MKC3946
- Product Name
- MKC3946
- CAS No.
- 1093119-54-0
- Chemical Name
- MKC3946
- Synonyms
- MKC3946;MKC-3946 ，S8286;MKC3946, 10 mM in DMSO;IRE1α Inhibitor, MKC-3946;MKC3946;MKC-3946;MKC 3946;Inositol requiring enzyme 1,inhibit,IRE1,MKC3946,Inhibitor,MKC 3946,MKC-3946;2-Hydroxy-6-(5-(4-methylpiperazine-1-carbonyl)thiophen-2-yl)-1-naphthaldehyde;1-Naphthalenecarboxaldehyde, 2-hydroxy-6-[5-[(4-methyl-1-piperazinyl)carbonyl]-2-thienyl]-
- CBNumber
- CB03155064
- Molecular Formula
- C21H20N2O3S
- Formula Weight
- 380.46
- MOL File
- 1093119-54-0.mol
MKC3946 Property
- Boiling point:
- 591.6±50.0 °C(Predicted)
- Density
- 1.337±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- solubility
- DMSO:20.0(Max Conc. mg/mL);52.57(Max Conc. mM)
- form
- A crystalline solid
- pka
- 8.18±0.50(Predicted)
- color
- White to yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 5.32758
- Product name
- IRE1α Inhibitor, MKC-3946
- Packaging
- 10 mg
- Price
- $172
- Updated
- 2025/07/31
- Product number
- 19152
- Product name
- MKC-3946
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $56
- Updated
- 2024/03/01
- Product number
- 19152
- Product name
- MKC-3946
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $241
- Updated
- 2024/03/01
- Product number
- 19152
- Product name
- MKC-3946
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $429
- Updated
- 2024/03/01
- Product number
- 19152
- Product name
- MKC-3946
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $936
- Updated
- 2024/03/01
MKC3946 Chemical Properties,Usage,Production
Uses
MKC3946 is a potent IRE1α inhibitor, used for cancer research.
Biological Activity
MKC3946 is a soluble inhibitor of the IRE1α endoribonuclease domain, causing moderate growth inhibition in multiple myeloma cell lines without toxic effects on normal monocytes.
in vivo
In an in vivo model of endoplasmic reticulum stress, MKC-3946 inhibits cleavage of XBP1 and significantly inhibits myeloma cell growth.
target
| Target | Value |
| IRE1α endoribonuclease () |