ChemicalBook > CAS DataBase List > N,N-Dimethylglycine

N,N-Dimethylglycine

Product Name
N,N-Dimethylglycine
CAS No.
1118-68-9
Chemical Name
N,N-Dimethylglycine
Synonyms
DMG;DIMETHYLGLYCINE;AKOS BB-5614;n-methylsarcosine;N-DiMethylglycine;N,N-Dimthylglycine;RARECHEM AL BO 0104;N,N-DIMETHYLGLYCINE;n,n-dimethyl-glycin;DMG Dimethylglycine
CBNumber
CB4440420
Molecular Formula
C4H9NO2
Formula Weight
103.12
MOL File
1118-68-9.mol
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N,N-Dimethylglycine Property

Melting point:
178-182 °C(lit.)
Boiling point:
193.35°C (rough estimate)
Density 
1 g/cm3
refractive index 
1.4674 (estimate)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Methanol (Slightly), Water (Slightly)
pka
9.89(at 25℃)
form 
Crystalline Powder
color 
White to slightly yellow
Water Solubility 
soluble
Sensitive 
Hygroscopic
Merck 
14,3244
BRN 
1700261
InChIKey
FFDGPVCHZBVARC-UHFFFAOYSA-N
CAS DataBase Reference
1118-68-9(CAS DataBase Reference)
EPA Substance Registry System
Glycine, N,N-dimethyl- (1118-68-9)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
22-36/37/38
Safety Statements 
24/25-36/37-26
WGK Germany 
3
RTECS 
MB9865000
F 
3
TSCA 
Yes
HazardClass 
IRRITANT
HS Code 
29224999
Toxicity
rat,LD50,oral,> 650mg/kg (650mg/kg),BEHAVIORAL: ATAXIABLOOD: CHANGES IN SPLEENGASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA",Acute Toxicity Data. Journal of the American College of Toxicology, Part B. Vol. 1, Pg. 199, 1992.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
05022
Product name
N,N-Dimethylglycine
Purity
for HPLC derivatization, ≥99% (NT)
Packaging
1g
Price
$59.8
Updated
2022/05/15
Sigma-Aldrich
Product number
05022
Product name
N,N-Dimethylglycine
Purity
for HPLC derivatization, ≥99% (NT)
Packaging
10x1g
Price
$469
Updated
2022/05/15
TCI Chemical
Product number
D3585
Product name
N,N-Dimethylglycine
Purity
>98.0%(T)
Packaging
5g
Price
$57
Updated
2024/03/01
TCI Chemical
Product number
D3585
Product name
N,N-Dimethylglycine
Purity
>98.0%(T)
Packaging
25g
Price
$166
Updated
2024/03/01
Alfa Aesar
Product number
A19670
Product name
N,N-Dimethylglycine, 98+%
Packaging
5g
Price
$76.4
Updated
2024/03/01
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N,N-Dimethylglycine Chemical Properties,Usage,Production

Description

N,N-Dimethylglycine (DMG) is a N-methylated product of the amino acid glycine. It is found in beans and liver. It can be formed from trimethylglycine upon the loss of one of its methyl groups. It is also a byproduct of the metabolism of choline. When DMG was first discovered, it was referred to as vitamin B16, but, unlike true B vitamins, deficiency of DMG in the diet does not lead to any ill-effects meaning it does not meet the definition of a vitamin. It is used in comparative analysis with other N-methylated glycines. N,N-Dimethylglycine is used in the development of glycine-based ionic liquids and emulsifiers, and as a substrate to identify, differentiate and characterize amino acid methyltransferase(s). It is potentially useful as a biomarker of protein degradation in COPD patients.

Chemical Properties

white to slightly yellow crystalline powder

Uses

N,N-Dimethylglycine is used as an athletic performance enhancer and immunostimulant. It is also used in the treatment of autism, epilepsy and mitochondrial disease. It is also employed as a biomarker of protein degradation in chronic obstructive lung disease (COPD) patients. Further, it is used as a substrate to identify, differentiate and characterize amino acid methyltransferase. It plays an important role for the development of glycine-based ionic liquids and emulsifiers.

Application

N, N-dimethylglycine (DMG) is a tertiary amino acid that naturally occurs as an intermediate metabolite in choline-to-glycine metabolism. It has been suggested for use as an athletic performance enhancer, immunostimulant, and a treatment for autism, epilepsy, or mitochondrial disease . Published studies on the subject have shown little to no difference between DMG treatment and placebo in autism spectrum disorders.

Definition

ChEBI: N,N-dimethylglycine is an N-methylglycine that is glycine carrying two N-methyl substituents. It has a role as a human metabolite, a Daphnia magna metabolite and a mouse metabolite. It is a N-methyl-amino acid and a member of N-methylglycines. It is a tautomer of a N,N-dimethylglycine zwitterion.

Preparation

N,N-Dimethylglycine is commercially available as the free form amino acid, and as the hydrochloride salt [2491-06-7 ]. DMG may be prepared by the alkylation of glycine via the Eschweiler–Clarke reaction. In this reaction, glycine is treated with aqueous formaldehyde in formic acid that serves as both solvent and reductant. Hydrochloric acid is added thereafter to give the hydrochloride salt. The free amino acid may been obtained by neutralization of the acid salt, which has been performed with silver oxide.
H2NCH2COOH + 2 CH2O + 2 HCOOH →(CH3)2NCH2COOH + 2 CO2 + 2 H2O.

General Description

N,N-Dimethylglycine is a type of quaternary ammonium compound which exhibits a variety of biological effects.

Biochem/physiol Actions

N,N-Dimethylglycine (DMG) is a natural N-methylated glycine that is used in comparative analysis with other N-methylated glycines such as sarcosine and βine. N,N-Dimethylglycine is used in the development of glycine-based ionic liquids and emulsifiers. N,N-Dimethylglycine is potentially useful as a biomarker of protein degradation in COPD patients. DMG is used as a substrate to identify, differentiate and characterize amino acid methyltransferase(s).

References

J. K. Kern, V. S. Miller, L. Cauller, R. Kendall, J. Mehta, M. Dodd, Effectiveness of N,N-Dimethylglycine in Autism and Pervasive Developmental Disorder, Journal of Child Neurology, 2001, vol. 16, pp. 169-173

N,N-Dimethylglycine Preparation Products And Raw materials

Raw materials

Preparation Products

4-(IMIDAZOL-1-YL)PHENOL
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N,N-Dimethylglycine Suppliers

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View Lastest Price from N,N-Dimethylglycine manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
N,N-Dimethylglycine 1118-68-9
Price
US $25.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-05-11
WUHAN FORTUNA CHEMICAL CO., LTD
Product
N,N-Dimethylglycine 1118-68-9
Price
US $0.00-0.00/Kg/Drum
Min. Order
1KG
Purity
98%min
Supply Ability
1000kg
Release date
2021-12-09
Hebei Weibang Biotechnology Co., Ltd
Product
N,N-Dimethylglycine 1118-68-9
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-06

1118-68-9, N,N-DimethylglycineRelated Search:

Sarcosine Ethyl 2-(Chlorosulfonyl)acetate 4-Aminophenylacetic acid 3-Dimethylaminopropylamine Glycine 4-Hydroxy-D-(-)-2-phenylglycine N,N-Dimethylformamide dimethyl acetal Sodium hydroxymethylglycinate Ascoric Acid Ethylenediaminetetraacetic acid disodium salt Thymolphthalein Complexone Diethylenetriaminepentaacetic acid Creatine 1,2-Diaminopropane-N,N,N',N'-tetraacetic acid 1,2-Cyclohexylenedinitrilotetraacetic acid 1,3-DIAMINO-2-PROPANOL-N,N,N',N'-TETRAACETIC ACID Ethylenebis(oxyethylenenitrilo)tetraacetic acid Acetic anhydride Dimethylglycine

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