2-Bromo-7-hydroxynaphthalene
Uses- Product Name
- 2-Bromo-7-hydroxynaphthalene
- CAS No.
- 116230-30-9
- Chemical Name
- 2-Bromo-7-hydroxynaphthalene
- Synonyms
- 7-BROMONAPHTHALEN-2-OL;7-Bromo-2-naphthol;7-Bromo-2-Naphthalenol;BroMonaphthalen-2-ol;Naproxen Impurity 28;7-Bromo-2-naphthol 99%;7-Bromo-2-naphthol >7-Bromonaphthalene-2-ol;2-Naphthalenol,7-broMo-;7-Bromo-2-naphthol, >=98%
- CBNumber
- CB4432461
- Molecular Formula
- C10H7BrO
- Formula Weight
- 223.07
- MOL File
- 116230-30-9.mol
2-Bromo-7-hydroxynaphthalene Property
- Melting point:
- 133-138 °C
- Boiling point:
- 353.8±15.0 °C(Predicted)
- Density
- 1.614±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- form
- powder to crystal
- pka
- 9.17±0.40(Predicted)
- color
- White to Light yellow
- InChI
- InChI=1S/C10H7BrO/c11-9-3-1-7-2-4-10(12)6-8(7)5-9/h1-6,12H
- InChIKey
- VWSBGGRCEQOTNU-UHFFFAOYSA-N
- SMILES
- C1=C2C(C=CC(Br)=C2)=CC=C1O
- CAS DataBase Reference
- 116230-30-9
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 690244
- Product name
- 7-Bromo-2-naphthol
- Purity
- 99%
- Packaging
- 1g
- Price
- $86
- Updated
- 2023/06/20
- Product number
- 690244
- Product name
- 7-Bromo-2-naphthol
- Purity
- 99%
- Packaging
- 5g
- Price
- $409
- Updated
- 2023/06/20
- Product number
- B4580
- Product name
- 7-Bromo-2-naphthol
- Purity
- >97.0%(GC)
- Packaging
- 1g
- Price
- $39
- Updated
- 2025/07/31
- Product number
- B4580
- Product name
- 7-Bromo-2-naphthol
- Purity
- >97.0%(GC)
- Packaging
- 5g
- Price
- $144
- Updated
- 2025/07/31
- Product number
- B686703
- Product name
- 7-Bromonaphthalen-2-ol
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
2-Bromo-7-hydroxynaphthalene Chemical Properties,Usage,Production
Uses
2-Bromo-7-hydroxynaphthalene is used as an intermediate in organic synthesis and pharmaceuticals.
Chemical Properties
White powder
Synthesis
582-17-2
116230-30-9
The general procedure for the synthesis of 7-bromo-2-naphthol from 2,7-dihydroxynaphthalene was as follows: 1. Preparation of 2-bromo-7-methoxynaphthalene: Triphenylphosphine (89.7 g, 0.342 mol) and acetonitrile (350 mL) were added to a 1 L flask under nitrogen protection and the mixture was cooled to 10 °C. Bromine (17.6 mL, 0.342 mol) was added slowly and dropwise over 10 min. After removing the cooling bath, 2,7-dihydroxynaphthalene (50.0 g, 0.312 mol) was added and rinsed with 350 mL of acetonitrile. The resulting yellow-brown mixture was heated to reflux for 3 hours. Subsequently, the acetonitrile was removed by distillation under reduced pressure, taking about 2 hours to give an off-white solid. 2. Preparation of 7-bromo-2-naphthol: The above solid was heated to 280°C within 30 minutes to form a black liquid. The liquid was continued to be heated to 310°C within 20 minutes and maintained at this temperature for 15 minutes until gas release ceased. After the black mixture was cooled to room temperature, 34.5 g of the intermediate title compound was obtained by chromatographic separation as an off-white solid with HPLC purity of 87% (43% yield).
References
[1] Journal of the American Chemical Society, 2008, vol. 130, # 13, p. 4541 - 4552
[2] Dyes and Pigments, 2014, vol. 107, p. 174 - 181
[3] Patent: WO2015/121785, 2015, A1. Location in patent: Page/Page column 32; 33
[4] Helvetica Chimica Acta, 1999, vol. 82, # 7, p. 981 - 1004
[5] Chemical Communications, 2012, vol. 48, # 5, p. 750 - 752
2-Bromo-7-hydroxynaphthalene Preparation Products And Raw materials
Raw materials
Preparation Products
2-Bromo-7-hydroxynaphthalene Suppliers
- Tel
- --
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- Country
- Switzerland
- ProdList
- 6896
- Advantage
- 91
View Lastest Price from 2-Bromo-7-hydroxynaphthalene manufacturers
- Product
- 2-Bromo-7-hydroxynaphthalene 116230-30-9
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-19
- Product
- 2-Bromo-7-hydroxynaphthalene 116230-30-9
- Price
- US $100.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-26
- Product
- 2-Bromo-7-hydroxynaphthalene 116230-30-9
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-11