2-Fluoro-4-(trifluoromethyl)aniline

Product Name: 2-Fluoro-4-(trifluoromethyl)aniline
CAS No.: 69409-98-9
Chemical Name: 2-Fluoro-4-(trifluoromethyl)aniline
Synonyms: 2-Fluoro-4-(trifluor;4-aMino-3-flurorbenzotrifluoride;4-AMINO-3-FLUOROBENZOTRIFLUORIDE;Aminofluorobenzotrifluoride 43---;2-fluoro-4-（trifluoromethyl）anline;2-FLUORO-4-(TRIFLUOROMETHYL)ANILINE;2-Fluoro-4-trifluoromethyl-phenylamine;BenzenaMine, 2-fluoro-4-(trifluoroMethyl)-;2-Fluoro-4-(trifluoromethyl)aniline, alpha,alpha,alpha,2-Tetrafluoro-p-toluidine
CBNumber: CB4475196
Molecular Formula: C7H5F4N
Formula Weight: 179.11
MOL File: 69409-98-9.mol

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2-Fluoro-4-(trifluoromethyl)aniline Property

Boiling point:: 55 °C(Press: 0.3 Torr)
Density: 1.383±0.06 g/cm3(Predicted)
refractive index: 1.4650
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
form: liquid
pka: 1.37±0.10(Predicted)
color: Clear, faint yellow
CAS DataBase Reference: 69409-98-9(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 20/21/22-36/37/38
Safety Statements: 26-36/37/39
RIDADR: 2810
Hazard Note: Irritant
HazardClass: 6.1
PackingGroup: Ⅲ
HS Code: 2921420090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H227Combustible liquid

H302Harmful if swallowed

H311Toxic in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P309IF exposed or if you feel unwell:

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: CDS003152
Product name: 2-Fluoro-4-(trifluoromethyl)aniline
Purity: Aldrich<SUP>CPR</SUP>
Packaging: 1 g
Price: $73.1
Updated: 2025/07/31

TRC

Product number: B435265
Product name: 2-Fluoro-4-(trifluoromethyl)aniline
Packaging: 50mg
Price: $45
Updated: 2021/12/16

TRC

Product number: B435265
Product name: 2-Fluoro-4-(trifluoromethyl)aniline
Packaging: 100mg
Price: $60
Updated: 2021/12/16

Oakwood

Product number: 005809
Product name: 2-Fluoro-4-(trifluoromethyl)aniline
Purity: 99%
Packaging: 250mg
Price: $19
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3830-3-51
Product name: 4-Amino-3-fluorobenzotrifluoride
Packaging: 5G
Price: $32
Updated: 2021/12/16

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2-Fluoro-4-(trifluoromethyl)aniline Chemical Properties,Usage,Production

Synthesis

115029-24-8

69409-98-9

General procedure for the synthesis of 4-amino-3-fluorobenzotrifluoride from 2-fluoro-4-(trifluoromethyl)benzoic acid: 2-fluoro-4-(trifluoromethyl)benzoic acid (1 kg, 4.805 mol, 1.00 eq.) and CuCl (14.26 g, 0.144 mol, 0.03 eq.) were dissolved in 0-BuOH (11.7 L). Triethylamine (TEA, 533.8 g, 5.286 mol, 1.10 eq.) was added slowly and dropwise at room temperature. The reaction mixture was then heated to 50 °C and diphenylphosphoryl azide (DPPA, 1393 g, 5.045 mol, 1.05 eq.) was added slowly dropwise at 50-60 °C. The reaction mixture was heated at 80-85 °C overnight. After completion of the reaction, the solution was concentrated under reduced pressure. The residue was dissolved in water and filtered. The filtrate was extracted with ethyl acetate and the organic layer was dried with anhydrous Na2SO4, filtered and concentrated under reduced pressure. The residue was dissolved in tert-butyl methyl ether (TBME) and HCl gas was passed into it for 2 hours. The filtrate was collected, dissolved in water and alkalized with 2M NaOH solution. The alkalized solution was extracted with TBME and the organic layer was dried and concentrated under reduced pressure to give 2-fluoro-4-(trifluoromethyl)aniline (498 g, 58% yield) as a red oil. The product was confirmed by 1H-NMR (300 MHz, CDCl3): δ 7.27 (m, 2H), 6.82 (m, 1H), 4.05 (bs, 2H); mass spectrum (MS): m/z = 180 [M + H]+.

References

[1] Patent: US2013/281710, 2013, A1. Location in patent: Paragraph 0268; 269; 270

2-Fluoro-4-(trifluoromethyl)aniline Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Fluoro-4-(trifluoromethyl)aniline Suppliers

China 115 Europe 2 France 1 Germany 4 India 2 Italy 1 The Netherlands 1 United Kingdom 12 United States 24 Global 162

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View Lastest Price from 2-Fluoro-4-(trifluoromethyl)aniline manufacturers

Career Henan Chemical Co

Product: 2-Fluoro-4-(trifluoromethyl)aniline 69409-98-9
Price: US $1.00/KG
Min. Order: 100g
Purity: 98%
Supply Ability: 200KG
Release date: 2019-12-17

69409-98-9, 2-Fluoro-4-(trifluoromethyl)anilineRelated Search:

2-FLUORO-4-(TRIFLUOROMETHYL)ANILINE

4-AMINO-3-FLUOROBENZOTRIFLUORIDE

2-fluoro-4-（trifluoromethyl）anline

Aminofluorobenzotrifluoride 43---

2-Fluoro-4-(trifluor

BenzenaMine, 2-fluoro-4-(trifluoroMethyl)-

4-aMino-3-flurorbenzotrifluoride

2-Fluoro-4-(trifluoromethyl)aniline, alpha,alpha,alpha,2-Tetrafluoro-p-toluidine

2-Fluoro-4-trifluoromethyl-phenylamine

69409-98-9

69409-98-8

Benzenes

Aromatic Halides (substituted)