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4-(BENZYLOXY)PYRIDINE

Product Name
4-(BENZYLOXY)PYRIDINE
CAS No.
49826-70-2
Chemical Name
4-(BENZYLOXY)PYRIDINE
Synonyms
4-(BENZYLOXY)PYRIDINE;4-BENZYLOXYPYRIDINE(I);4-phenylmethoxypyridine;Pyridine,4-(phenylmethoxy)-;4-[(Phenylmethyl)oxy]pyridine;ETHYL3-(CYANOMETHYL)-2-OXO-2,3-DIHYDRO-1H-BENZO[D]IMIDAZOLE-3-CARBOXYLATE
CBNumber
CB4445829
Molecular Formula
C12H11NO
Formula Weight
185.22
MOL File
49826-70-2.mol
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4-(BENZYLOXY)PYRIDINE Property

Melting point:
57-58℃
Boiling point:
310℃
Density 
1.106
Flash point:
114℃
storage temp. 
Inert atmosphere,Room Temperature
pka
6.58±0.10(Predicted)
Appearance
Off-white to light yellow Solid
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Safety

HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Apolloscientific
Product number
OR942402
Product name
4-(Benzyloxy)pyridine
Purity
95%
Packaging
250mg
Price
$203
Updated
2021/12/16
Apolloscientific
Product number
OR942402
Product name
4-(Benzyloxy)pyridine
Purity
95%
Packaging
1g
Price
$486
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0378179
Product name
4-(BENZYLOXY)PYRIDINE
Purity
95.00%
Packaging
5MG
Price
$503.16
Updated
2021/12/16
AK Scientific
Product number
2549AL
Product name
4-(Benzyloxy)pyridine
Packaging
5g
Price
$840
Updated
2021/12/16
AK Scientific
Product number
2549AL
Product name
4-(Benzyloxy)pyridine
Packaging
10g
Price
$1245
Updated
2021/12/16
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4-(BENZYLOXY)PYRIDINE Chemical Properties,Usage,Production

Synthesis

7379-35-3

100-51-6

49826-70-2

Sodium hydride (60% mineral oil dispersion, 0.72 g, 18.0 mmol) was added to a dry reaction flask, followed by the addition of N,N-dimethylformamide (30 mL) to form a suspension, and the mixture was cooled to 5 °C. Under stirring, benzyl alcohol (1.04 mL, 10.0 mmol) was slowly added dropwise. After dropwise addition, stirring was continued for 15 minutes. Subsequently, 4-chloropyridine hydrochloride (1.00 g, 6.67 mmol) was added in batches, with each addition approximately 5 minutes apart. After the addition was completed, the reaction mixture was stirred at 5°C for 10 minutes, then gradually warmed to 60°C and stirred at this temperature for 1.5 hours. After completion of the reaction, the mixture was cooled to room temperature (23°C), the reaction was quenched by the addition of water and extracted with ethyl acetate. The organic phases were combined, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography with gradient elution of hexane solution with 5% to 50% ethyl acetate as eluent to give the target product 4-benzyloxypyridine (1.10 g, 89% yield).

References

[1] Journal of Organic Chemistry, 2017, vol. 82, # 24, p. 13756 - 13767
[2] Patent: US2011/275627, 2011, A1. Location in patent: Page/Page column 60
[3] Patent: EP2331541, 2011, A1. Location in patent: Paragraph 0070; 0071
[4] Patent: EP2331541, 2015, B1. Location in patent: Paragraph 0070; 0071

4-(BENZYLOXY)PYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-(BENZYLOXY)PYRIDINE Suppliers

China 49 India 1 United Kingdom 2 United States 5 Global 57
Manchester Organics
Tel
--
Fax
--
Email
info@manchesterorganics.com
Country
United Kingdom
ProdList
6834
Advantage
67
Fluorochem Ltd.
Tel
--
Fax
--
Email
enquiries@fluorochem.co.uk
Country
United Kingdom
ProdList
6401
Advantage
74
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View Lastest Price from 4-(BENZYLOXY)PYRIDINE manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
4-(BENZYLOXY)PYRIDINE 49826-70-2
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10000KGS
Release date
2025-07-26
Career Henan Chemical Co
Product
4-phenylmethoxypyridine 49826-70-2
Price
US $9.80/KG
Min. Order
1KG
Purity
≥98%
Supply Ability
20 tons
Release date
2020-01-09

49826-70-2, 4-(BENZYLOXY)PYRIDINERelated Search:

2-PHENYL-2-(PYRIDIN-4-YLOXY)-ETHYLAMINE 4-(Benzyloxy)pyridine N-oxide 3,5-DICHLORO-2,6-DIFLUORO-4-BENZYLOXYPYRIDINE 4-BENZYLOXY-QUINOLIN-2-OL 4-(BENZYLOXY)-2-(CHLOROMETHYL)PYRIDINE Diethyl 4-(phenylmethoxy)-2,6-pyridinedicarboxylate 4-BENZYLOXY-2(1 H)-PYRIDONE Bis(phenylmethyl) 4-(phenylmethoxy)-2,6-pyridinedicarboxylate 4-(BENZYLOXY)PYRIDINE 4-BENZYLOXY-QUINOLINE

  • 4-(BENZYLOXY)PYRIDINE
  • 4-BENZYLOXYPYRIDINE(I)
  • 4-[(Phenylmethyl)oxy]pyridine
  • Pyridine,4-(phenylmethoxy)-
  • 4-phenylmethoxypyridine
  • ETHYL3-(CYANOMETHYL)-2-OXO-2,3-DIHYDRO-1H-BENZO[D]IMIDAZOLE-3-CARBOXYLATE
  • 49826-70-2