MKC8866

Product Name: MKC8866
CAS No.: 1338934-59-0
Chemical Name: MKC8866
Synonyms: 181697;MKC8866;MKC8866;MKC-8866;IRE-1α inhibitor 1;MKC8866, 10 mM in DMSO;IRE1 RNase inhibitor 8866;IRE1 RNase inhibitor 8866 (MKC8866;Inositol requiring enzyme 1,inhibit,MKC-8866,IRE1,MKC8866,Inhibitor,MKC 8866;7-hydroxy-6-methoxy-4-methyl-3-(2-morpholino-2-oxoethyl)-2-oxo-2H-chromene-8-carbaldehyde;2H-1-Benzopyran-8-carboxaldehyde, 7-hydroxy-6-methoxy-4-methyl-3-[2-(4-morpholinyl)-2-oxoethyl]-2-oxo-
CBNumber: CB44796671
Molecular Formula: C18H19NO7
Formula Weight: 361.35
MOL File: 1338934-59-0.mol

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MKC8866 Property

Boiling point:: 620.0±55.0 °C(Predicted)
Density: 1.373±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:16.67(Max Conc. mg/mL);46.13(Max Conc. mM)
form: A solid
pka: 6.20±0.20(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Axon Medchem

Product number: Axon3223
Product name: MKC8866
Purity: 99%
Packaging: 5mg
Price: $115.5
Updated: 2021/12/16

Axon Medchem

Product number: Axon3223
Product name: MKC8866
Purity: 99%
Packaging: 25mg
Price: $401.5
Updated: 2021/12/16

ChemScene

Product number: CS-0026810
Product name: MKC8866
Purity: 99.87%
Packaging: 5mg
Price: $550
Updated: 2021/12/16

Axon Medchem

Product number: Axon3223
Product name: MKC8866
Purity: 99%
Packaging: 2x25mg
Price: $616
Updated: 2021/12/16

ChemScene

Product number: CS-0026810
Product name: MKC8866
Purity: 99.87%
Packaging: 10mg
Price: $850
Updated: 2021/12/16

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MKC8866 Chemical Properties,Usage,Production

Uses

MKC8866, a salicylaldehyde analog, is a potent, selective IRE1 RNase inhibitor with an IC50 of 0.29 μM in human vitro. MKC8866 strongly inhibits Dithiothreitol-induced X-box-binding protein 1-spliced (XBP1s) expression with an EC50 of 0.52 μM and unstresses RPMI 8226 cells with an IC50 of 0.14 μM[1]. MKC8866 inhibits IRE1 RNase in breast cancer cells leading to the decreased production of pro-tumorigenic factors and it can inhibits prostate cancer (PCa) tumor growth[2].

Biological Activity

MKC8866 (IRE1-IN-8866) is a salicylaldehyde analog, a specific IRE1α RNase inhibitor with IC50 of 0.29 μM against human IRE1α in vitro.

in vivo

MKC8866 (oral ; 300 mg/kg; for 28 days) reduces tumor regrowth post-NSC 125973 withdrawal^[1].

Animal Model:	Female athymic nude mice with MDA-MB-231 tumor^[1]
Dosage:	300 mg/kg
Administration:	Oral; for 28 days
Result:	Reduced tumor regrowth post-NSC 125973 withdrawal.

target

Target	Value
hIRE1α (Cell-free assay)	0.29 μM

References

[1] Sheng X, et al. IRE1α-XBP1s pathway promotes prostate cancer by activating c-MYC signaling. Nat Commun. 2019 Jan 24;10(1):323. DOI:10.1038/s41467-018-08152-3
[2] Logue SE, et al. Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy. Nat Commun. 2018 Aug 15;9(1):3267. DOI:10.1038/s41467-018-05763-8

MKC8866 Preparation Products And Raw materials

Raw materials

Preparation Products

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MKC8866 Suppliers

China 55 United States 3 Global 58

ChemShuttle, Inc.

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Shanghai Chaolan Chemical Technology Center

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Heze Development Zone chuangli Chemical Co., Ltd.

Tel: 0530-+86-530-529 6766，+86-15666160102 15666160102
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TargetMol Chemicals Inc.

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1338934-59-0, MKC8866Related Search:

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MKC8866

2H-1-Benzopyran-8-carboxaldehyde, 7-hydroxy-6-methoxy-4-methyl-3-[2-(4-morpholinyl)-2-oxoethyl]-2-oxo-

IRE1 RNase inhibitor 8866 (MKC8866

7-hydroxy-6-methoxy-4-methyl-3-(2-morpholino-2-oxoethyl)-2-oxo-2H-chromene-8-carbaldehyde

MKC8866;MKC-8866

181697

IRE1 RNase inhibitor 8866

Inositol requiring enzyme 1,inhibit,MKC-8866,IRE1,MKC8866,Inhibitor,MKC 8866

IRE-1α inhibitor 1

MKC8866, 10 mM in DMSO

1338934-59-0