MK8745

ChemicalBook > CAS DataBase List > MK8745

Product Name: MK8745
CAS No.: 885325-71-3
Chemical Name: MK8745
Synonyms: MK8745;CS-1904;MK8745 USP/EP/BP;Inhibitor,inhibit,MK8745,Aurora Kinase,MK-8745,MK 8745,Apoptosis;6-[[4-(3-Chloro-2-fluorobenzoyl)piperazin-1-yl]methyl]-N-(thiazol-2-yl)pyridin-2-amine;(3-Chloro-2-fluorophenyl)(4-((6-(thiazol-2-ylamino)pyridin-2-yl)methyl)piperazin-1-yl)methanon;Methanone, (3-chloro-2-fluorophenyl)[4-[[6-(2-thiazolylamino)-2-pyridinyl]methyl]-1-piperazinyl]-;(3-chloro-2-fluorophenyl)(4-((6-(thiazol-2-ylamino)pyridin-2-yl)methyl)piperazin-1-yl)methanone. MK-8745
CBNumber: CB52668038
Molecular Formula: C20H19ClFN5OS
Formula Weight: 431.91
MOL File: 885325-71-3.mol

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MK8745 Property

Melting point:: 177-179°C
Boiling point:: 605.5±65.0 °C(Predicted)
Density: 1.430±0.06 g/cm3(Predicted)
storage temp.: Refrigerator
solubility: DMSO (Slightly), Methanol (Slightly, Heated)
form: Solid
pka: 5.20±0.10(Predicted)
color: Off-White

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 26190
Product name: MK-8745
Packaging: 10mg
Price: $87
Updated: 2024/03/01

Cayman Chemical

Product number: 26190
Product name: MK-8745
Packaging: 50mg
Price: $286
Updated: 2024/03/01

Cayman Chemical

Product number: 26190
Product name: MK-8745
Packaging: 5mg
Price: $49
Updated: 2024/03/01

Cayman Chemical

Product number: 26190
Product name: MK-8745
Packaging: 25mg
Price: $190
Updated: 2024/03/01

TRC

Product number: M425040
Product name: MK-8745
Packaging: 50mg
Price: $250
Updated: 2021/12/16

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MK8745 Chemical Properties,Usage,Production

Uses

MK-8745 is a potent and selective Aurora A kinase inhibitor that induces apoptotic cell death in a p53-dependent manner when tested in vitro in cell lines of multiple lineages.

Biological Activity

mk-8745 is a novel and selective inhibitor of aurora a with ic50 value of 0.6 nm [1].aurora a kinase is a member of mitotic serine/threonine kinases and plays an important role in cellular division by controlling chromatid segregation. it has been reported that abnormal expression of aurora a is correlated with the high occurrence of cancer and its expression determines cell sensitivity to mk-8745 treatment [1].mk-8745 is a potent aurora a inhibitor. when tested with p53-/+ cell lines, mk-8745 treatment induced apoptotic cell death in a p53-dependent manner through inhibiting aurora a activity [1]. in non-hodgkin lymphoma (nhl) cell lines, mk-8745 treatment arrested cell cycle in g2/m phase and induced cell death via inhibiting aurora a kinase [2]. in hct 116 puma (-), hct116 p21 (-), hct116 bax(-) and hct116 chk2(-) cell lines, mk-8745 treatment induced cell apoptosis with the percent of 25%, 22%, 25%, and 22%, respectively [3].in female athymic nude mice model subcutaneous xenografted with hct116 puma (-), hct116 p21 (-), hct116 bax(-) and hct116 chk2(-) cells, administration of mk-8745 significantly inhibited tumor growth [3].

target

Aurora A

References

[1]. nair, j.s., a.l. ho, and g.k. schwartz, the induction of polyploidy or apoptosis by the aurora a kinase inhibitor mk8745 is p53-dependent. cell cycle, 2012. 11(4): p. 807-17.
[2]. chowdhury, a., s. chowdhury, and m.y. tsai, a novel aurora kinase a inhibitor mk-8745 predicts tpx2 as a therapeutic biomarker in non-hodgkin lymphoma cell lines. leuk lymphoma, 2012. 53(3): p. 462-71.
[3]. shionome, y., et al., integrity of p53 associated pathways determines induction of apoptosis of tumor cells resistant to aurora-a kinase inhibitors. plos one, 2013. 8(1): p. e55457.

MK8745 Preparation Products And Raw materials

Raw materials

Preparation Products

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885325-71-3, MK8745Related Search:

MK-8998 MK-4101 MK-3903 mk-1064 (S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxaMide MK 0557 MK-0812 (Succinate) MKC9989 MKC3946 MK-5108 (VX-689) Aurora A Inhibitor I VE 822 LDN-193189 Hesperadin MLN8054

MK8745

6-[[4-(3-Chloro-2-fluorobenzoyl)piperazin-1-yl]methyl]-N-(thiazol-2-yl)pyridin-2-amine

Methanone, (3-chloro-2-fluorophenyl)[4-[[6-(2-thiazolylamino)-2-pyridinyl]methyl]-1-piperazinyl]-

(3-chloro-2-fluorophenyl)(4-((6-(thiazol-2-ylamino)pyridin-2-yl)methyl)piperazin-1-yl)methanone. MK-8745

(3-Chloro-2-fluorophenyl)(4-((6-(thiazol-2-ylamino)pyridin-2-yl)methyl)piperazin-1-yl)methanon

CS-1904

MK8745 USP/EP/BP

Inhibitor,inhibit,MK8745,Aurora Kinase,MK-8745,MK 8745,Apoptosis

885325-71-3

C20H19ClFN5OS

API

Inhibitors