5.5 h. The crude product 4-chloromethyl-5-methyl-1,3-dioxolen-2-one (DMDO-Cl) was obtained as 382.5 g in 85.00% yield. Step 3: distillation: the crude product of DMDO-Cl was distilled under vacuum at -0.1 MPa at 110 °C to obtain 326 g of DMDO-Cl. Its purity was 99.06% as determined by gas chromatography (GC).

References

[1] Chemical and Pharmaceutical Bulletin, 1984, vol. 32, # 6, p. 2241 - 2248
[2] Chemical and Pharmaceutical Bulletin, 1988, vol. 36, # 1, p. 394 - 397
[3] Patent: US4554358, 1985, A
[4] Patent: CN107892681, 2018, A. Location in patent: Paragraph 0015-0022

4-Cloromethyl-5-methyl-1,3-dioxol-2-one Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Cloromethyl-5-methyl-1,3-dioxol-2-one Suppliers

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View Lastest Price from 4-Cloromethyl-5-methyl-1,3-dioxol-2-one manufacturers

HANGZHOU HAILAN CHEMICAL CO.,LTD.

Product: 4-Cloromethyl-5-methyl-1,3-dioxol-2-one 80841-78-7
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%min
Supply Ability: 2000KGS
Release date: 2025-10-24

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 4-Cloromethyl-5-methyl-1,3-dioxol-2-one 80841-78-7
Price: US $0.00/Kg/Drum
Min. Order: 1KG
Purity: 98%min
Supply Ability: 1000kgs
Release date: 2021-09-29

Hebei Chuanghai Biotechnology Co., Ltd

Product: 4-Cloromethyl-5-methyl-1,3-dioxol-2-one 80841-78-7
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-29

80841-78-7, 4-Cloromethyl-5-methyl-1,3-dioxol-2-oneRelated Search:

4-Methyl-2-pentanone Mesotrione Methyl cellulose Kresoxim-methyl Methylparaben Norgestrel Bensulfuron methyl METSULFURON METHYL Methyl acrylate 4,5-Dimethyl-1,3-dioxol-2-one 4-Bromomethyl-5-methyl-1,3-dioxol-2-one N-Methyl-2-pyrrolidone tert-Butyldimethylsilyl chloride Methanol Cyclopentene Olmesartan Olmesartan Methyl

DMDO-CL

4-Cloromethyl-5-methyl-1,3-dioxol-2-one

Olmesartan Impurity 57

4-CloroMethyl-5-Methyl-1,3-dioxol-2-one (DMDO-Cl)

OlMesartan IMpurity (4-(ChloroMethyl)-5-Methyl-1,3-Dioxol-2-one)

4- chloroMethyl-5- Methyl-1,3- two oxygenheterocyclicpentadiene-2- ketone

-5--1,3- two4-chloroMethylMethylcyclopentene-2- ketoneheterocyclic oxygen

4-ChloroMethyl-5-Methyl-l,3-dioxocyclopenten-2–one

DMDO-CL: 4-(chloromethyl)-5-methyl-1,3-dioxol-2-one

Olmesartan impurity

Olmesartan Medoxomil IMP

AZATMint-C

4-( Cyclomethyl carbonyl ) -5 - methyl – 1,3-dioxol-2-one ( OLM 45 )

Olmesartan Impurity 3

4-Cloromethyl-5-methyl-1,3-dioxol-2-one in stock Factory

Olmesartan Medoxomil Impurity 56

Olmesartan Medoxomil Impurity 5

4-CHLOROMETHYL-5-METHYL-2-OXO-1,3-DIOXOLE

4-CHLOROMETHYL-5-METHYL-1,3-DIOXOL-2-ONE

4-CHLOROMETHYL-5-METHYL-1,3-DIOXOLEN-2-ONE

DMDO CL (4-METHYL-5-CHLOROMETHYL-1,3-DIOXOL-2-ONE)

4-Chloromethyl-5-Methyl-1,3-Dioxol-2-One(Dmdo-Cl)

4-Chloromethyl-5-Methyl-1,3-Dioxocyclopenten-2-one

4-Chloromethyl-5-methyl-2H-1,3-dioxol-2-one

4-Choromethyl-5-methyl-2-oxo-1,3-dioxole

4-Chloromethyl-5-Methyl-1,3-Di

4-CHLOROMETHYL-5-METHYL-1,3-DIOXOL-3-ONE

4-methyl-5-chloro methyl-1,3-dioxol-2-one

4-CHLOROMETHYL-5-METHYL-1,3-DIOXOL-2-ONE (INTERMEDIATE OF OLMESARTAN MEDOXOMIL)

4-Chloromethyl-5-methyl-1,3-dioxol-2-on

4-CHLOROMETHYL-5-METHYL-1,3-DIOXOL-2-ONE HPLC 95%

4-Methyl-5-(chloromethyl)-1,3-dioxole-2-one

4-ChloroMethyl-5-Methyl-1

4-chloroMethyl-5-Methyl-1,3-dioxdene-2-one

(5-Methyl-2-oxo-1,3-dioxol-4-yl)Methyl Chloride

4-(chloroMethyl)-5-Methyl-1,3-dioxol-2-oneSynonyMs

1,3-Dioxol-2-one, 4-(chloromethyl)-5-methyl-

Olmesartan Medoxomil Impurity 5 (4-(Chloromethyl)-5-methyl-1,3-Dioxol-2-one)

4-Chloromethyl-5-methyl-1,3-dioxol-2-one &gt

Olmesartan Chloromethyl Impurity

Olmesartan Medoxomil EP Impurity

4-Cloromethyl-5-methyl-1,3-dioxol-2-one ISO 9001：2015 REACH

4-chloromethyl-5-methyl-1,3-Dioxol-2-oneQ: What is 4-chloromethyl-5-methyl-1,3-Dioxol-2-one Q: What is the CAS Number of 4-chloromethyl-5-methyl-1,3-Dioxol-2-one Q: What is the storage condition of 4-chloromethyl-5-methyl-1,3-Dioxol-2-one Q: What are the applications of 4-chloromethyl-5-methyl-1,3-Dioxol-2-one

4-CHLORO METHYL-5-METHYL-1,3-DAIOXOL,2-ONE(DMDO.CL)

4,5- dinmethyl-1,3-dioxol-2-

4-ChlDMDO-Cloromethyl-5-methyl-1,3-dioxol-2-one

4-Chloromethyl-5-methyl-1,3-Dioxole -2-one (DMDO CL)

4-Chloromethyl-5-MethyI-1 ,3-Diox0l-2-One(DMDO-CI)

4-Chlomethyl-5-methy1-1,3,dioxol-2-one

Olmesartan Medoxomil Impurity 5 (5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl Chloride

4-Chloromethyl-5-Methyl-1,3-Dioxol-2-One(DMDO-CI)

4-chloromethyl-5-methyl-1,3-dioxolane-2-one

4-Chloromethyl-5-methyl-1,3-dioxl-2-one

DMDO-Chloride

4-Chloromethyl-5-methyl-1,3-Dioxol-2-one (DMDO Chloride )

80841-78-7

C5H5ClO3

C5H5O3Cl