N,N-Dimethylglycine

ChemicalBook > CAS DataBase List > N,N-Dimethylglycine

N,N-Dimethylglycine

Product Name: N,N-Dimethylglycine
CAS No.: 1118-68-9
Chemical Name: N,N-Dimethylglycine
Synonyms: DMG;DIMETHYLGLYCINE;AKOS BB-5614;n-methylsarcosine;N-DiMethylglycine;N,N-Dimthylglycine;RARECHEM AL BO 0104;N,N-DIMETHYLGLYCINE;n,n-dimethyl-glycin;DMG Dimethylglycine
CBNumber: CB4440420
Molecular Formula: C4H9NO2
Formula Weight: 103.12
MOL File: 1118-68-9.mol

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N,N-Dimethylglycine Property

Melting point:: 178-182 °C(lit.)
Boiling point:: 193.35°C (rough estimate)
Density: 1 g/cm³
refractive index: 1.4674 (estimate)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Methanol (Slightly), Water (Slightly)
pka: 9.89(at 25℃)
form: Crystalline Powder
color: White to slightly yellow
Water Solubility: soluble
Sensitive: Hygroscopic
Merck: 14,3244
BRN: 1700261
InChIKey: FFDGPVCHZBVARC-UHFFFAOYSA-N
CAS DataBase Reference: 1118-68-9(CAS DataBase Reference)
EPA Substance Registry System: Glycine, N,N-dimethyl- (1118-68-9)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 22-36/37/38
Safety Statements: 24/25-36/37-26
WGK Germany: 3
RTECS: MB9865000
F: 3
TSCA: Yes
HazardClass: IRRITANT
HS Code: 29224999
Toxicity: rat,LD50,oral,> 650mg/kg (650mg/kg),BEHAVIORAL: ATAXIABLOOD: CHANGES IN SPLEENGASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA",Acute Toxicity Data. Journal of the American College of Toxicology, Part B. Vol. 1, Pg. 199, 1992.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 05022
Product name: N,N-Dimethylglycine
Purity: for HPLC derivatization, ≥99% (NT)
Packaging: 1g
Price: $59.8
Updated: 2022/05/15

Sigma-Aldrich

Product number: 05022
Product name: N,N-Dimethylglycine
Purity: for HPLC derivatization, ≥99% (NT)
Packaging: 10x1g
Price: $469
Updated: 2022/05/15

TCI Chemical

Product number: D3585
Product name: N,N-Dimethylglycine
Purity: >98.0%(T)
Packaging: 5g
Price: $57
Updated: 2024/03/01

TCI Chemical

Product number: D3585
Product name: N,N-Dimethylglycine
Purity: >98.0%(T)
Packaging: 25g
Price: $166
Updated: 2024/03/01

Alfa Aesar

Product number: A19670
Product name: N,N-Dimethylglycine, 98+%
Packaging: 5g
Price: $76.4
Updated: 2024/03/01

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N,N-Dimethylglycine Chemical Properties,Usage,Production

Description

N,N-Dimethylglycine (DMG) is a N-methylated product of the amino acid glycine. It is found in beans and liver. It can be formed from trimethylglycine upon the loss of one of its methyl groups. It is also a byproduct of the metabolism of choline. When DMG was first discovered, it was referred to as vitamin B16, but, unlike true B vitamins, deficiency of DMG in the diet does not lead to any ill-effects meaning it does not meet the definition of a vitamin. It is used in comparative analysis with other N-methylated glycines. N,N-Dimethylglycine is used in the development of glycine-based ionic liquids and emulsifiers, and as a substrate to identify, differentiate and characterize amino acid methyltransferase(s). It is potentially useful as a biomarker of protein degradation in COPD patients.

Chemical Properties

white to slightly yellow crystalline powder

Uses

N,N-Dimethylglycine is used as an athletic performance enhancer and immunostimulant. It is also used in the treatment of autism, epilepsy and mitochondrial disease. It is also employed as a biomarker of protein degradation in chronic obstructive lung disease (COPD) patients. Further, it is used as a substrate to identify, differentiate and characterize amino acid methyltransferase. It plays an important role for the development of glycine-based ionic liquids and emulsifiers.

Application

N, N-dimethylglycine (DMG) is a tertiary amino acid that naturally occurs as an intermediate metabolite in choline-to-glycine metabolism. It has been suggested for use as an athletic performance enhancer, immunostimulant, and a treatment for autism, epilepsy, or mitochondrial disease . Published studies on the subject have shown little to no difference between DMG treatment and placebo in autism spectrum disorders.

Definition

ChEBI: N,N-dimethylglycine is an N-methylglycine that is glycine carrying two N-methyl substituents. It has a role as a human metabolite, a Daphnia magna metabolite and a mouse metabolite. It is a N-methyl-amino acid and a member of N-methylglycines. It is a tautomer of a N,N-dimethylglycine zwitterion.

Preparation

N,N-Dimethylglycine is commercially available as the free form amino acid, and as the hydrochloride salt [2491-06-7 ]. DMG may be prepared by the alkylation of glycine via the Eschweiler–Clarke reaction. In this reaction, glycine is treated with aqueous formaldehyde in formic acid that serves as both solvent and reductant. Hydrochloric acid is added thereafter to give the hydrochloride salt. The free amino acid may been obtained by neutralization of the acid salt, which has been performed with silver oxide.
H₂NCH₂COOH + 2 CH₂O + 2 HCOOH →(CH₃)₂NCH₂COOH + 2 CO₂ + 2 H₂O.

General Description

N,N-Dimethylglycine is a type of quaternary ammonium compound which exhibits a variety of biological effects.

Biochem/physiol Actions

N,N-Dimethylglycine (DMG) is a natural N-methylated glycine that is used in comparative analysis with other N-methylated glycines such as sarcosine and βine. N,N-Dimethylglycine is used in the development of glycine-based ionic liquids and emulsifiers. N,N-Dimethylglycine is potentially useful as a biomarker of protein degradation in COPD patients. DMG is used as a substrate to identify, differentiate and characterize amino acid methyltransferase(s).

References

J. K. Kern, V. S. Miller, L. Cauller, R. Kendall, J. Mehta, M. Dodd, Effectiveness of N,N-Dimethylglycine in Autism and Pervasive Developmental Disorder, Journal of Child Neurology, 2001, vol. 16, pp. 169-173

N,N-Dimethylglycine Preparation Products And Raw materials

Raw materials

Preparation Products

4-(IMIDAZOL-1-YL)PHENOL

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View Lastest Price from N,N-Dimethylglycine manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: N,N-Dimethylglycine 1118-68-9
Price: US $25.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20ton
Release date: 2024-05-11

Shanghai Aosiris new Material Technology Co., LTD

Product: N,N-Dimethylglycine 1118-68-9
Price: US $3.00-1.00/kg
Min. Order: 1kg
Purity: 99.9%
Supply Ability: 10 tons
Release date: 2024-04-03

Sigma Audley

Product: N,N-Dimethylglycine 1118-68-9
Price: US $35.00-25.00/kg
Min. Order: 1kg
Purity: 99.8%
Supply Ability: 200tons/year
Release date: 2024-03-12

1118-68-9, N,N-DimethylglycineRelated Search:

Sarcosine Ethyl 2-(Chlorosulfonyl)acetate 4-Aminophenylacetic acid 3-Dimethylaminopropylamine Glycine 4-Hydroxy-D-(-)-2-phenylglycine N,N-Dimethylformamide dimethyl acetal Sodium hydroxymethylglycinate Ascoric Acid Ethylenediaminetetraacetic acid disodium salt Thymolphthalein Complexone Diethylenetriaminepentaacetic acid Creatine 1,2-Diaminopropane-N,N,N',N'-tetraacetic acid 1,2-Cyclohexylenedinitrilotetraacetic acid 1,3-DIAMINO-2-PROPANOL-N,N,N',N'-TETRAACETIC ACID Ethylenebis(oxyethylenenitrilo)tetraacetic acid Acetic anhydride Dimethylglycine

DIMETHYLGLYCINE

DIMETHYLGLYCINE(N,N-)

(DIMETHYLAMINO)ACETIC ACID

DMG

AKOS BB-5614

N,N-DIMETHYLAMINOACETIC ACID

N,N-DIMETHYLGLYCINE

RARECHEM AL BO 0104

Glycine,N,N-dimethyl-

n,n-dimethyl-glycin

n-methylsarcosine

N,N-DIMETHYLGLYCINE FREE BASE

2-dimethylaminoacetic acid

N,N-Dimthylglycine

N,N-Dimethylglycine, 98+%

N,N-Dimethylglycine,99%

N-DiMethylglycine

N,N-DiMethylglycine, 97% 5GR

(Dimethylamino)acetic acid, N-Methylsarcosine

N,N-Dimethylglycine ,97%

N,N-Dimethylglycine

N,N-Dimethylglycine

2-(dimethylazaniumyl)acetate

N,N-Dimethylglycine&gt

N,N-Dimethylglycine USP/EP/BP

Dimethyl glycine DMG

Distributor Vitamin B16 / N, N-Dimethylglycine CAS 1118-68-9 Dimethylglycine Powder

DMG Dimethylglycine

Dimethylglycine Powder

1118-68-9

CH32NCH2COOH

CH32NCH2CO2H

CARBOXYLIC ACID

DID - DIN

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