2-Fluoro-5-methylpyridine

Product Name: 2-Fluoro-5-methylpyridine
CAS No.: 2369-19-9
Chemical Name: 2-Fluoro-5-methylpyridine
Synonyms: 2-Fluoro-5-m;uoro-5-methyL;6-FLUORO-3-PICOLINE;2-FLUORO-5-PICOLINE;Fluoromethylpyridine3;2-FLUORO-5-METHYPYRIDINE;2-Bromo-1-methylpyridine;2-FLUORO-5-METHYLPYRIDINE;2-Fluoro-5-methylpyridine97%;2-Fluoro-5-methylpyridine>
CBNumber: CB3742934
Molecular Formula: C6H6FN
Formula Weight: 111.12
MOL File: 2369-19-9.mol

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2-Fluoro-5-methylpyridine Property

Boiling point:: 158-159 °C (lit.)
Density: 1.072 g/mL at 25 °C (lit.)
refractive index: n20/D 1.4730(lit.)
Flash point:: 119 °F
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: -0.14±0.10(Predicted)
form: Liquid
Specific Gravity: 1.077
color: Colorless to pale yellow
BRN: 107085
InChI: InChI=1S/C6H6FN/c1-5-2-3-6(7)8-4-5/h2-4H,1H3
InChIKey: AOSOZARHUJMBLZ-UHFFFAOYSA-N
SMILES: C1(F)=NC=C(C)C=C1
CAS DataBase Reference: 2369-19-9(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,F
Risk Statements: 10-36/37/38
Safety Statements: 16-26-36/37-36
RIDADR: UN 1993 3/PG 3
WGK Germany: 3
Hazard Note: Flammable/Irritant
HazardClass: 3
PackingGroup: III
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H226Flammable liquid and vapour

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 595136
Product name: 2-Fluoro-5-methylpyridine
Purity: 97%
Packaging: 1g
Price: $44.4
Updated: 2023/06/20

TCI Chemical

Product number: F0581
Product name: 2-Fluoro-5-methylpyridine
Purity: >98.0%(GC)
Packaging: 1g
Price: $30
Updated: 2025/07/31

TCI Chemical

Product number: F0581
Product name: 2-Fluoro-5-methylpyridine
Purity: >98.0%(GC)
Packaging: 5g
Price: $87
Updated: 2025/07/31

TRC

Product number: F600073
Product name: 2-Fluoro-5-methylpyridine
Packaging: 2.5g
Price: $45
Updated: 2021/12/16

TRC

Product number: F600073
Product name: 2-Fluoro-5-methylpyridine
Packaging: 5g
Price: $60
Updated: 2021/12/16

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2-Fluoro-5-methylpyridine Chemical Properties,Usage,Production

Chemical Properties

liquid

Synthesis

1603-41-4

2369-19-9

To a solution of 2-amino-5-methylpyridine (13) (20.0 g, 185 mmol) in fluoboric acid (50 wt% aqueous solution, 50 mL) was added sodium nitrite (16.6 g, 240 mmol) in batches at -10 °C while controlling the temperature of the reaction to be below 0 °C. After addition, the reaction mixture was stirred at 0 °C for 30 min, then warmed to 50 °C and continued stirring for 30 min. After completion of the reaction, the reaction was cooled to room temperature and the pH was adjusted to 9-10 with saturated aqueous sodium carbonate solution (250 mL), followed by extraction with dichloromethane (4 x 125 mL). The organic phases were combined, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by alumina column chromatography (eluent: dichloromethane) to afford 2-fluoro-5-methylpyridine (14) (7.50 g, 69 mmol) as a yellow oil in 37% yield. Thin-layer chromatography (TLC) analysis: Rf (Al2O3, dichloromethane) 0.92. Infrared spectra (IR, NaCl plate) νmax: 1246, 1379, 1486, 2929 cm-1. nuclear magnetic resonance hydrogen spectra (1H NMR, 200 MHz, CDCl3) δ: 2.25 (s, 3H, CH3), 6.75 (dd, 1H, J = 8.2 Hz, 3JH-F = 3.0 Hz, H-3), 7.52 (m, 1H, H-4), 7.94 (s, 1H, H-6). Nuclear magnetic resonance carbon spectrum (13C NMR, 50 MHz, CDCl3) δ: 17.4 (CH3), 108.8 (d, 2JC-F = 38Hz, C-3), 130.6 (C-5), 141.7 (d, 3JC-F = 8Hz, C-4), 147.2 (d, 3JC-F = 14Hz, C-6), 162.1 (d. 1JC-F = 236Hz, C-2).

References

[1] Journal of Fluorine Chemistry, 2005, vol. 126, # 3, p. 345 - 348
[2] European Journal of Medicinal Chemistry, 2015, vol. 92, p. 818 - 838
[3] Journal of the American Chemical Society, 1949, vol. 71, p. 1125
[4] Journal of Medicinal Chemistry, 1990, vol. 33, # 6, p. 1667 - 1675
[5] Patent: US5583148, 1996, A

2-Fluoro-5-methylpyridine Preparation Products And Raw materials

Raw materials

2-Amino-5-methylpyridine Sodium nitrite Fluoroboric acid

Preparation Products

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2-Fluoro-5-methylpyridine Suppliers

Americas 1 China 269 Europe 3 France 1 Germany 6 India 15 Italy 1 Japan 2 Switzerland 2 Ukraine 1 United Kingdom 17 United States 43 Global 361

Shanghai Longsheng chemical Co.,Ltd.

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View Lastest Price from 2-Fluoro-5-methylpyridine manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 2-Fluoro-5-methylpyridine 2369-19-9
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-05-30

Henan Aochuang Chemical Co.,Ltd.

Product: 2-Fluoro-5-methylpyridine 2369-19-9
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-09-29

Henan Fengda Chemical Co., Ltd

Product: 2-Fluoro-5-methylpyridine 2369-19-9
Price: US $5.00-0.10/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-08

2369-19-9, 2-Fluoro-5-methylpyridineRelated Search:

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uoro-5-methyL

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2-Fluoro-5-methylpyridine ISO 9001：2015 REACH

2369-19-9

369-19-9

C6H6NF

Building Blocks

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