ChemicalBook > CAS DataBase List > 6-(METHYLAMINO)PURINE

6-(METHYLAMINO)PURINE

Product Name
6-(METHYLAMINO)PURINE
CAS No.
443-72-1
Chemical Name
6-(METHYLAMINO)PURINE
Synonyms
N6-METHYLADENINE;N-Methyl-9H-purin-6-amine;6-Methyladenine;N-methyl-7H-purin-6-amine;N-METHYLADENINE;N6-Methylademine;Adenine, N-methyl-;N6-Monomethyladenine;N(Sup6)-Methyladenine;6-(METHYLAMINO)PURINE
CBNumber
CB1165746
Molecular Formula
C6H7N5
Formula Weight
149.15
MOL File
443-72-1.mol
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6-(METHYLAMINO)PURINE Property

Melting point:
≥300 °C
Boiling point:
256.3±50.0 °C(Predicted)
Density 
1.57±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
DMSO (Slightly, Heated), Methanol (Slightly, Heated)
form 
Solid
pka
9.61±0.20(Predicted)
color 
White to Light Grey
CAS DataBase Reference
443-72-1
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Safety

WGK Germany 
3
F 
10-23
HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TCI Chemical
Product number
M3166
Product name
N-Methyl-7H-purin-6-amine
Packaging
1G
Price
$148
Updated
2025/07/31
Cayman Chemical
Product number
18153
Product name
N6-Methyladenine
Purity
≥98%
Packaging
50mg
Price
$49
Updated
2024/03/01
Cayman Chemical
Product number
18153
Product name
N6-Methyladenine
Purity
≥98%
Packaging
100mg
Price
$87
Updated
2024/03/01
Cayman Chemical
Product number
18153
Product name
N6-Methyladenine
Purity
≥98%
Packaging
250mg
Price
$190
Updated
2024/03/01
Cayman Chemical
Product number
18153
Product name
N6-Methyladenine
Purity
≥98%
Packaging
500mg
Price
$286
Updated
2024/03/01
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6-(METHYLAMINO)PURINE Chemical Properties,Usage,Production

Uses

N6-Methyladenine is a modified purine that is commonly found in genomes of prokaryotes, protists, and plants. It is less common in higher eukaryotes and extremely rare in mammals. Like methylation of other DNA residues, N6-methyladenine represents an epigenetic modification that can affect diverse DNA functions, including replication, repair, and expression.

Uses

6-(Methylamino)purine, 6-methylade is a reagent for substitution of adenine nucleotide analogs containing bicyclohexane ring system locked in northern conformation enhanced potency as py receptor antagonists. Adenine methylation as an epigenic mark has been observed in single-celled organisms and also rarely in mamalian cells.

Definition

ChEBI: A 6-alkylaminopurine that is 9H-purin-6-amine substituted by a methyl group at the amino nitrogen.

Synthesis

87-42-3

74-89-5

443-72-1

Example 147 Steps for the synthesis of 1-[4-(6-(methylamino)purin-9-yl)phenyl]-3-[3-(4-methylpiperazin-1-ylmethyl)-5-(trifluoromethyl)phenyl]urea (Table 2, compound 25): Step A Preparation of 6-methylaminopurine Dissolve 12.5 g (79 mmol) of 6-chloropurine in 20 mL of 40% methanol solution of methylamine and 20 mL of ethanol. The reaction solution was sealed in a reaction tube and stirred at 120 °C for 4 hours. After completion of the reaction, the reaction solution was concentrated, ground with water, filtered to collect the solid, washed with water and dried under vacuum to give 10.78 g (90% yield) of 6-methylaminopurine as a white solid. 1H-NMR (270 MHz, DMSO-d6) δ (ppm): 2.98 (3H, br.s), 7.58 (1H, br.s), 8.06 (1H, s), 8.19 (1H, br.s), 12.89 (1H, br.s). ESI (LC-MS positive mode) m/z 150 (M + H).

IC 50

Human Endogenous Metabolite

Purification Methods

The purine is best purified by recrystallising 2g from 50mL of H2O and 1.2g of charcoal. [UV: Albert & Brown J Chem Soc 2060 1954; UV: Mason J Chem Soc 2071 1954; see also Elion et al. J Am Chem Soc 74 411 1952.] The picrate has m 265o(257o) [Bredereck et al. Chem Ber 81 307 1948]. [Beilstein 26 III/IV 3565.]

References

[1] Patent: EP1724258, 2006, A1. Location in patent: Page/Page column 138

6-(METHYLAMINO)PURINE Preparation Products And Raw materials

Raw materials

Preparation Products

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6-(METHYLAMINO)PURINE Suppliers

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View Lastest Price from 6-(METHYLAMINO)PURINE manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
6-(METHYLAMINO)PURINE 443-72-1
Price
US $1.00-100.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
300KG
Release date
2024-07-26
Honest Joy Holdings Limited
Product
6-(Methylamino)purine 443-72-1
Price
US $0.00/KG
Min. Order
1KG
Purity
97.9%
Supply Ability
100 tons
Release date
2022-02-21
Career Henan Chemical Co
Product
6-(METHYLAMINO)PURINE 443-72-1
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1000KG
Release date
2019-09-04

443-72-1, 6-(METHYLAMINO)PURINERelated Search:

DMT-dA(bz) Phosphoramidite 6-Benzylaminopurine N6-ISOPENTENYLADENOSINE-D6 Bucladesine sodium TRANS-ZEATIN RIBOSIDE N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine PUROMYCIN DIHYDROCHLORIDE 6-Dimethylaminopurine N6-Benzoyl-2'-deoxyadenosine N6-CYCLOHEXYLADENOSINE N6-BENZYLADENOSINE N6,N6-DIMETHYLADENOSINE 6-(METHYLAMINO)PURINE RIBOSIDE N6-CYCLOPENTYLADENOSINE 6-DODECYLADENINE 6-METHYLAMINOPURINE 9-RIBOFURANOSIDE 6-PIPERIDINOPURINE 2-CHLORO-6(METHYLAMINO)PURINE

  • N-METHYLADENINE
  • N6-METHYLADENINE
  • 6-Methyladenine
  • 6-Monomethylaminopurine
  • Adenine, N-methyl-
  • N(Sup6)-Methyladenine
  • N(Sup6)-Monomethyladenine
  • N6-Monomethyladenine
  • 6-(METHYLAMINO)PURINE
  • N-Methyl-9H-purin-6-amine
  • methyl(purin-6-yl)amine
  • N6-Methylademine
  • 1H-Purin-6-amine, N-methyl- (9CI)
  • N-methyl-7H-purin-6-amine
  • 6-(METHYLAMINO)PURINE 99+%
  • 6-(Methylamino)purine, N-Methyladenine
  • 6-Methylamino-7H-purine
  • N-Methyl-1H-purin-6-amine
  • Methyl-(7H-purin-6-yl)-amine
  • 9H-Purin-6-aMine, N-Methyl-
  • 1H-Purin-6-amine, N-methyl-
  • N6 Methyladenine,N6Methyladenine
  • 443-72-1
  • Heterocyclic Building Blocks
  • Purines
  • Building Blocks
  • PYRIMIDINE
  • Pyridines, Pyrimidines, Purines and Pteredines