ETHYL THIAZOLE-4-CARBOXYLATE
- Product Name
- ETHYL THIAZOLE-4-CARBOXYLATE
- CAS No.
- 14527-43-6
- Chemical Name
- ETHYL THIAZOLE-4-CARBOXYLATE
- Synonyms
- 4-ThiazoL;4-Ethoxycarbonylthiazole;Ethyl 4-Thiazolecarboxylate;ETHYL THIAZOLE-4-CARBOXYLATE;4-(Ethoxycarbonyl)-1,3-thiazole;ETHYL 1,3-THIAZOLE-4-CARBOXYLATE;2-ethyl-1,3-thiazole-4-carboxylate;Ethyl 1,3-thiazole-4-carboxylate 98%;4-Thiazolecarboxylic Acid Ethyl Ester;Ethyl thiazole-
4- carboxylate - CBNumber
- CB4459305
- Molecular Formula
- C6H7NO2S
- Formula Weight
- 157.19
- MOL File
- 14527-43-6.mol
ETHYL THIAZOLE-4-CARBOXYLATE Property
- Melting point:
- 42-44
- Boiling point:
- 130°C 12mm
- Density
- 1.242±0.06 g/cm3(Predicted)
- Flash point:
- >110℃
- storage temp.
- 2-8°C
- solubility
- Chloroform, Dichloromethane, Ether, Ethyl Acetate
- form
- Solid
- pka
- 0.38±0.10(Predicted)
- color
- Pale-Yellow Crystalline
- CAS DataBase Reference
- 14527-43-6(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 707112
- Product name
- Ethyl 4-thiazolecarboxylate
- Purity
- 97%
- Packaging
- 500mg
- Price
- $33.1
- Updated
- 2023/06/20
- Product number
- E926700
- Product name
- Ethyl 4-thiazolecarboxylate
- Packaging
- 1g
- Price
- $140
- Updated
- 2021/12/16
- Product number
- E926700
- Product name
- Ethyl 4-thiazolecarboxylate
- Packaging
- 10g
- Price
- $1100
- Updated
- 2021/12/16
- Product number
- P000185766
- Product name
- Ethyl thiazole-4-carboxylate
- Purity
- 97%
- Packaging
- 1g
- Price
- $9
- Updated
- 2021/12/16
- Product number
- 8H23-1-X3
- Product name
- Ethyl 1,3-thiazole-4-carboxylate
- Purity
- 97%
- Packaging
- 1g
- Price
- $35
- Updated
- 2021/12/16
ETHYL THIAZOLE-4-CARBOXYLATE Chemical Properties,Usage,Production
Chemical Properties
Pale-Yellow Crystalline Solid
Uses
Ethyl 4-Thiazolecarboxylate (cas# 14527-43-6) is a compound useful in organic synthesis.
Synthesis Reference(s)
Synthesis, p. 681, 1976 DOI: 10.1055/s-1976-24156
Synthesis
3973-08-8
64-17-5
14527-43-6
The general procedure for the synthesis of ethyl 4-thiazolecarboxylate from thiazole-4-carboxylic acid and ethanol was as follows: 2.5 mmol of thiazole-4-carboxylic acid and 2.0 mmol of ethanol were dissolved in 25 mL of dry dichloromethane (DCM) in a dry flask with continuous stirring. Subsequently, 2.5 mmol of 3-(3-dimethylaminopropyl)-1-ethylcarbodiimide hydrochloride (EDC-HCl) was added. After the temperature of the reaction system was lowered to 0 °C, 0.2 mmol of 4-dimethylaminopyridine (DMAP) was added slowly dropwise and the reaction was continued at 0 °C. After completion of the reaction, the temperature of the system was raised to room temperature and the reaction was continued with stirring for 4 hours. Upon termination of the reaction, 25 mL of saturated sodium bicarbonate (NaHCO3) solution was added and extracted twice with dichloromethane (2 x 20 mL). The organic layers were combined, dried with anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure to give the crude product. Finally, the crude product was purified by column chromatography (eluent ratio: ethyl acetate:petroleum ether=1:5) to obtain the target compound ethyl 4-thiazolecarboxylate.
References
[1] European Journal of Medicinal Chemistry, 2018, vol. 145, p. 64 - 73
ETHYL THIAZOLE-4-CARBOXYLATE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from ETHYL THIAZOLE-4-CARBOXYLATE manufacturers
- Product
- ETHYL THIAZOLE-4-CARBOXYLATE 14527-43-6
- Price
- US $8.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2018-12-15