6-(METHYLAMINO)PURINE

Product Name: 6-(METHYLAMINO)PURINE
CAS No.: 443-72-1
Chemical Name: 6-(METHYLAMINO)PURINE
Synonyms: N6-METHYLADENINE;N-Methyl-9H-purin-6-amine;6-Methyladenine;N-methyl-7H-purin-6-amine;N-METHYLADENINE;N6-Methylademine;Adenine, N-methyl-;N6-Monomethyladenine;N(Sup6)-Methyladenine;6-(METHYLAMINO)PURINE
CBNumber: CB1165746
Molecular Formula: C6H7N5
Formula Weight: 149.15
MOL File: 443-72-1.mol

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6-(METHYLAMINO)PURINE Property

Melting point:: ≥300 °C
Boiling point:: 256.3±50.0 °C(Predicted)
Density: 1.57±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: DMSO (Slightly, Heated), Methanol (Slightly, Heated)
form: Solid
pka: 9.61±0.20(Predicted)
color: White to Light Grey
CAS DataBase Reference: 443-72-1

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Safety

WGK Germany: 3
F: 10-23
HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TCI Chemical

Product number: M3166
Product name: N-Methyl-7H-purin-6-amine
Packaging: 1G
Price: $148
Updated: 2025/07/31

Cayman Chemical

Product number: 18153
Product name: N6-Methyladenine
Purity: ≥98%
Packaging: 50mg
Price: $49
Updated: 2024/03/01

Cayman Chemical

Product number: 18153
Product name: N6-Methyladenine
Purity: ≥98%
Packaging: 100mg
Price: $87
Updated: 2024/03/01

Cayman Chemical

Product number: 18153
Product name: N6-Methyladenine
Purity: ≥98%
Packaging: 250mg
Price: $190
Updated: 2024/03/01

Cayman Chemical

Product number: 18153
Product name: N6-Methyladenine
Purity: ≥98%
Packaging: 500mg
Price: $286
Updated: 2024/03/01

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6-(METHYLAMINO)PURINE Chemical Properties,Usage,Production

Uses

N6-Methyladenine is a modified purine that is commonly found in genomes of prokaryotes, protists, and plants. It is less common in higher eukaryotes and extremely rare in mammals. Like methylation of other DNA residues, N6-methyladenine represents an epigenetic modification that can affect diverse DNA functions, including replication, repair, and expression.

Uses

6-(Methylamino)purine, 6-methylade is a reagent for substitution of adenine nucleotide analogs containing bicyclohexane ring system locked in northern conformation enhanced potency as py receptor antagonists. Adenine methylation as an epigenic mark has been observed in single-celled organisms and also rarely in mamalian cells.

Definition

ChEBI: A 6-alkylaminopurine that is 9H-purin-6-amine substituted by a methyl group at the amino nitrogen.

Synthesis

87-42-3

74-89-5

443-72-1

Example 147 Steps for the synthesis of 1-[4-(6-(methylamino)purin-9-yl)phenyl]-3-[3-(4-methylpiperazin-1-ylmethyl)-5-(trifluoromethyl)phenyl]urea (Table 2, compound 25): Step A Preparation of 6-methylaminopurine Dissolve 12.5 g (79 mmol) of 6-chloropurine in 20 mL of 40% methanol solution of methylamine and 20 mL of ethanol. The reaction solution was sealed in a reaction tube and stirred at 120 °C for 4 hours. After completion of the reaction, the reaction solution was concentrated, ground with water, filtered to collect the solid, washed with water and dried under vacuum to give 10.78 g (90% yield) of 6-methylaminopurine as a white solid. 1H-NMR (270 MHz, DMSO-d6) δ (ppm): 2.98 (3H, br.s), 7.58 (1H, br.s), 8.06 (1H, s), 8.19 (1H, br.s), 12.89 (1H, br.s). ESI (LC-MS positive mode) m/z 150 (M + H).

IC 50

Human Endogenous Metabolite

Purification Methods

The purine is best purified by recrystallising 2g from 50mL of H2O and 1.2g of charcoal. [UV: Albert & Brown J Chem Soc 2060 1954; UV: Mason J Chem Soc 2071 1954; see also Elion et al. J Am Chem Soc 74 411 1952.] The picrate has m 265o(257o) [Bredereck et al. Chem Ber 81 307 1948]. [Beilstein 26 III/IV 3565.]

References

[1] Patent: EP1724258, 2006, A1. Location in patent: Page/Page column 138

6-(METHYLAMINO)PURINE Preparation Products And Raw materials

Raw materials

Preparation Products

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6-(METHYLAMINO)PURINE Suppliers

Americas 1 China 81 Europe 2 Germany 1 India 4 Japan 1 Russia 1 Switzerland 1 Ukraine 1 United Kingdom 4 United States 11 Global 108

Shanghai Hanhong Scientific Co.,Ltd.

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Shanghai Sunway Pharmaceutical Technology Co., Ltd

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Email: mlcheng@sunwaypharm.cn
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Spectrum Chemical Manufacturing Corp.

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Hangzhou Sage Chemical Co., Ltd.

Tel: +86057186818502 13588463833
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TOKYO CHEMICAL INDUSTRY CO., LTD.

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TCI Europe

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Country: Europe
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TCI AMERICA

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Bide Pharmatech Ltd.

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Shanghai YuanYe Biotechnology Co., Ltd.

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WG reagent

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View Lastest Price from 6-(METHYLAMINO)PURINE manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 6-(METHYLAMINO)PURINE 443-72-1
Price: US $1.00-100.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 300KG
Release date: 2024-07-26

Honest Joy Holdings Limited

Product: 6-(Methylamino)purine 443-72-1
Price: US $0.00/KG
Min. Order: 1KG
Purity: 97.9%
Supply Ability: 100 tons
Release date: 2022-02-21

Career Henan Chemical Co

Product: 6-(METHYLAMINO)PURINE 443-72-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1000KG
Release date: 2019-09-04

443-72-1, 6-(METHYLAMINO)PURINERelated Search:

DMT-dA(bz) Phosphoramidite 6-Benzylaminopurine N6-ISOPENTENYLADENOSINE-D6 Bucladesine sodium TRANS-ZEATIN RIBOSIDE N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine PUROMYCIN DIHYDROCHLORIDE 6-Dimethylaminopurine N6-Benzoyl-2'-deoxyadenosine N6-CYCLOHEXYLADENOSINE N6-BENZYLADENOSINE N6,N6-DIMETHYLADENOSINE 6-(METHYLAMINO)PURINE RIBOSIDE N6-CYCLOPENTYLADENOSINE 6-DODECYLADENINE 6-METHYLAMINOPURINE 9-RIBOFURANOSIDE 6-PIPERIDINOPURINE 2-CHLORO-6(METHYLAMINO)PURINE

N-METHYLADENINE

N6-METHYLADENINE

6-Methyladenine

6-Monomethylaminopurine

Adenine, N-methyl-

N(Sup6)-Methyladenine

N(Sup6)-Monomethyladenine

N6-Monomethyladenine

6-(METHYLAMINO)PURINE

N-Methyl-9H-purin-6-amine

methyl(purin-6-yl)amine

N6-Methylademine

1H-Purin-6-amine, N-methyl- (9CI)

N-methyl-7H-purin-6-amine

6-(METHYLAMINO)PURINE 99+%

6-(Methylamino)purine, N-Methyladenine

6-Methylamino-7H-purine

N-Methyl-1H-purin-6-amine

Methyl-(7H-purin-6-yl)-amine

9H-Purin-6-aMine, N-Methyl-

1H-Purin-6-amine, N-methyl-

N6 Methyladenine,N6Methyladenine

443-72-1

Heterocyclic Building Blocks

Purines

Building Blocks

PYRIMIDINE

Pyridines, Pyrimidines, Purines and Pteredines