D(+)-Trehalose dihydrate
- Product Name
- D(+)-Trehalose dihydrate
- CAS No.
- 6138-23-4
- Chemical Name
- D(+)-Trehalose dihydrate
- Synonyms
- TREHALOSE DIHYDRATE;D-TREHALOSE;D-TREHALOSE DIHYDRATE;Trehalose (hydrate);ALPHA-D-GLUCOPYRANOSYL-ALPHA-D-GLUCOPYRANOSIDE DIHYDRATE;Haizaotang;Trehalose 99;D-(+)-TrehaL;ose dihydrate;Trehalose2H2O
- CBNumber
- CB4454890
- Molecular Formula
- C12H22O11·2H2O
- Formula Weight
- 378.33
- MOL File
- 6138-23-4.mol
D(+)-Trehalose dihydrate Property
- Melting point:
- 97-99 °C(lit.)
- alpha
- 179 º (c=2, H2O)
- Boiling point:
- 115.3 °C
- refractive index
- 181 ° (C=7, H2O)
- FEMA
- 4600 | TREHALOSE, DIHYDRATE
- storage temp.
- room temp
- solubility
- H2O: 50 mg/mL
- form
- powder
- color
- White to Off-White
- optical activity
- [α]20/D +179±3°, c = 2% in H2O
- Water Solubility
- 68.9 g/100 mL (20 ºC)
- Sensitive
- Hygroscopic
- Merck
- 14,9580
- BRN
- 5322018
- InChIKey
- DPVHGFAJLZWDOC-NYAOJISMSA-N
- CAS DataBase Reference
- 6138-23-4(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 38-36/37/38
- Safety Statements
- 37/39-26-24/25
- WGK Germany
- 2
- RTECS
- LZ5776547
- F
- 3-10
- TSCA
- Yes
- HS Code
- 29400000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 90210
- Product name
- D-(+)-Trehalose dihydrate
- Purity
- for microbiology, ≥99.0%
- Packaging
- 50g
- Price
- $241
- Updated
- 2024/03/01
- Product number
- 625625
- Product name
- Trehalose, Dihydrate - CAS 6138-23-4 - Calbiochem
- Purity
- Non-reducingdisaccharidewhichyields2molesofD-glucoseuponacidhydrolysis
- Packaging
- 50g
- Price
- $112
- Updated
- 2024/03/01
- Product number
- 1673715
- Product name
- Trehalose
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 400mg
- Price
- $491
- Updated
- 2024/03/01
- Product number
- 1.02776
- Product name
- Trehalose dihydrate
- Purity
- EMPROVE? EXPERT, Ph. Eur., ChP, NF, JP
- Packaging
- 1KG
- Price
- $1086
- Updated
- 2024/03/01
- Product number
- 1.02776
- Product name
- Trehalose dihydrate
- Purity
- EMPROVE? EXPERT, Ph. Eur., ChP, NF, JP
- Packaging
- 12KG
- Price
- $7273
- Updated
- 2024/03/01
D(+)-Trehalose dihydrate Chemical Properties,Usage,Production
Description
Trehalose is a natural non-reducing disaccharide composed of two α-glucose units. It is found in all major groups of organisms except vertebrates, has biological functions as an osmolyte, storage reserve, and stress protectant, and has diverse commercial applications. Trehalose can also induce or enhance autophagy.
Chemical Properties
D(+)-Trehalose dihydrate occurs as virtually odorless, white or almost white crystals with a sweet taste (approximately 45% of the sweetness of sucrose).
Uses
Stabilizes cells during freezing, freeze-drying and air-drying. Sweetener and stabilizer in foods; cryoprotectant for freeze-dried foods. Additive in cosmetics and personal care products.
Uses
D(+)-Trehalose dihydrate is used in many processed foods as well as in biopharmaceutical monoclonal antibody formulations, it is also used as a protein stabilize.
Production Methods
Trehalose is prepared from liquefied starch by a multistep enzymatic process. The commercial product is the dihydrate.
Pharmaceutical Applications
D(+)-Trehalose dihydrate is used for the lyoprotection of therapeutic proteins, particularly for parenteral administration. Other pharmaceutically relevant applications include use as an excipient for diagnostic assay tablets; for stabilization during the freeze–thaw and lyophilization of liposomes; and for stabilization of blood cells, cosmetics, and monoclonal antibodies. Trehalose may also be used in formulations for topical application.
Biochem/physiol Actions
D(+)-Trehalose dihydrate is a non-reducing sugar formed from two glucose units joined by a 1-1 alpha bond. It is thought to provide plants and animals with the ability to withstanding periods of dehydration.
Safety
Trehalose is used in cosmetics, foods, and parenteral and
nonparenteral pharmaceutical formulations. It is generally regarded
as a relatively nontoxic and nonirritant material when used as an
excipient.
In the gut, trehalose is rapidly metabolized to glucose by the
specific enzyme trehalase. A small minority of the population
exhibits a primary (hereditary) or secondary (acquired) trehalase
deficiency and thus may experience intestinal discomfort after
ingestion of excessive amounts of trehalose owing to the osmotic
activity of undigested trehalose in the gut. However, smaller
amounts of trehalose are tolerated by such individuals without
any symptoms.
Trehalose is used as a sweetener and is reported to have
substantially less cariogenic potential than sucrose.
LD50 (dog, IV): >1 g/kg
LD50 (dog, oral): >5 g/kg
LD50 (mouse, IV): >1 g/kg
LD50 (mouse, oral): >5 g/kg
LD50 (rat, IV): >1 g/kg
LD50 (rat, oral): >5 g/kg
storage
Trehalose is a relatively stable material. At 60°C for 5 hours it loses
not more than 1.5% w/w of water (the dihydrate water of crystallization is retained). Open stored powder may liquefy at high
relative humidity (≥90%).
Trehalose should be stored in a cool, dry place in a well-sealed
container.
Purification Methods
α,α-D(+)-Trehalose crystallises (as the dihydrate) from aqueous EtOH. Dry it at 13o. For the anhydrous compound dissolve 10g in pyridine (200mL) and distil off this solvent at atmospheric pressure, and when the temperature rises to 115.3o all the H2O is removed and 73mL of distillate is collected. Most of the anhydrous material crystallises out at this stage. The crystals are collected (6.8g), washed with Et2O to give 6.1g of anhydrous product. Higher yields are obtained by slightly more prolonged distillation. [Birch J Chem Soc 3489 1965, X-ray cryst: Brown et al. Acta Cryst 28 3145 1972, Beilstein 17/8 V 3.]
Incompatibilities
D(+)-Trehalose dihydrate is incompatible with strong oxidizing agents, especially in the presence of heat.
Regulatory Status
GRAS listed. In the UK trehalose may be used in certain food applications. Included in parenteral and nonparenteral investigational formulations.
D(+)-Trehalose dihydrate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from D(+)-Trehalose dihydrate manufacturers
- Product
- D (+) -Trehalose Dihydrate 6138-23-4
- Price
- US $75.00-20.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20ton
- Release date
- 2024-05-29
- Product
- D(+)-Trehalose dihydrate 6138-23-4
- Price
- US $999.00-666.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 5000
- Release date
- 2024-08-13
- Product
- D(+)-Trehalose dihydrate 6138-23-4
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 500kg/month
- Release date
- 2023-01-05