MK8745
- Product Name
- MK8745
- CAS No.
- 885325-71-3
- Chemical Name
- MK8745
- Synonyms
- MK8745;CS-1904;MK8745 USP/EP/BP;Inhibitor,inhibit,MK8745,Aurora Kinase,MK-8745,MK 8745,Apoptosis;6-[[4-(3-Chloro-2-fluorobenzoyl)piperazin-1-yl]methyl]-N-(thiazol-2-yl)pyridin-2-amine;(3-Chloro-2-fluorophenyl)(4-((6-(thiazol-2-ylamino)pyridin-2-yl)methyl)piperazin-1-yl)methanon;Methanone, (3-chloro-2-fluorophenyl)[4-[[6-(2-thiazolylamino)-2-pyridinyl]methyl]-1-piperazinyl]-;(3-chloro-2-fluorophenyl)(4-((6-(thiazol-2-ylamino)pyridin-2-yl)methyl)piperazin-1-yl)methanone. MK-8745
- CBNumber
- CB52668038
- Molecular Formula
- C20H19ClFN5OS
- Formula Weight
- 431.91
- MOL File
- 885325-71-3.mol
MK8745 Property
- Melting point:
- 177-179°C
- Boiling point:
- 605.5±65.0 °C(Predicted)
- Density
- 1.430±0.06 g/cm3(Predicted)
- storage temp.
- Refrigerator
- solubility
- DMSO (Slightly), Methanol (Slightly, Heated)
- form
- Solid
- pka
- 5.20±0.10(Predicted)
- color
- Off-White
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 26190
- Product name
- MK-8745
- Packaging
- 10mg
- Price
- $87
- Updated
- 2024/03/01
- Product number
- 26190
- Product name
- MK-8745
- Packaging
- 50mg
- Price
- $286
- Updated
- 2024/03/01
- Product number
- 26190
- Product name
- MK-8745
- Packaging
- 5mg
- Price
- $49
- Updated
- 2024/03/01
- Product number
- 26190
- Product name
- MK-8745
- Packaging
- 25mg
- Price
- $190
- Updated
- 2024/03/01
- Product number
- M425040
- Product name
- MK-8745
- Packaging
- 50mg
- Price
- $250
- Updated
- 2021/12/16
MK8745 Chemical Properties,Usage,Production
Uses
MK-8745 is a potent and selective Aurora A kinase inhibitor that induces apoptotic cell death in a p53-dependent manner when tested in vitro in cell lines of multiple lineages.
Biological Activity
mk-8745 is a novel and selective inhibitor of aurora a with ic50 value of 0.6 nm [1].aurora a kinase is a member of mitotic serine/threonine kinases and plays an important role in cellular division by controlling chromatid segregation. it has been reported that abnormal expression of aurora a is correlated with the high occurrence of cancer and its expression determines cell sensitivity to mk-8745 treatment [1].mk-8745 is a potent aurora a inhibitor. when tested with p53-/+ cell lines, mk-8745 treatment induced apoptotic cell death in a p53-dependent manner through inhibiting aurora a activity [1]. in non-hodgkin lymphoma (nhl) cell lines, mk-8745 treatment arrested cell cycle in g2/m phase and induced cell death via inhibiting aurora a kinase [2]. in hct 116 puma (-), hct116 p21 (-), hct116 bax(-) and hct116 chk2(-) cell lines, mk-8745 treatment induced cell apoptosis with the percent of 25%, 22%, 25%, and 22%, respectively [3].in female athymic nude mice model subcutaneous xenografted with hct116 puma (-), hct116 p21 (-), hct116 bax(-) and hct116 chk2(-) cells, administration of mk-8745 significantly inhibited tumor growth [3].
target
Aurora A
References
[1]. nair, j.s., a.l. ho, and g.k. schwartz, the induction of polyploidy or apoptosis by the aurora a kinase inhibitor mk8745 is p53-dependent. cell cycle, 2012. 11(4): p. 807-17.
[2]. chowdhury, a., s. chowdhury, and m.y. tsai, a novel aurora kinase a inhibitor mk-8745 predicts tpx2 as a therapeutic biomarker in non-hodgkin lymphoma cell lines. leuk lymphoma, 2012. 53(3): p. 462-71.
[3]. shionome, y., et al., integrity of p53 associated pathways determines induction of apoptosis of tumor cells resistant to aurora-a kinase inhibitors. plos one, 2013. 8(1): p. e55457.
MK8745 Preparation Products And Raw materials
Raw materials
Preparation Products
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