ChemicalBook > CAS DataBase List > 4-(1H-PYRROL-1-YL)ANILINE

4-(1H-PYRROL-1-YL)ANILINE

Product Name
4-(1H-PYRROL-1-YL)ANILINE
CAS No.
52768-17-9
Chemical Name
4-(1H-PYRROL-1-YL)ANILINE
Synonyms
ASISCHEM A93505;BUTTPARK 98\12-84;4-Pyrrol-1-yl-aniline;4-(1-Pyrrolyl)aniline;1-(4-AMINOPHENYL)PYRROLE;4-(1H-PYRROL-1-YL)ANILINE;4-Pyrrol-1-yl-phenylamine;Benzenamine, 4-(1H-pyrrol-1-yl)-
CBNumber
CB4476638
Molecular Formula
C10H10N2
Formula Weight
158.2
MOL File
52768-17-9.mol
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4-(1H-PYRROL-1-YL)ANILINE Property

Melting point:
81 °C
Boiling point:
307.8±25.0 °C(Predicted)
Density 
1.09±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
pka
3.36±0.10(Predicted)
Appearance
Off-white to light yellow Solid
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36/37/39
HazardClass 
IRRITANT
HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
P998810
Product name
4-(1H-Pyrrol-1-yl)aniline
Packaging
10mg
Price
$45
Updated
2021/12/16
Apolloscientific
Product number
OR29302
Product name
4-(1H-Pyrrol-1-yl)aniline
Packaging
500mg
Price
$25
Updated
2021/12/16
SynQuest Laboratories
Product number
3H30-1-F6
Product name
4-(1H-Pyrrol-1-yl)aniline
Packaging
500mg
Price
$28
Updated
2021/12/16
Apolloscientific
Product number
OR29302
Product name
4-(1H-Pyrrol-1-yl)aniline
Packaging
1g
Price
$35
Updated
2021/12/16
SynQuest Laboratories
Product number
3H30-1-F6
Product name
4-(1H-Pyrrol-1-yl)aniline
Packaging
1g
Price
$39
Updated
2021/12/16
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4-(1H-PYRROL-1-YL)ANILINE Chemical Properties,Usage,Production

Synthesis

4533-42-0

52768-17-9

Under standard reaction conditions, 5.0 mg of Pd-gCN catalyst (containing 5.0 wt% Pd) was added to an ethanol solution (2 mL) containing 1.0 mM 1-(4-nitrophenyl)-1H-pyrrole, followed by the addition of 2 mM (1.2 eq., 0.07 mL) of 60% hydrazine hydrate solution. The reaction mixture was transferred to a 10 mL round bottom flask and reacted at reflux temperature (70 °C) for 4 hours. After completion of the reaction, the mixture was cooled to room temperature and the catalyst was isolated by filtration. The filtrate was purified by silica gel column chromatography to give 4-(1-pyrrolyl)aniline. For dinitroaromatic substrates, 4.0 mM (2.4 eq., 0.14 mL) of 60% hydrazine hydrate solution is required.

References

[1] Applied Catalysis A: General, 2016, vol. 523, p. 31 - 38
[2] European Journal of Medicinal Chemistry, 2015, vol. 96, p. 369 - 380
[3] Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 1996, vol. 51, # 6, p. 757 - 764
[4] Recueil des Travaux Chimiques des Pays-Bas, 1943, vol. 62, p. 177,181, 183
[5] Farmaco, Edizione Scientifica, 1983, vol. 38, # 4, p. 219 - 231

4-(1H-PYRROL-1-YL)ANILINE Preparation Products And Raw materials

Raw materials

Preparation Products

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