4-(1H-PYRROL-1-YL)ANILINE

4-(1H-PYRROL-1-YL)ANILINE Property

Melting point:

81 °C

Boiling point:

307.8±25.0 °C(Predicted)

Density 

1.09±0.1 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

pka

3.36±0.10(Predicted)

Appearance

Off-white to light yellow Solid

Safety

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36/37/39

HazardClass 

IRRITANT

HS Code 

2933998090

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

4-(1H-PYRROL-1-YL)ANILINE Chemical Properties,Usage,Production

Synthesis

Under standard reaction conditions, 5.0 mg of Pd-gCN catalyst (containing 5.0 wt% Pd) was added to an ethanol solution (2 mL) containing 1.0 mM 1-(4-nitrophenyl)-1H-pyrrole, followed by the addition of 2 mM (1.2 eq., 0.07 mL) of 60% hydrazine hydrate solution. The reaction mixture was transferred to a 10 mL round bottom flask and reacted at reflux temperature (70 °C) for 4 hours. After completion of the reaction, the mixture was cooled to room temperature and the catalyst was isolated by filtration. The filtrate was purified by silica gel column chromatography to give 4-(1-pyrrolyl)aniline. For dinitroaromatic substrates, 4.0 mM (2.4 eq., 0.14 mL) of 60% hydrazine hydrate solution is required.

References

[1] Applied Catalysis A: General, 2016, vol. 523, p. 31 - 38
[2] European Journal of Medicinal Chemistry, 2015, vol. 96, p. 369 - 380
[3] Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 1996, vol. 51, # 6, p. 757 - 764
[4] Recueil des Travaux Chimiques des Pays-Bas, 1943, vol. 62, p. 177,181, 183
[5] Farmaco, Edizione Scientifica, 1983, vol. 38, # 4, p. 219 - 231