3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE

Product Name: 3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE
CAS No.: 72537-17-8
Chemical Name: 3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE
Synonyms: 2-FLUORO-3-CHLORO-5-(TRIFLUOROMETHYL)PYRIDINE;CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE;3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE;Pyridine, 3-chloro-2-fluoro-5-(trifluoromethyl)-;3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine >3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine 98%;TIANFU-CHEM 3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE;3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE ISO 9001：2015 REACH
CBNumber: CB2145237
Molecular Formula: C6H2ClF4N
Formula Weight: 199.53
MOL File: 72537-17-8.mol

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3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE Property

Melting point:: 16-20 °C (lit.)
Boiling point:: 50-55 °C/11 mmHg (lit.)
Density: 1.524 g/mL at 25 °C (lit.)
refractive index: n20/D 1.433(lit.)
Flash point:: 125 °F
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: Liquid
color: Colorless
InChI: InChI=1S/C6H2ClF4N/c7-4-1-3(6(9,10)11)2-12-5(4)8/h1-2H
InChIKey: GDSROTVTTLUHCO-UHFFFAOYSA-N
SMILES: C1(F)=NC=C(C(F)(F)F)C=C1Cl
CAS DataBase Reference: 72537-17-8(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 10-36/37/38
Safety Statements: 26-36
RIDADR: UN 1993 3/PG 3
WGK Germany: 3
Hazard Note: Irritant
HazardClass: 3.2
PackingGroup: III
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H226Flammable liquid and vapour

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 393576
Product name: 3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine
Purity: 98%
Packaging: 5g
Price: $105
Updated: 2023/01/07

TCI Chemical

Product number: C2671
Product name: 3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine
Purity: >98.0%(GC)
Packaging: 5g
Price: $55
Updated: 2025/07/31

TRC

Product number: C367783
Product name: 3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine
Packaging: 100mg
Price: $60
Updated: 2021/12/16

Matrix Scientific

Product number: 018282
Product name: 3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine
Purity: 97%
Packaging: 25g
Price: $62
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H32-7-08
Product name: 3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine
Purity: 97%
Packaging: 5G
Price: $65
Updated: 2021/12/16

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3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE Chemical Properties,Usage,Production

General Description

3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine, a halogenated pyridine derivative, is a fluorinated building block. It participates in the synthesis of 2,3-difluoro-5-(trifluoromethyl)pyridine.

Synthesis

69045-84-7

72537-17-8

The general procedure for the synthesis of 3-chloro-2-fluoro-5-(trifluoromethyl)pyridine from 2,3-dichloro-5-trifluoromethylpyridine is as follows: Example 3b. Equipment: 250 mL four-necked round-bottomed flask equipped with a thermometer, mechanical stirrer, dropping funnel and inert gas inlet. Operating steps: 1. 25 mL of DMSO was added to a 250 mL four-necked round-bottomed flask, and the solvent was evaporated from a suspension of 150 mL of DMSO, 2.5 g of potassium carbonate (17.9 mmol), and 25.0 g of cesium fluoride (162.9 mmol) at 120 °C and 25-30 mbar pressure. 2. 25.0 g of 2,3-dichloro-5-trifluoromethylpyridine (112.3 mmol) was added to the reaction mixture and the reaction was stirred at 120 °C for 4 hours. 3. After completion of the reaction, the suspension was filtered and the product 3-chloro-2-fluoro-5-(trifluoromethyl)pyridine was distilled directly from the distillate at 95 to 115 °C and 40-60 mbar pressure to obtain the product in quantitative yield. PRODUCT ANALYSIS: GC analysis showed a product purity of 96.9 area percent.

References

[1] Patent: US2008/221327, 2008, A1. Location in patent: Page/Page column 9-10
[2] Patent: US2008/221327, 2008, A1. Location in patent: Page/Page column 6
[3] Patent: CN107286087, 2017, A. Location in patent: Paragraph 0032; 0033
[4] Patent: CN106905231, 2017, A. Location in patent: Paragraph 0077; 0078; 0079; 0080; 0081; 0082; 0083-0085
[5] Patent: EP1199305, 2002, A1. Location in patent: Page 6

3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE Suppliers

Americas 1 China 154 Europe 1 Germany 7 India 2 Japan 1 Switzerland 3 United Kingdom 14 United States 28 Global 211

Dexin chemical (Shandong) Co. , Ltd.

Tel: 18815338815
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J & K SCIENTIFIC LTD.

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Alfa Aesar

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TCI (Shanghai) Development Co., Ltd.

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Shijiazhuang Sdyano Fine Chemical Co., Ltd.

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Wuhan Chemwish Technology Co., Ltd

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Beijing Ouhe Technology Co., Ltd

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View Lastest Price from 3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE manufacturers

Shandong Jihui Chemical Co., Ltd.

Product: 2-Fluoro-3-chloro-5-(trifluoromethyl)pyridine 72537-17-8
Price: US $0.00-0.00/KG
Min. Order: 250KG
Purity: Purity: 99%
Supply Ability: 1000tons
Release date: 2025-07-20

Dideu Industries Group Limited

Product: 3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE 72537-17-8
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-10-27

Career Henan Chemical Co

Product: 3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE 72537-17-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1kg,5kg,100kg
Release date: 2019-07-04

72537-17-8, 3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINERelated Search:

Picoxystrobin 2-Cyano-3,5-difluoropyridine 2,3-DIFLUORO-5-(TRIFLUOROMETHYL)PYRIDINE 3-Chloro-2-fluorobenzotrifluoride 2-Amino-3-fluoro-5-(trifluoromethyl)pyridine 2,3-DIFLUOROBENZOTRIFLUORIDE 3-Chloro-5-(trifluoromethyl)pyridine 2-Chloro-3-fluoro-6-(trifluoromethyl)pyridine 2-CHLORO-3-FLUORO-4-(TRIFLUOROMETHYL)PYRIDINE 2-Chloro-5-fluoro-3-(trifluoromethyl)pyridine 5-Chloro-2-fluoro-3-(trifluoromethyl)pyridine 3-Chloro-2-fluoro-pyridine 3-Chloro-2-fluoro-5-methylpyridine 2-Fluoro-5-methylpyridine 2-Fluoro-5-trifluoromethylpyridine 3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE

3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE

2-FLUORO-3-CHLORO-5-(TRIFLUOROMETHYL)PYRIDINE

CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE

3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine 98%

3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine &gt

Pyridine, 3-chloro-2-fluoro-5-(trifluoromethyl)-

3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE ISO 9001：2015 REACH

TIANFU-CHEM 3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE

72537-17-8

71537-17-8

C6H2ClF4N

Building Blocks

Halogenated Heterocycles

Heterocyclic Building Blocks

Pyridines

Halogenated Heterocycles

Heterocyclic Building Blocks

Pyridines, Pyrimidines, Purines and Pteredines

Halides

Pyridines

C6Heterocyclic Building Blocks