4-Cloromethyl-5-methyl-1,3-dioxol-2-one
- Product Name
- 4-Cloromethyl-5-methyl-1,3-dioxol-2-one
- CAS No.
- 80841-78-7
- Chemical Name
- 4-Cloromethyl-5-methyl-1,3-dioxol-2-one
- Synonyms
- DMDO-CL;4-CHLOROMETHYL-5-METHYL-1,3-DIOXOL-2-ONE;Olmesartan impurity;4-ChloroMethyl-5-Methyl-1;AZATMint-C;Olmesartan Impurity 3;Olmesartan Impurity 57;Olmesartan Medoxomil IMP;4,5- dinmethyl-1,3-dioxol-2-;4-Chloromethyl-5-Methyl-1,3-Di
- CBNumber
- CB4416605
- Molecular Formula
- C5H5ClO3
- Formula Weight
- 148.54
- MOL File
- 80841-78-7.mol
4-Cloromethyl-5-methyl-1,3-dioxol-2-one Property
- Boiling point:
- >90℃/2mm
- Density
- 1.362±0.06 g/cm3(Predicted)
- refractive index
- 1.4760-1.4820
- Flash point:
- 129 °C
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- liquid
- color
- Colorless to Light yellow to Light orange
- Specific Gravity
- 1.36
- BRN
- 4798926
- InChI
- InChI=1S/C5H5ClO3/c1-3-4(2-6)9-5(7)8-3/h2H2,1H3
- InChIKey
- QCLFSYYUWPUWQR-UHFFFAOYSA-N
- SMILES
- CC1=C(OC(=O)O1)CCl
- CAS DataBase Reference
- 80841-78-7(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26
- WGK Germany
- 3
- HS Code
- 29329990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H301Toxic if swalloed
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- C1882
- Product name
- 4-Chloromethyl-5-methyl-1,3-dioxol-2-one
- Purity
- >94.0%(GC)
- Packaging
- 5g
- Price
- $85
- Updated
- 2024/03/01
- Product number
- C1882
- Product name
- 4-Chloromethyl-5-methyl-1,3-dioxol-2-one
- Purity
- >94.0%(GC)
- Packaging
- 25g
- Price
- $312
- Updated
- 2024/03/01
- Product number
- H55735
- Product name
- 4-Chloromethyl-5-methyl-2-oxo-1,3-dioxole, 97%
- Packaging
- 1g
- Price
- $56.65
- Updated
- 2024/03/01
- Product number
- H55735
- Product name
- 4-Chloromethyl-5-methyl-2-oxo-1,3-dioxole, 97%
- Packaging
- 5g
- Price
- $189.65
- Updated
- 2024/03/01
- Product number
- H55735
- Product name
- 4-Chloromethyl-5-methyl-2-oxo-1,3-dioxole, 97%
- Packaging
- 250mg
- Price
- $19.3
- Updated
- 2023/06/20
4-Cloromethyl-5-methyl-1,3-dioxol-2-one Chemical Properties,Usage,Production
Description
4-Chloromethyl-5-methyl-1,3-dioxol-2-one is a useful branch side chain for synthetic penicillin esters such as Lenampicillin, Mecillinam, etc. It can improve the stability and absorption of drugs, increase biological activity, and reduce side effects. It is also used to prepare amine drugs, such as Norfloxacin prodrug. In the prior art, the primary method for synthesizing 4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one is a chlorination reaction of chlorine gas or N-chlorosuccinimide.
Chemical Properties
Colorless to Light yellow to Light orange clear liquid or Pale Yellow Oil.
Uses
4-Chloromethyl-5-methyl-1,3-dioxol-2-one is an important reagent in the preparation of angiotensin II receptor antagonist such as Olmesratan Medoxomil (O550000). It is also used in the preparation of prodrugs of ampicillin.
Preparation
4,5-dimethyl-1,3-dioxole-2-ketone (DMDO) is used as raw material, taking sulfonic acid chloride as a chlorinating agent. The reaction is reat under the effect of a catalyzer in organic solvent and reacts for 1-5 hours to obtain target product 4-Cloromethyl-5-methyl-1,3-dioxol-2-one.
4-Cloromethyl-5-methyl-1,3-dioxol-2-one Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Cloromethyl-5-methyl-1,3-dioxol-2-one manufacturers
- Product
- 4-Cloromethyl-5-methyl-1,3-dioxol-2-one 80841-78-7
- Price
- US $0.00/Kg/Drum
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 1000kgs
- Release date
- 2021-09-29
- Product
- 4-Cloromethyl-5-methyl-1,3-dioxol-2-one 80841-78-7
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-29
- Product
- 4-cloromethyl-5-methyl-1,3-dioxol-2-one 80841-78-7
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1Kg
- Purity
- 99.9%
- Supply Ability
- 200tons
- Release date
- 2024-04-08