ChemicalBook > CAS DataBase List > 4-Cloromethyl-5-methyl-1,3-dioxol-2-one

4-Cloromethyl-5-methyl-1,3-dioxol-2-one

Product Name
4-Cloromethyl-5-methyl-1,3-dioxol-2-one
CAS No.
80841-78-7
Chemical Name
4-Cloromethyl-5-methyl-1,3-dioxol-2-one
Synonyms
DMDO-CL;4-CHLOROMETHYL-5-METHYL-1,3-DIOXOL-2-ONE;Olmesartan impurity;4-ChloroMethyl-5-Methyl-1;AZATMint-C;Olmesartan Impurity 3;Olmesartan Impurity 57;Olmesartan Medoxomil IMP;4,5- dinmethyl-1,3-dioxol-2-;4-Chloromethyl-5-Methyl-1,3-Di
CBNumber
CB4416605
Molecular Formula
C5H5ClO3
Formula Weight
148.54
MOL File
80841-78-7.mol
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4-Cloromethyl-5-methyl-1,3-dioxol-2-one Property

Boiling point:
>90℃/2mm
Density 
1.362±0.06 g/cm3(Predicted)
refractive index 
1.4760-1.4820
Flash point:
129 °C
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
liquid
color 
Colorless to Light yellow to Light orange
Specific Gravity
1.36
BRN 
4798926
InChI
InChI=1S/C5H5ClO3/c1-3-4(2-6)9-5(7)8-3/h2H2,1H3
InChIKey
QCLFSYYUWPUWQR-UHFFFAOYSA-N
SMILES
CC1=C(OC(=O)O1)CCl
CAS DataBase Reference
80841-78-7(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
22-36/37/38
Safety Statements 
26
WGK Germany 
3
HS Code 
29329990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H301Toxic if swalloed

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical
Product number
C1882
Product name
4-Chloromethyl-5-methyl-1,3-dioxol-2-one
Purity
>94.0%(GC)
Packaging
5g
Price
$85
Updated
2024/03/01
TCI Chemical
Product number
C1882
Product name
4-Chloromethyl-5-methyl-1,3-dioxol-2-one
Purity
>94.0%(GC)
Packaging
25g
Price
$312
Updated
2024/03/01
Alfa Aesar
Product number
H55735
Product name
4-Chloromethyl-5-methyl-2-oxo-1,3-dioxole, 97%
Packaging
1g
Price
$56.65
Updated
2024/03/01
Alfa Aesar
Product number
H55735
Product name
4-Chloromethyl-5-methyl-2-oxo-1,3-dioxole, 97%
Packaging
5g
Price
$189.65
Updated
2024/03/01
Alfa Aesar
Product number
H55735
Product name
4-Chloromethyl-5-methyl-2-oxo-1,3-dioxole, 97%
Packaging
250mg
Price
$19.3
Updated
2023/06/20
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4-Cloromethyl-5-methyl-1,3-dioxol-2-one Chemical Properties,Usage,Production

Description

4-Chloromethyl-5-methyl-1,3-dioxol-2-one is a useful branch side chain for synthetic penicillin esters such as Lenampicillin, Mecillinam, etc. It can improve the stability and absorption of drugs, increase biological activity, and reduce side effects. It is also used to prepare amine drugs, such as Norfloxacin prodrug. In the prior art, the primary method for synthesizing 4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one is a chlorination reaction of chlorine gas or N-chlorosuccinimide. 

Chemical Properties

Colorless to Light yellow to Light orange clear liquid or Pale Yellow Oil.

Uses

4-Chloromethyl-5-methyl-1,3-dioxol-2-one is an important reagent in the preparation of angiotensin II receptor antagonist such as Olmesratan Medoxomil (O550000). It is also used in the preparation of prodrugs of ampicillin.

Preparation

4,5-dimethyl-1,3-dioxole-2-ketone (DMDO) is used as raw material, taking sulfonic acid chloride as a chlorinating agent. The reaction is reat under the effect of a catalyzer in organic solvent and reacts for 1-5 hours to obtain target product 4-Cloromethyl-5-methyl-1,3-dioxol-2-one.

4-Cloromethyl-5-methyl-1,3-dioxol-2-one Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-Cloromethyl-5-methyl-1,3-dioxol-2-one manufacturers

Hebei Mujin Biotechnology Co.,Ltd
Product
4-Cloromethyl-5-methyl-1,3-dioxol-2-one 80841-78-7
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
5000000kg
Release date
2023-08-17
WUHAN FORTUNA CHEMICAL CO., LTD
Product
4-Cloromethyl-5-methyl-1,3-dioxol-2-one 80841-78-7
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
98%min
Supply Ability
1000kgs
Release date
2021-09-29
airuikechemical co., ltd.
Product
4-cloromethyl-5-methyl-1,3-dioxol-2-one 80841-78-7
Price
US $0.00-0.00/Kg
Min. Order
1Kg
Purity
99.9%
Supply Ability
200tons
Release date
2024-04-08

80841-78-7, 4-Cloromethyl-5-methyl-1,3-dioxol-2-oneRelated Search:

4-Methyl-2-pentanone Mesotrione Methyl cellulose Kresoxim-methyl Methylparaben Norgestrel Bensulfuron methyl METSULFURON METHYL Methyl acrylate 4,5-Dimethyl-1,3-dioxol-2-one 4-Bromomethyl-5-methyl-1,3-dioxol-2-one N-Methyl-2-pyrrolidone tert-Butyldimethylsilyl chloride Methanol Cyclopentene Olmesartan Olmesartan Methyl

  • DMDO-CL
  • 4-Cloromethyl-5-methyl-1,3-dioxol-2-one
  • Olmesartan Impurity 57
  • 4-CloroMethyl-5-Methyl-1,3-dioxol-2-one (DMDO-Cl)
  • OlMesartan IMpurity (4-(ChloroMethyl)-5-Methyl-1,3-Dioxol-2-one)
  • 4- chloroMethyl-5- Methyl-1,3- two oxygenheterocyclicpentadiene-2- ketone
  • -5--1,3- two4-chloroMethylMethylcyclopentene-2- ketoneheterocyclic oxygen
  • 4-ChloroMethyl-5-Methyl-l,3-dioxocyclopenten-2–one
  • DMDO-CL: 4-(chloromethyl)-5-methyl-1,3-dioxol-2-one
  • Olmesartan impurity
  • Olmesartan Medoxomil IMP
  • AZATMint-C
  • 4-( Cyclomethyl carbonyl ) -5 - methyl – 1,3-dioxol-2-one ( OLM 45 )
  • Olmesartan Impurity 3
  • 4-Cloromethyl-5-methyl-1,3-dioxol-2-one in stock Factory
  • Olmesartan Medoxomil Impurity 56
  • Olmesartan Medoxomil Impurity 5
  • 4-CHLOROMETHYL-5-METHYL-2-OXO-1,3-DIOXOLE
  • 4-CHLOROMETHYL-5-METHYL-1,3-DIOXOL-2-ONE
  • 4-CHLOROMETHYL-5-METHYL-1,3-DIOXOLEN-2-ONE
  • DMDO CL (4-METHYL-5-CHLOROMETHYL-1,3-DIOXOL-2-ONE)
  • 4-Chloromethyl-5-Methyl-1,3-Dioxol-2-One(Dmdo-Cl)
  • 4-Chloromethyl-5-Methyl-1,3-Dioxocyclopenten-2-one
  • 4-Chloromethyl-5-methyl-2H-1,3-dioxol-2-one
  • 4-Choromethyl-5-methyl-2-oxo-1,3-dioxole
  • 4-Chloromethyl-5-Methyl-1,3-Di
  • 4-CHLOROMETHYL-5-METHYL-1,3-DIOXOL-3-ONE
  • 4-methyl-5-chloro methyl-1,3-dioxol-2-one
  • 4-CHLOROMETHYL-5-METHYL-1,3-DIOXOL-2-ONE (INTERMEDIATE OF OLMESARTAN MEDOXOMIL)
  • 4-Chloromethyl-5-methyl-1,3-dioxol-2-on
  • 4-CHLOROMETHYL-5-METHYL-1,3-DIOXOL-2-ONE HPLC 95%
  • 4-Methyl-5-(chloromethyl)-1,3-dioxole-2-one
  • 4-ChloroMethyl-5-Methyl-1
  • 4-chloroMethyl-5-Methyl-1,3-dioxdene-2-one
  • (5-Methyl-2-oxo-1,3-dioxol-4-yl)Methyl Chloride
  • 4-(chloroMethyl)-5-Methyl-1,3-dioxol-2-oneSynonyMs
  • 1,3-Dioxol-2-one, 4-(chloromethyl)-5-methyl-
  • Olmesartan Medoxomil Impurity 5 (4-(Chloromethyl)-5-methyl-1,3-Dioxol-2-one)
  • 4-Chloromethyl-5-methyl-1,3-dioxol-2-one &gt
  • Olmesartan Chloromethyl Impurity
  • Olmesartan Medoxomil EP Impurity
  • 4-Cloromethyl-5-methyl-1,3-dioxol-2-one ISO 9001：2015 REACH
  • 4-chloromethyl-5-methyl-1,3-Dioxol-2-oneQ: What is 4-chloromethyl-5-methyl-1,3-Dioxol-2-one Q: What is the CAS Number of 4-chloromethyl-5-methyl-1,3-Dioxol-2-one Q: What is the storage condition of 4-chloromethyl-5-methyl-1,3-Dioxol-2-one Q: What are the applications of 4-chloromethyl-5-methyl-1,3-Dioxol-2-one
  • 4-CHLORO METHYL-5-METHYL-1,3-DAIOXOL,2-ONE(DMDO.CL)
  • 4,5- dinmethyl-1,3-dioxol-2-
  • 4-ChlDMDO-Cloromethyl-5-methyl-1,3-dioxol-2-one
  • 4-Chloromethyl-5-methyl-1,3-Dioxole -2-one (DMDO CL)
  • 4-Chloromethyl-5-MethyI-1 ,3-Diox0l-2-One(DMDO-CI)
  • 4-Chlomethyl-5-methy1-1,3,dioxol-2-one
  • Olmesartan Medoxomil Impurity 5 (5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl Chloride
  • 4-Chloromethyl-5-Methyl-1,3-Dioxol-2-One(DMDO-CI)
  • 4-chloromethyl-5-methyl-1,3-dioxolane-2-one
  • 80841-78-7
  • C5H5ClO3
  • C5H5O3Cl
  • Carbonates
  • Carbonyl Compounds
  • Organic Building Blocks