10-Hydroxycamptothecin
- Product Name
- 10-Hydroxycamptothecin
- CAS No.
- 19685-09-7
- Chemical Name
- 10-Hydroxycamptothecin
- Synonyms
- SN38;HCPT;HYDROXYCAMPTOTHECIN;10-HCPT;(S)-10-HYDROXYCAMPTOTHECIN;Ampule;NSC 107124;HYDROCAMPTOTHECINE;hydroxy-camptotheci;Irinotecan USP RC A
- CBNumber
- CB4445430
- Molecular Formula
- C20H16N2O5
- Formula Weight
- 364.35
- MOL File
- 19685-09-7.mol
10-Hydroxycamptothecin Property
- Melting point:
- 265-270°C
- Boiling point:
- 820.7±65.0 °C(Predicted)
- Density
- 1.60
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- solubility
- ≥23.8 mg/mL in DMSO with gentle warming; insoluble in EtOH; insoluble in H2O
- pka
- 8.93±0.40(Predicted)
- form
- powder to crystal
- color
- White to Yellow to Orange
- InChIKey
- HAWSQZCWOQZXHI-FQEVSTJZSA-N
- CAS DataBase Reference
- 19685-09-7(CAS DataBase Reference)
Safety
- Safety Statements
- 24/25
- HS Code
- 29349990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H340May cause genetic defects
- Precautionary statements
-
P202Do not handle until all safety precautions have been read and understood.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- PHR2491
- Product name
- Irinotecan Related Compound A
- Purity
- Pharmaceutical Secondary Standard; Certified Reference Material
- Packaging
- 25MG
- Price
- $485
- Updated
- 2024/03/01
- Product number
- 1347610
- Product name
- Irinotecan Related Compound A
- Packaging
- 10mg
- Price
- $1490
- Updated
- 2024/03/01
- Product number
- H1463
- Product name
- 10-Hydroxycamptothecin
- Purity
- >98.0%(HPLC)
- Packaging
- 1g
- Price
- $231
- Updated
- 2024/03/01
- Product number
- 14635
- Product name
- (S)-10-hydroxy-Camptothecin
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $57
- Updated
- 2024/03/01
- Product number
- 14635
- Product name
- (S)-10-hydroxy-Camptothecin
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $107
- Updated
- 2024/03/01
10-Hydroxycamptothecin Chemical Properties,Usage,Production
Description
DNA topoisomerases relax supercoiled DNA during replication, transcription, recombination, repair, and chromosome condensation. The relaxation of DNA supercoiling by topoisomerase I at single-
Chemical Properties
Yellow Solid
Uses
A Camptothecin derivative; a topoisomerase inhibitor for cancer therapy
Definition
ChEBI: 10-Hydroxycamptothecin is a pyranoindolizinoquinoline.
in vitro
10-Hydroxycamptothecin inhibited the growth of BT-20 and MDA-231 cells with IC50 of 34.3nM and 7.27nM, respectively, which was more potent than camptothecin (CPT) with IC50>500nM. 10-Hydroxycamptothecin potently induces the formation of the pBR322 plasmid DNA cleavage complex mediated by human topoisomerase I with an EC50 of 0.35 μM, more than 50-fold more potent than CPT with an EC50 of 18.85 μM. 10-Hydroxycamptothecin treatment caused dose-dependent growth inhibition of human microvascular endothelial cells (HMECs) with IC50 of 0.31 μM and significantly inhibited HMEC migration with IC50 of 0.63 μM. Treatment of HMEC cells with 10-Hydroxycamptothecin also inhibited microtubule formation in a dose-dependent manner with IC50 of 0.96 μM. 10-Hydroxycamptothecin (5-20 nM) significantly inhibits the differentiation of Colo205 cells, arrests the cell cycle in G2 phase, and induces apoptosis through a caspase-3-dependent pathway.
in vivo
In the CAM model, 10-Hydroxycamptothecin treatment inhibited angiogenesis in a concentration-dependent manner, with 95% inhibition at 25 nM, more potent than suramin, which inhibited only 60% of angiogenesis at 125 nM. 10-Hydroxycamptothecin, administered orally at low doses of 2.5-7.5 mg/kg every two days, caused significant growth inhibition in Colo205 xenograft mice, but no acute toxicity. LD50: 104 mg/kg in mice (intraperitoneal injection).
IC 50
0.31 μm
References
[1] vladu b, woynarowski jm, manikumar g, wani mc, wall me, von hoff dd, wadkins rm. 7- and 10-substituted camptothecins: dependence of topoisomerase i-dna cleavable complex formation and stability on the 7- and 10-substituents. mol pharmacol. 2000 feb;57(2):243-51.
[2] xiao d, tan w, li m, ding j. antiangiogenic potential of 10-hydroxycamptothecin. life sci. 2001 aug 24;69(14):1619-28.
[3] ping yh, lee hc, lee jy, wu ph, ho lk, chi cw, lu mf, wang jj. anticancer effects of low-dose 10-hydroxycamptothecin in human colon cancer. oncol rep. 2006 may;15(5):1273-9.
10-Hydroxycamptothecin Preparation Products And Raw materials
Raw materials
Preparation Products
10-Hydroxycamptothecin Suppliers
- Tel
- --
- Fax
- --
- info@specs.net
- Country
- The Netherlands
- ProdList
- 6835
- Advantage
- 70
View Lastest Price from 10-Hydroxycamptothecin manufacturers
- Product
- 10-Hydroxycamptothecin 19685-09-7
- Price
- US $0.00/mg
- Min. Order
- 5mg
- Purity
- ≥98%(HPLC)
- Supply Ability
- 10 g
- Release date
- 2019-11-20
- Product
- 10-Hydroxycamptothecin 19685-09-7
- Price
- US $0.00-0.00/g
- Min. Order
- 1g
- Purity
- ≥98%
- Supply Ability
- 1-10000g
- Release date
- 2022-11-22
- Product
- 10-Hydroxycamptothecin 19685-09-7 19685-09-7
- Price
- US $15.60/mg
- Min. Order
- 20mg
- Purity
- 98.00
- Supply Ability
- 1000.00 kgs
- Release date
- 2019-07-09