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N6-CYCLOHEXYLADENOSINE

Product Name
N6-CYCLOHEXYLADENOSINE
CAS No.
36396-99-3
Chemical Name
N6-CYCLOHEXYLADENOSINE
Synonyms
CHA;Cyclohexyladenosine;N-Cyclohexyladenosine;N6-CYCLOHEXYLADENOSINE;Adenosine, N-cyclohexyl-;N6-Cyclohexyladenosine,CHA;N(sup 6)-cyclohexyladenosine;(2R,4S)-4-fluoropyrrolidine-6-carboxylicacid;N6-CYCLOHEXYLADENOSINE (CHA) SELECTIVE A 1 ADENOSIN;(2R,3R,4S,5R)-2-(6-(CyclohexylaMino)-9H-purin-9-yl)-5-(hydroxyMethyl)tetrahydrofuran-3,4-diol
CBNumber
CB4468462
Molecular Formula
C16H23N5O4
Formula Weight
349.38
MOL File
36396-99-3.mol
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N6-CYCLOHEXYLADENOSINE Property

Melting point:
182 - 184°C
Boiling point:
675.2±65.0 °C(Predicted)
Density 
1.71±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly)
form 
Solid
pka
13.12±0.70(Predicted)
color 
White to Off-White
Stability:
Hygroscopic
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Safety

WGK Germany 
3
HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
28427
Product name
N6-Cyclohexyladenosine
Packaging
50mg
Price
$96
Updated
2024/03/01
Cayman Chemical
Product number
28427
Product name
N6-Cyclohexyladenosine
Packaging
100mg
Price
$180
Updated
2024/03/01
Cayman Chemical
Product number
28427
Product name
N6-Cyclohexyladenosine
Packaging
25mg
Price
$62
Updated
2024/03/01
Tocris
Product number
6863
Product name
N6-Cyclohexyladenosine
Purity
≥98%(HPLC)
Packaging
50
Price
$85
Updated
2021/12/16
TRC
Product number
C989785
Product name
N6-Cyclohexyladenosine
Packaging
500mg
Price
$745
Updated
2021/12/16
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N6-CYCLOHEXYLADENOSINE Chemical Properties,Usage,Production

Description

N6-Cyclohexyladenosine is an adenosine receptor agonist. It selectively binds to adenosine A1 receptors in rat cortical membranes (IC50 = 2.3 nM) over A2 receptors in rat striatal membranes (IC50 = 870 nM). N6-Cyclohexyladenosine decreases heart rate and increases coronary flow in a perfused working rat heart model ex vivo (EC25s = 5 and 860 nM, respectively). In vivo, it decreases heart rate and blood pressure in normotensive rats (EC25s = 2.4 and 4.2 μg/kg, respectively). N6-Cyclohexyladenosine (100 μM) induces sleep in rats when administered via basal forebrain infusion. N6-Cyclohexyladenosine also decreases locomotor activity in mice (ED50 = 60 μg/kg, i.p.).

Uses

N6-Cyclohexyladenosine is a derivative of Adenosine (A280400), and is used testing adenosine A1 and A2A receptor activation for pharmaceuticals such as antidepressants. N6-Cyclohexyladenosine also is used as a JAK2 inhibitor, blocking STAT3 signalling in human cancer cells.

Biochem/physiol Actions

Selective A1 adenosine receptor agonist.

storage

Store at -20°C

N6-CYCLOHEXYLADENOSINE Preparation Products And Raw materials

Raw materials

Preparation Products

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N6-CYCLOHEXYLADENOSINE Suppliers

China 40 Germany 1 India 1 Russia 1 Switzerland 1 United Kingdom 1 United States 10 Global 55
Nanjing Chemlin Chemical Co., Ltd
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36396-99-3, N6-CYCLOHEXYLADENOSINERelated Search:

Tetramethylthiuram Disulfide Vulcanization accelerator 2',3'-dideoxy-N(6)-cyclohexyladenosine ferritin-cyclohexyladenosine N-ALLYL-N-CYCLOHEXYLADENOSINE N(6)-allyl-N(6)-cyclohexyladenosine (2S)-N6-[2-ENDO-NORBORNYL]ADENOSINE N6-METHYL-2'-DEOXY-ADENOSINE SDZWAG994 CYCLOHEXYLADENOSINE, N6-[ADENINE-2,8-3H]-,N 6-CYCLOHEXYLADENOSINE-[2,8-3H] 6-(METHYLAMINO)PURINE 6-METHYLAMINOPURINE 9-RIBOFURANOSIDE 6-N-HEXYLAMINOPURINE N6-CYCLOHEXYLADENOSINE

  • CHA
  • N6-CYCLOHEXYLADENOSINE
  • N6-CYCLOHEXYLADENOSINE (CHA) SELECTIVE A 1 ADENOSIN
  • N(sup 6)-cyclohexyladenosine
  • Cyclohexyladenosine
  • N-Cyclohexyladenosine
  • Adenosine, N-cyclohexyl-
  • N6-Cyclohexyladenosine,CHA
  • (2R,3R,4S,5R)-2-(6-(CyclohexylaMino)-9H-purin-9-yl)-5-(hydroxyMethyl)tetrahydrofuran-3,4-diol
  • (2R,4S)-4-fluoropyrrolidine-6-carboxylicacid
  • N-6-Cyclohexyladenosine,inhibit,Inhibitor,N6Cyclohexyladenosine,Adenosine Receptor,N6-Cyclohexyladenosine,N6 Cyclohexyladenosine,P1 receptor
  • 36396-99-3