2,3-DIFLUORO-5-(TRIFLUOROMETHYL)PYRIDINE
Description Uses- Product Name
- 2,3-DIFLUORO-5-(TRIFLUOROMETHYL)PYRIDINE
- CAS No.
- 89402-42-6
- Chemical Name
- 2,3-DIFLUORO-5-(TRIFLUOROMETHYL)PYRIDINE
- Synonyms
- 2,3-DIFLUORO-5-(TRIFLUOROMETHYL)PYRIDINE;Pyridine, 2,3-difluoro-5-(trifluoromethyl)-;2,3-Difluoro-5-(trifluoromethyl)pyridine >alpha,alpha,alpha,5,6-Pentafluoro-3-picoline
- CBNumber
- CB4449872
- Molecular Formula
- C6H2F5N
- Formula Weight
- 183.08
- MOL File
- 89402-42-6.mol
2,3-DIFLUORO-5-(TRIFLUOROMETHYL)PYRIDINE Property
- Melting point:
- -20°C
- Boiling point:
- 104°C
- Density
- 1,47 g/cm3
- refractive index
- 1.3860-1.3900
- Flash point:
- 28°C
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- clear liquid
- pka
- -5.28±0.20(Predicted)
- color
- Colorless to Light yellow to Light orange
- InChI
- InChI=1S/C6H2F5N/c7-4-1-3(6(9,10)11)2-12-5(4)8/h1-2H
- InChIKey
- XIFCGIKPAAZFFS-UHFFFAOYSA-N
- SMILES
- C1(F)=NC=C(C(F)(F)F)C=C1F
- CAS DataBase Reference
- 89402-42-6(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- D4623
- Product name
- 2,3-Difluoro-5-(trifluoromethyl)pyridine
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $43
- Updated
- 2025/07/31
- Product number
- D4623
- Product name
- 2,3-Difluoro-5-(trifluoromethyl)pyridine
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $123
- Updated
- 2025/07/31
- Product number
- B426285
- Product name
- 2,3-Difluoro-5-(trifluoromethyl)pyridine
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 024995
- Product name
- 2,3-Difluoro-5-(trifluoromethyl)pyridine
- Purity
- 98%
- Packaging
- 5g
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 024995
- Product name
- 2,3-Difluoro-5-(trifluoromethyl)pyridine
- Purity
- 98%
- Packaging
- 1g
- Price
- $20
- Updated
- 2021/12/16
2,3-DIFLUORO-5-(TRIFLUOROMETHYL)PYRIDINE Chemical Properties,Usage,Production
Description
2,3-Difluoro-5-(trifluoromethyl)pyridine is a useful research chemical.
Uses
2,3-Difluoro-5-(trifluoroMethyl)pyridine is a heterocyclic compound and can be used as a pharmaceutical intermediate.
Synthesis
69045-84-7
89402-42-6
The general procedure for the synthesis of 2,3-dichloro-5-trifluoromethylpyridine from 2,3-dichloro-5-trifluoromethylpyridine is as follows: 1500 mL of DMSO, 363 g of cesium fluoride, and 8 g of potassium carbonate were added to a 5000 mL reaction flask and heated in an oil bath. Concentrate and cool 600 mL of DMSO under reduced pressure to below 80 °C. Under nitrogen protection, 318 g (1.58 mol) of 2,3-dichloro-5-trifluoromethylpyridine was added to the reaction system and the reaction was carried out at about 110 °C for 48 hours. After completion of the reaction, 600 mL of water was added to the yellow liquid for liquid-liquid separation. The organic phase was dried with anhydrous magnesium sulfate and filtered to give a crude product of 188 g. The 100-102 °C fractions were collected by distillation to give 139 g of 2,3-difluoro-5-trifluoromethylpyridine in 47.6% yield.
References
[1] Patent: CN104628679, 2018, B. Location in patent: Paragraph 0061; 0064; 0065
[2] Patent: US2008/221327, 2008, A1. Location in patent: Page/Page column 6; 9
2,3-DIFLUORO-5-(TRIFLUOROMETHYL)PYRIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,3-DIFLUORO-5-(TRIFLUOROMETHYL)PYRIDINE manufacturers
- Product
- 2,3-Difluoro-5-(trifluoromethyl)pyridine 89402-42-6
- Price
- US $3.00-9.00/KG
- Min. Order
- 0.009999999776482582KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2025-06-21
- Product
- 2,3-DIFLUORO-5-(TRIFLUOROMETHYL)PYRIDINE 89402-42-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2020-01-03
- Product
- 2,3-DIFLUORO-5-(TRIFLUOROMETHYL)PYRIDINE 89402－42－6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%HPLC
- Supply Ability
- 10t
- Release date
- 2019-12-24