3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE
- Product Name
- 3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE
- CAS No.
- 72537-17-8
- Chemical Name
- 3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE
- Synonyms
- 2-FLUORO-3-CHLORO-5-(TRIFLUOROMETHYL)PYRIDINE;CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE;3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE;Pyridine, 3-chloro-2-fluoro-5-(trifluoromethyl)-;3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine >3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine 98%;TIANFU-CHEM 3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE;3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE ISO 9001：2015 REACH
- CBNumber
- CB2145237
- Molecular Formula
- C6H2ClF4N
- Formula Weight
- 199.53
- MOL File
- 72537-17-8.mol
3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE Property
- Melting point:
- 16-20 °C (lit.)
- Boiling point:
- 50-55 °C/11 mmHg (lit.)
- Density
- 1.524 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.433(lit.)
- Flash point:
- 125 °F
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- Liquid
- color
- Colorless
- InChI
- InChI=1S/C6H2ClF4N/c7-4-1-3(6(9,10)11)2-12-5(4)8/h1-2H
- InChIKey
- GDSROTVTTLUHCO-UHFFFAOYSA-N
- SMILES
- C1(F)=NC=C(C(F)(F)F)C=C1Cl
- CAS DataBase Reference
- 72537-17-8(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 10-36/37/38
- Safety Statements
- 26-36
- RIDADR
- UN 1993 3/PG 3
- WGK Germany
- 3
- Hazard Note
- Irritant
- HazardClass
- 3.2
- PackingGroup
- III
- HS Code
- 29333990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H226Flammable liquid and vapour
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 393576
- Product name
- 3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine
- Purity
- 98%
- Packaging
- 5g
- Price
- $105
- Updated
- 2023/01/07
- Product number
- C2671
- Product name
- 3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $55
- Updated
- 2025/07/31
- Product number
- C367783
- Product name
- 3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 018282
- Product name
- 3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine
- Purity
- 97%
- Packaging
- 1g
- Price
- $11
- Updated
- 2021/12/16
- Product number
- J56141
- Product name
- 3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine
- Packaging
- 1g
- Price
- $14
- Updated
- 2021/12/16
3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE Chemical Properties,Usage,Production
General Description
3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine, a halogenated pyridine derivative, is a fluorinated building block. It participates in the synthesis of 2,3-difluoro-5-(trifluoromethyl)pyridine.
Synthesis
69045-84-7
72537-17-8
The general procedure for the synthesis of 3-chloro-2-fluoro-5-(trifluoromethyl)pyridine from 2,3-dichloro-5-trifluoromethylpyridine is as follows: Example 3b. Equipment: 250 mL four-necked round-bottomed flask equipped with a thermometer, mechanical stirrer, dropping funnel and inert gas inlet. Operating steps: 1. 25 mL of DMSO was added to a 250 mL four-necked round-bottomed flask, and the solvent was evaporated from a suspension of 150 mL of DMSO, 2.5 g of potassium carbonate (17.9 mmol), and 25.0 g of cesium fluoride (162.9 mmol) at 120 °C and 25-30 mbar pressure. 2. 25.0 g of 2,3-dichloro-5-trifluoromethylpyridine (112.3 mmol) was added to the reaction mixture and the reaction was stirred at 120 °C for 4 hours. 3. After completion of the reaction, the suspension was filtered and the product 3-chloro-2-fluoro-5-(trifluoromethyl)pyridine was distilled directly from the distillate at 95 to 115 °C and 40-60 mbar pressure to obtain the product in quantitative yield. PRODUCT ANALYSIS: GC analysis showed a product purity of 96.9 area percent.
References
[1] Patent: US2008/221327, 2008, A1. Location in patent: Page/Page column 9-10
[2] Patent: US2008/221327, 2008, A1. Location in patent: Page/Page column 6
[3] Patent: CN107286087, 2017, A. Location in patent: Paragraph 0032; 0033
[4] Patent: CN106905231, 2017, A. Location in patent: Paragraph 0077; 0078; 0079; 0080; 0081; 0082; 0083-0085
[5] Patent: EP1199305, 2002, A1. Location in patent: Page 6
3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE Suppliers
- Tel
- 800-4238616
- Fax
- +1-888-520-1075 / +1-503-283-1987
- sales@tciamerica.com
- Country
- Americas
- ProdList
- 23653
- Advantage
- 75
View Lastest Price from 3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE manufacturers
- Product
- 2-Fluoro-3-chloro-5-(trifluoromethyl)pyridine 72537-17-8
- Price
- US $0.00-0.00/KG
- Min. Order
- 250KG
- Purity
- Purity: 99%
- Supply Ability
- 1000tons
- Release date
- 2025-07-20
- Product
- 3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE 72537-17-8
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-10-27
- Product
- 3-CHLORO-2-FLUORO-5-(TRIFLUOROMETHYL)PYRIDINE 72537-17-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1kg,5kg,100kg
- Release date
- 2019-07-04