4-Cloromethyl-5-methyl-1,3-dioxol-2-one

Product Name: 4-Cloromethyl-5-methyl-1,3-dioxol-2-one
CAS No.: 80841-78-7
Chemical Name: 4-Cloromethyl-5-methyl-1,3-dioxol-2-one
Synonyms: DMDO-CL;4-CHLOROMETHYL-5-METHYL-1,3-DIOXOL-2-ONE;Olmesartan impurity;4-ChloroMethyl-5-Methyl-1;AZATMint-C;Olmesartan Impurity 3;Olmesartan Impurity 57;Olmesartan Medoxomil IMP;4,5- dinmethyl-1,3-dioxol-2-;4-Chloromethyl-5-Methyl-1,3-Di
CBNumber: CB4416605
Molecular Formula: C5H5ClO3
Formula Weight: 148.54
MOL File: 80841-78-7.mol

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4-Cloromethyl-5-methyl-1,3-dioxol-2-one Property

Boiling point:: >90℃/2mm
Density: 1.362±0.06 g/cm3(Predicted)
refractive index: 1.4760-1.4820
Flash point:: 129 °C
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Chloroform (Slightly), Methanol (Slightly)
form: liquid
color: Colorless to Light yellow to Light orange
Specific Gravity: 1.36
BRN: 4798926
InChI: InChI=1S/C5H5ClO3/c1-3-4(2-6)9-5(7)8-3/h2H2,1H3
InChIKey: QCLFSYYUWPUWQR-UHFFFAOYSA-N
SMILES: CC1=C(OC(=O)O1)CCl
CAS DataBase Reference: 80841-78-7(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 22-36/37/38
Safety Statements: 26
WGK Germany: 3
HS Code: 29329990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H301Toxic if swalloed

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: C1882
Product name: 4-Chloromethyl-5-methyl-1,3-dioxol-2-one
Purity: >94.0%(GC)
Packaging: 5g
Price: $85
Updated: 2024/03/01

TCI Chemical

Product number: C1882
Product name: 4-Chloromethyl-5-methyl-1,3-dioxol-2-one
Purity: >94.0%(GC)
Packaging: 25g
Price: $312
Updated: 2024/03/01

Alfa Aesar

Product number: H55735
Product name: 4-Chloromethyl-5-methyl-2-oxo-1,3-dioxole, 97%
Packaging: 1g
Price: $56.65
Updated: 2024/03/01

Alfa Aesar

Product number: H55735
Product name: 4-Chloromethyl-5-methyl-2-oxo-1,3-dioxole, 97%
Packaging: 5g
Price: $189.65
Updated: 2024/03/01

Alfa Aesar

Product number: H55735
Product name: 4-Chloromethyl-5-methyl-2-oxo-1,3-dioxole, 97%
Packaging: 250mg
Price: $19.3
Updated: 2023/06/20

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4-Cloromethyl-5-methyl-1,3-dioxol-2-one Chemical Properties,Usage,Production

Description

4-Chloromethyl-5-methyl-1,3-dioxol-2-one is a useful branch side chain for synthetic penicillin esters such as Lenampicillin, Mecillinam, etc. It can improve the stability and absorption of drugs, increase biological activity, and reduce side effects. It is also used to prepare amine drugs, such as Norfloxacin prodrug. In the prior art, the primary method for synthesizing 4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one is a chlorination reaction of chlorine gas or N-chlorosuccinimide.

Chemical Properties

Colorless to Light yellow to Light orange clear liquid or Pale Yellow Oil.

Uses

4-Chloromethyl-5-methyl-1,3-dioxol-2-one is an important reagent in the preparation of angiotensin II receptor antagonist such as Olmesratan Medoxomil (O550000). It is also used in the preparation of prodrugs of ampicillin.

Preparation

4,5-dimethyl-1,3-dioxole-2-ketone (DMDO) is used as raw material, taking sulfonic acid chloride as a chlorinating agent. The reaction is reat under the effect of a catalyzer in organic solvent and reacts for 1-5 hours to obtain target product 4-Cloromethyl-5-methyl-1,3-dioxol-2-one.

4-Cloromethyl-5-methyl-1,3-dioxol-2-one Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Cloromethyl-5-methyl-1,3-dioxol-2-one Suppliers

Americas 1 Canada 4 China 422 Europe 4 France 1 Germany 7 India 90 Japan 4 Switzerland 2 Ukraine 1 United Kingdom 13 United States 53 Global 602

Sansheng Pharmaceutical Industrial Co.,Ltd.

Tel: 0373-3329121 15716685442
Fax: 0373-3329121
Email: 1658822522@qq.com
Country: China
ProdList: 7
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TaiZhou ZhiCheng Chemicals & Technology Co., LTD.

Tel: 0523-82837785 13914525028
Fax: 0523-87913272
Email: info@jszchg.com
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J & K SCIENTIFIC LTD.

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3B Pharmachem (Wuhan) International Co.,Ltd.

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Email: 3bsc@sina.com
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future industrial shanghai co., ltd

Tel: 400-0066400 13621662912
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Email: sales@jonln.com
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Alfa Aesar

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Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
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TAIYUAN RHF CO.,LTD.

Tel: +86 351 7031519
Fax: +86 351 7031519
Email: sales@RHFChem.com
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TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Ark Pharm, Inc.

Tel: 847-367-3680
Fax: 847-367-3681
Email: sales@arkpharminc.com
Country: United States
ProdList: 1670
Advantage: 56

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44689
Advantage: 61

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View Lastest Price from 4-Cloromethyl-5-methyl-1,3-dioxol-2-one manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 4-Cloromethyl-5-methyl-1,3-dioxol-2-one 80841-78-7
Price: US $0.00/Kg/Drum
Min. Order: 1KG
Purity: 98%min
Supply Ability: 1000kgs
Release date: 2021-09-29

airuikechemical co., ltd.

Product: 4-cloromethyl-5-methyl-1,3-dioxol-2-one 80841-78-7
Price: US $0.00-0.00/Kg
Min. Order: 1Kg
Purity: 99.9%
Supply Ability: 200tons
Release date: 2024-04-08

Hebei Ganmiao New material Technology Co., LTD

Product: 4-Cloromethyl-5-methyl-1,3-dioxol-2-one 80841-78-7
Price: US $10.00-7.00/kg
Min. Order: 1kg
Purity: 99.9%
Supply Ability: 20ton
Release date: 2024-06-05

80841-78-7, 4-Cloromethyl-5-methyl-1,3-dioxol-2-oneRelated Search:

4-Methyl-2-pentanone Mesotrione Methyl cellulose Kresoxim-methyl Methylparaben Norgestrel Bensulfuron methyl METSULFURON METHYL Methyl acrylate 4,5-Dimethyl-1,3-dioxol-2-one 4-Bromomethyl-5-methyl-1,3-dioxol-2-one N-Methyl-2-pyrrolidone tert-Butyldimethylsilyl chloride Methanol Cyclopentene Olmesartan Olmesartan Methyl

DMDO-CL

4-Cloromethyl-5-methyl-1,3-dioxol-2-one

Olmesartan Impurity 57

4-CloroMethyl-5-Methyl-1,3-dioxol-2-one (DMDO-Cl)

OlMesartan IMpurity (4-(ChloroMethyl)-5-Methyl-1,3-Dioxol-2-one)

4- chloroMethyl-5- Methyl-1,3- two oxygenheterocyclicpentadiene-2- ketone

-5--1,3- two4-chloroMethylMethylcyclopentene-2- ketoneheterocyclic oxygen

4-ChloroMethyl-5-Methyl-l,3-dioxocyclopenten-2–one

DMDO-CL: 4-(chloromethyl)-5-methyl-1,3-dioxol-2-one

Olmesartan impurity

Olmesartan Medoxomil IMP

AZATMint-C

4-( Cyclomethyl carbonyl ) -5 - methyl – 1,3-dioxol-2-one ( OLM 45 )

Olmesartan Impurity 3

4-Cloromethyl-5-methyl-1,3-dioxol-2-one in stock Factory

Olmesartan Medoxomil Impurity 56

Olmesartan Medoxomil Impurity 5

4-CHLOROMETHYL-5-METHYL-2-OXO-1,3-DIOXOLE

4-CHLOROMETHYL-5-METHYL-1,3-DIOXOL-2-ONE

4-CHLOROMETHYL-5-METHYL-1,3-DIOXOLEN-2-ONE

DMDO CL (4-METHYL-5-CHLOROMETHYL-1,3-DIOXOL-2-ONE)

4-Chloromethyl-5-Methyl-1,3-Dioxol-2-One(Dmdo-Cl)

4-Chloromethyl-5-Methyl-1,3-Dioxocyclopenten-2-one

4-Chloromethyl-5-methyl-2H-1,3-dioxol-2-one

4-Choromethyl-5-methyl-2-oxo-1,3-dioxole

4-Chloromethyl-5-Methyl-1,3-Di

4-CHLOROMETHYL-5-METHYL-1,3-DIOXOL-3-ONE

4-methyl-5-chloro methyl-1,3-dioxol-2-one

4-CHLOROMETHYL-5-METHYL-1,3-DIOXOL-2-ONE (INTERMEDIATE OF OLMESARTAN MEDOXOMIL)

4-Chloromethyl-5-methyl-1,3-dioxol-2-on

4-CHLOROMETHYL-5-METHYL-1,3-DIOXOL-2-ONE HPLC 95%

4-Methyl-5-(chloromethyl)-1,3-dioxole-2-one

4-ChloroMethyl-5-Methyl-1

4-chloroMethyl-5-Methyl-1,3-dioxdene-2-one

(5-Methyl-2-oxo-1,3-dioxol-4-yl)Methyl Chloride

4-(chloroMethyl)-5-Methyl-1,3-dioxol-2-oneSynonyMs

1,3-Dioxol-2-one, 4-(chloromethyl)-5-methyl-

Olmesartan Medoxomil Impurity 5 (4-(Chloromethyl)-5-methyl-1,3-Dioxol-2-one)

4-Chloromethyl-5-methyl-1,3-dioxol-2-one &gt

Olmesartan Chloromethyl Impurity

Olmesartan Medoxomil EP Impurity

4-Cloromethyl-5-methyl-1,3-dioxol-2-one ISO 9001：2015 REACH

4-chloromethyl-5-methyl-1,3-Dioxol-2-oneQ: What is 4-chloromethyl-5-methyl-1,3-Dioxol-2-one Q: What is the CAS Number of 4-chloromethyl-5-methyl-1,3-Dioxol-2-one Q: What is the storage condition of 4-chloromethyl-5-methyl-1,3-Dioxol-2-one Q: What are the applications of 4-chloromethyl-5-methyl-1,3-Dioxol-2-one

4-CHLORO METHYL-5-METHYL-1,3-DAIOXOL,2-ONE(DMDO.CL)

4,5- dinmethyl-1,3-dioxol-2-

4-ChlDMDO-Cloromethyl-5-methyl-1,3-dioxol-2-one

4-Chloromethyl-5-methyl-1,3-Dioxole -2-one (DMDO CL)

Olmesartan Medoxomil Impurity 5 (5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl Chloride

4-Chloromethyl-5-MethyI-1 ,3-Diox0l-2-One(DMDO-CI)

4-Chlomethyl-5-methy1-1,3,dioxol-2-one

80841-78-7

C5H5ClO3

C5H5O3Cl

Carbonates

Carbonyl Compounds

Organic Building Blocks

Pharmaceutical Intermediates

INTERMEDIATESOF