ChemicalBook > CAS DataBase List > MKC9989

MKC9989

Product Name
MKC9989
CAS No.
1338934-20-5
Chemical Name
MKC9989
Synonyms
MKC9989;Inhibitor,Inositol requiring enzyme 1,MKC-9989,inhibit,MKC9989,IRE1,MKC 9989;7-hydroxy-6-methoxy-3-(2-(2-methoxyethoxy)ethyl)-4-methyl-2-oxo-2H-chromene-8-carbaldehyde;2H-1-Benzopyran-8-carboxaldehyde, 7-hydroxy-6-methoxy-3-[2-(2-methoxyethoxy)ethyl]-4-methyl-2-oxo-
CBNumber
CB03386497
Molecular Formula
C17H20O7
Formula Weight
336.34
MOL File
1338934-20-5.mol
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MKC9989 Property

storage temp. 
Store at -20°C
solubility 
DMSO : ≥ 50 mg/mL (148.66 mM);Water : < 0.1 mg/mL (insoluble)
form 
Solid
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-7770
Product name
MKC9989
Purity
98.36%
Packaging
1mg
Price
$132
Updated
2021/12/16
ChemScene
Product number
CS-7770
Product name
MKC9989
Purity
98.36%
Packaging
5mg
Price
$396
Updated
2021/12/16
ChemScene
Product number
CS-7770
Product name
MKC9989
Purity
98.36%
Packaging
10mg
Price
$600
Updated
2021/12/16
ChemScene
Product number
CS-7770
Product name
MKC9989
Purity
98.36%
Packaging
50mg
Price
$1800
Updated
2021/12/16
ChemScene
Product number
CS-7770
Product name
MKC9989
Purity
98.36%
Packaging
100mg
Price
$2520
Updated
2021/12/16
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MKC9989 Chemical Properties,Usage,Production

Description

MKC9989 is a Hydroxy aryl aldehydes (HAA) inhibitor and also inhibits IRE1α with an IC50 of 0.23 to 44 μM.

At 10 μM concentration, MKC9989 completely inhibits both basal and thapsigargin induced splicing of XBP1 mRNA. These effects are observed even in cells pre-treated with thapsigargin, indicating that MKC9989 can fully reverse the onset of XPB1 splicing after the UPR is initiated. In parallel analysis, MKC9989, significantly stabilizes the RIDD target CD59 mRNA when co-administered with thapsigargin relative to thapsigargin treatment alone and modestly increases levels of CD59 mRNA in non-stressed cells, the latter likely reflects the inhibition of baseline RIDD activity. In contrast to effects on XBP1 splicing, MKC9989 moderately stabilizes CD59 levels when administered 2 hour post treatment with thapsigargin. Finally, the potency of MKC9989 against the splicing of XBP1 mRNA (EC50=0.33 μM) is comparable to its potency against RNA cleavage in vitro[1].

Reactions

From a functional point of the view, the MKC9989 inhibitor belongs to a series of IRE1 RNase inhibitors termed hydroxy aryl aldehydes (HAA) where the aldehyde moiety reacts chemically with the amine side chain of K907 through a Schiff base reaction[2].

References

[1]. Sanches M, et al. Structure and mechanism of action of the hydroxy-aryl-aldehyde class of IRE1 endoribonuclease inhibitors. Nat Commun. 2014 Aug 28;5:4202.
[2] Mahdizadeh S, et al. Deciphering the selectivity of inhibitor MKC9989 towards residue K907 in IRE1α; a multiscale in silico approach. RSC Advances, 2020; 10: 19720-19729.

MKC9989 Preparation Products And Raw materials

Raw materials

Preparation Products

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MKC9989 Suppliers

ChemShuttle, Inc.
Tel
0510-83588313-802 18800520310;
Email
sales@chemshuttle.com
Country
China
ProdList
3002
Advantage
62
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9806
Advantage
58
Twochem Co.Ltd.
Tel
021-58111628 15800915896
Fax
QQ 3285589261
Email
sales@twochem.com
Country
China
ProdList
1788
Advantage
58
Shanghai Gugang New Materials Technology Co. Ltd.
Tel
021-51317962
Fax
021-51317962
Email
296935822@qq.com
Country
China
ProdList
978
Advantage
58
Tianjin Kaifu Pharmaceutical Technology Co., Ltd.
Tel
18081075745
Email
chemflowtech@sina.com
Country
China
ProdList
1886
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58
Shanghai Zeye Biotechnology Co., Ltd.
Tel
021-61998551 13122364865
Email
sale1@shzysw.net
Country
China
ProdList
9772
Advantage
58
Shanghai hongqu biomedical technology co. LTD
Tel
88888888888
Email
hongquchem@qq.com
Country
China
ProdList
5132
Advantage
58
Chunchuang (Wuhan) Technology Co., Ltd
Tel
15342225168
Email
yutianchun2007@126.com
Country
China
ProdList
10003
Advantage
58

1338934-20-5, MKC9989Related Search:


  • MKC9989
  • 7-hydroxy-6-methoxy-3-(2-(2-methoxyethoxy)ethyl)-4-methyl-2-oxo-2H-chromene-8-carbaldehyde
  • 2H-1-Benzopyran-8-carboxaldehyde, 7-hydroxy-6-methoxy-3-[2-(2-methoxyethoxy)ethyl]-4-methyl-2-oxo-
  • Inhibitor,Inositol requiring enzyme 1,MKC-9989,inhibit,MKC9989,IRE1,MKC 9989
  • 1338934-20-5